User:Jungwhan Kim

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Go to [[JHIBRG]]
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====[https://sites.google.com/site/jaykimlaboratory/ '''Go to Jay Kim Lab Website''']====
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====JHIBRG Member====
 
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[[Image:JWKIM.jpg|330px|none]]
 
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[[Image:JW KIM.jpg|150px|none]]
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===Jungwhan Kim, D.V.M., Ph.D.===
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===''Jungwhan (Jay) Kim, D.V.M., Ph.D''.===
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'''Post-Doctoral Fellow''' ([http://www.biology.ucsd.edu/labs/johnson/index.html '''Randall Johnson Lab'''])
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'''Assistant Professor'''
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'''Division of Biological Sciences'''
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'''[http://www.utdallas.edu/biology/ Department of Molecular and Cell Biology]'''
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'''University of California, San Diego (UCSD)'''
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'''[http://www.utdallas.edu The University of Texas at Dallas]'''
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'''9500 Gilman Drive NSB 5325A, La Jolla, CA 92093'''
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'''800 W. Campbell Road, Room FO3.704G'''
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'''Lab Tel) 858-822-5832'''
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'''Richardson TX 75080'''
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'''Email: vetjayk@gmail.com'''
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'''Phone: 972-883-3502'''
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'''Email: jay.kim@utdallas.edu'''
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===Current Research Interests===
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[https://sites.google.com/site/jaykimlaboratory/ '''Jay Kim Lab Website''']
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[[Image:cellcover.gif|frame|250px|right|''Cell Metabolism Cover Mar 2006'']]
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'''The role of stromal HIFs in the development of breast cancer'''
 
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===Academic Positions===
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*'''Assistant Professor (2013 Apr - Present ): Department of Molecular and Cell Biology, University of Texas at Dallas, Texas, USA'''
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===Previous Research Interests===
 
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[[Image:NRCcover.gif|frame|200px|right|''Nature Reviews Cancer Cover Jan 2008'']]
 
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I have been studying the molecular mechanisms underlying oncogenic alterations of cellular metabolism by the c-Myc oncoprotein [http://www.myc-cancer-gene.org (Myc Target Gene Database).] c-Myc heterodimerizes with Max to bind specific DNA sequences (CACGTG), termed E box and transactivates its target genes. Using phylogenetic footprinting and chromatin immunoprecipitation (ChIP) assays, I found that c-Myc overexpression activates genes encoding proteins involved in glycolysis and contributes to the Warburg effect or aerobic glycolysis, which is characteristic of essentially all solid tumors [http://mcb.asm.org/cgi/content/full/24/13/5923?view=long&pmid=15199147 ''(Kim J. et.al. MCB, 2004'').] c-Myc-mediated aerobic glycolysis is further modulated by hypoixc tumor microenvironment. I demonstrated that in cancer, dysregulated c-Myc cooperates with HIF-1 to enhance glycolysis and angiogenesis ([http://mcb.asm.org/cgi/content/full/27/21/7381?view=long&pmid=17785433 ''Kim J. et.al. MCB 2007''.],[http://www.nature.com/nrc/journal/v8/n1/abs/nrc2274.html ''Dang C. et. al. Nature Reviews Cancer 2008''])  I also have been studying metabolic reprogramming of cells in response to hypoxia. I found that hypoxic induction of pyruvate dehydrogenase kinase 1 (PDK1) actively suppresses mitochondrial functions, which results in preserving oxygen consumption and attenuating ROS production under hypoxic conditions [http://www.cellmetabolism.org/content/issue?volume=3&issue=3 (''Kim J. et. al. Cell Metabolism, 2006'').]This metabolic shift confers optimization of efficient respiration of hypoxic cells, which contributes to tumor progression under hypoxic microenvironment. These studies lead to the concept that tumor bioenergetics derived from either cell autonomous oncogenic events or adaptive responses to hypoxic microenvironment could be an attractive target for the cancer therapeutics.
 
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===Education and Professional Training===
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===Education===
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*'''D.V.M. (1995 Mar - 2000 Feb) : [http://veterinary.konkuk.ac.kr Kon-kuk University, School of Veterinary Medicine], Seoul, Korea (Summa cum Laude)'''
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*D.V.M. (1995 Mar -2000 Feb) : [http://www.konkuk.ac.kr/org/index.php?code=college22.htm&sliding=sub1 Kon-kuk University, School of Veterinary Medicine], Seoul, Korea (Summa cum Laude)  
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*Ph.D. (2002 Sep -2006 Feb) : [http://pathology.jhu.edu/department/pathbio.cfm Johns Hopkins, School of Medicine (Pathobiology)], Maryland, USA (Mentor, [http://humangenetics.jhmi.edu/index.php?option=com_content&task=view&id=38&Itemid=51 Chi V. Dang, M.D., Ph.D.])
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===Professional Training===
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*Researcher; 2000 Feb - 2000 Sep ; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea
*Researcher; 2000 Feb - 2000 Sep ; Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea
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*Research Fellow; 2000 - 2002 ; University of Pennsylvania, School of Medicine, Dept. of Pathology & Lab Medicine (Supervisor; [http://mstp.aecom.yu.edu/muschel,_ruth.html Ruth J. Muschel, M.D., Ph.D.])
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*Research Fellow; 2000 - 2002 ; University of Pennsylvania, School of Medicine, Dept. of Pathology & Lab Medicine (Supervisor; [http://www.rob.ox.ac.uk/research/researchgroups/ruth-j-muschel/ Ruth J. Muschel, M.D., Ph.D.])
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*Post-Doctoral Fellow; 2006 - 2007 ; Johns Hopkins University, School of Medicine, Maryland, USA. Dept. of Medicine (Supervisor; [http://humangenetics.jhmi.edu/index.php?option=com_content&task=view&id=38&Itemid=51 Chi V. Dang, M.D., Ph.D.])
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*'''Ph.D. (2002 Sep -2006 Feb) : [http://pathology.jhu.edu/department/pathbio.cfm Johns Hopkins, School of Medicine (Pathobiology)], Maryland, USA (Mentor, [http://www.penncancer.org/chi_dang_md_phd_director Chi V. Dang, M.D., Ph.D.])'''
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*Post-Doctoral Fellow; 2007 - 2008 ; University of California San Francisco, School of Medicine, California, USA
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*Post-Graduate Research; 2006 - 2007 ; Johns Hopkins University, School of Medicine, Maryland, USA. Dept. of Medicine (Supervisor; [http://www.penncancer.org/chi_dang_md_phd_director Chi V. Dang, M.D., Ph.D.])
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*Post-Doctoral Fellow; 2008 - present ; University of California San Diego, Division of Biological Sciences, California, USA (Supervisor; [http://www-biology.ucsd.edu/faculty/johnson.html Randall S. Johnson, Ph.D.])
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*Post-Doctoral Fellow; 2007 - 2008 ; University of California San Francisco, School of Medicine, California, USA (Supervisor; [http://werblab.ucsf.edu Zena Werb, Ph.D.])
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*Post-Doctoral Fellow; 2008 - 2012 ; University of California San Diego, Division of Biological Sciences, California, USA (Supervisor; [http://www-biology.ucsd.edu/faculty/johnson.html Randall S. Johnson, Ph.D.])
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*'''Post-Doctoral Research Associate; 2012 - 2013 ; [http://www.salk.edu Salk Institute for Biological Studies], California, USA (Supervisor; [https://sites.google.com/site/shawlaboratory/ '''Reuben Shaw, Ph.D.'''])
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===Academic Awards===
===Academic Awards===
*Achievement Award for the 1st rank in The Veterinary National Board Examination, Korea (2000)
*Achievement Award for the 1st rank in The Veterinary National Board Examination, Korea (2000)
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*Dean’s Award for Academic Achievement, summa cum laude, Kon-kuk University, School of Veterinary Medicine, Seoul, Korea (2000)
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*Dean’s Award for Academic Achievement, summa cum laude, [http://veterinary.konkuk.ac.kr Kon-kuk University, School of Veterinary Medicine], Seoul, Korea (2000)
*'''[http://www.hhmi.org Howard Hughes Medical Institute (HHMI)], Pre-Doctoral Fellowship (2003 - 2006)'''
*'''[http://www.hhmi.org Howard Hughes Medical Institute (HHMI)], Pre-Doctoral Fellowship (2003 - 2006)'''
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*Pathology Young Investigators’ day Award, Excellence in Basic Research, Dept. of Pathology, Johns Hopkins, School of Medicine (2004)
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*Pathology Young Investigators’ day Award, Excellence in Basic Research, [http://pathology.jhu.edu/department/pathbio.cfm Dept. of Pathology, Johns Hopkins, School of Medicine] (2004)
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*Keystone Symposia Scholarship, Metabolomics: From Bioenergetics to Apoptosis (2006)
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*[http://www.keystonesymposia.org Keystone Symposia] Scholarship, Metabolomics: From Bioenergetics to Apoptosis (2006)
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*'''[http://ww3.komen.org/home/ Susan G. Komen Foundation] Post-Doctoral Fellowship (2008)'''
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*[http://ww3.komen.org/home/ Susan G. Komen Foundation] Post-Doctoral Fellowship (2008)
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*NIH T32 Postdoctoral Fellowship (2010-2011)
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*NIH F32 Postdoctoral Fellowship (2011-2013)
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*[http://www.keystonesymposia.org Keystone Symposia] Scholarship, Advances in Hypoxia (2012)
===Publications [http://publicationslist.org/vetjayk (Link to Full Text)]===
===Publications [http://publicationslist.org/vetjayk (Link to Full Text)]===
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[[Image:NRCcover.gif|frame|200px|right|''Nature Reviews Cancer Cover Jan 2008'']]
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[[Image:cellcover.gif|frame|250px|right|''Cell Metabolism Cover Mar 2006'']]
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#Andrew Cowburn, Norihiko Takeda, Adam Boutin, '''Jung-whan Kim''', Jane Sterling, Manando Nakasaki, Mark Southwood, Ananda Goldrath, Colin Jamora, Victor Nizet, Edwin Chilvers and Randall Johnson. Differential Regulation of Systemic Arterial Pressure by the skin: role of HIF isoforms. '''''Submitted'''''
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#Jonathan Chou, Jeffrey Lin, Audrey Brenot, '''Jung-whan Kim''', Sylvain Provot, and Zena Werb. GATA3 Suppresses Metastasis and Modulates the Tumor Microenvironment by Regulating miR-29b Expression. '''''Nature Cell Biology, 15:201-213 (2013)'''''
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#'''Jung-whan Kim''', Colin Evans, Alexander Weidemann, Norihiko Takeda, Yun Sok Lee, Christian Stockmann, Cristina Branco-Price, Filip Branberg, Gustavo Leone, Michael Ostrowski and Randall Johnson. Loss of Fibroblast HIF-1a Accelerates Tumorigenesis. '''Cancer Research, 72:3187-3195 (2012)'''
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#Norihiko Takeda, Ellen L. O’Dea, Andrew Doedens, '''Jung-whan Kim''', Alexander Weidmann, Christian Stockmann, Masataka Asagiri, M. Selete Simon, Alexander Hoffmann and Randall S. Johnson. Differential activation and antagonistic function of HIF-a isoforms in macrophages are essential for NO homeostasis. '''Genes Dev. 24:491-501 (2010)'''
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#'''Jung-whan Kim''' and Randall S. Johnson. You Don't need a PHD to Grow a Tumor. '''Developmental Cell 16:781-2 (2009)'''
#Hosein Kouros-Mehr, '''Jung-whan Kim''', Seth K. Bechis, and Zena Werb. GATA-3 and the Regulation of the Mammary Luminal Cell Fate. '''Current Opinion in Cell Biology 20:164-170 (2008)'''
#Hosein Kouros-Mehr, '''Jung-whan Kim''', Seth K. Bechis, and Zena Werb. GATA-3 and the Regulation of the Mammary Luminal Cell Fate. '''Current Opinion in Cell Biology 20:164-170 (2008)'''
#Chi V. Dang, '''Jung-whan Kim''', Ping Gao, and Jason Yustein. The Interplay between MYC and HIF in Cancer. '''Nature Reviews Cancer 8:51-56 (2008)'''
#Chi V. Dang, '''Jung-whan Kim''', Ping Gao, and Jason Yustein. The Interplay between MYC and HIF in Cancer. '''Nature Reviews Cancer 8:51-56 (2008)'''
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#Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, '''Jung-whan Kim''', Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. '''Int. J. Cancer,94:500-507 (2001)'''
#Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, '''Jung-whan Kim''', Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. '''Int. J. Cancer,94:500-507 (2001)'''
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====Book Chapters====
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====[https://sites.google.com/site/jaykimlaboratory/ ''' Go to Jay Kim Lab Website''']====
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#Chi V. Dang, Ping Gao and '''Jung-whan Kim'''. The Warburg effect and tumor metabolism. '''Encyclopedia of CANCER In press'''
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Revision as of 00:12, 13 April 2013

Contents

Go to Jay Kim Lab Website

Jungwhan (Jay) Kim, D.V.M., Ph.D.

Assistant Professor

Department of Molecular and Cell Biology

The University of Texas at Dallas

800 W. Campbell Road, Room FO3.704G

Richardson TX 75080

Phone: 972-883-3502

Email: jay.kim@utdallas.edu

Jay Kim Lab Website


Academic Positions

  • Assistant Professor (2013 Apr - Present ): Department of Molecular and Cell Biology, University of Texas at Dallas, Texas, USA


Education and Professional Training


Academic Awards


Publications (Link to Full Text)

Nature Reviews Cancer Cover Jan 2008
Nature Reviews Cancer Cover Jan 2008
Cell Metabolism Cover Mar 2006
Cell Metabolism Cover Mar 2006
  1. Andrew Cowburn, Norihiko Takeda, Adam Boutin, Jung-whan Kim, Jane Sterling, Manando Nakasaki, Mark Southwood, Ananda Goldrath, Colin Jamora, Victor Nizet, Edwin Chilvers and Randall Johnson. Differential Regulation of Systemic Arterial Pressure by the skin: role of HIF isoforms. Submitted
  2. Jonathan Chou, Jeffrey Lin, Audrey Brenot, Jung-whan Kim, Sylvain Provot, and Zena Werb. GATA3 Suppresses Metastasis and Modulates the Tumor Microenvironment by Regulating miR-29b Expression. Nature Cell Biology, 15:201-213 (2013)
  3. Jung-whan Kim, Colin Evans, Alexander Weidemann, Norihiko Takeda, Yun Sok Lee, Christian Stockmann, Cristina Branco-Price, Filip Branberg, Gustavo Leone, Michael Ostrowski and Randall Johnson. Loss of Fibroblast HIF-1a Accelerates Tumorigenesis. Cancer Research, 72:3187-3195 (2012)
  4. Norihiko Takeda, Ellen L. O’Dea, Andrew Doedens, Jung-whan Kim, Alexander Weidmann, Christian Stockmann, Masataka Asagiri, M. Selete Simon, Alexander Hoffmann and Randall S. Johnson. Differential activation and antagonistic function of HIF-a isoforms in macrophages are essential for NO homeostasis. Genes Dev. 24:491-501 (2010)
  5. Jung-whan Kim and Randall S. Johnson. You Don't need a PHD to Grow a Tumor. Developmental Cell 16:781-2 (2009)
  6. Hosein Kouros-Mehr, Jung-whan Kim, Seth K. Bechis, and Zena Werb. GATA-3 and the Regulation of the Mammary Luminal Cell Fate. Current Opinion in Cell Biology 20:164-170 (2008)
  7. Chi V. Dang, Jung-whan Kim, Ping Gao, and Jason Yustein. The Interplay between MYC and HIF in Cancer. Nature Reviews Cancer 8:51-56 (2008)
  8. Jung-whan Kim, Ping Gao, Yen-Chun Liu, Gregg L. Semenza and Chi V. Dang. HIF-1 and dysregulated c-Myc cooperatively induce VEGF and metabolic switches, HK2 and PDK1. Mol. Cell. Biol. 27:7381-7393 (2007)
  9. Jung-whan Kim, Ping Gao, and Chi V. Dnag. Effects of hypoxia on tumor metabolism. Cancer and Metastasis Reviews. 26:291-8 (2007)
  10. Ryo Fukuda, Huafeng Zhang, Jung-whan Kim, Larissa Shimoda, Chi V. Dang, and Gregg L. Semenza. HIF-1 regulates cytochrome oxidase subunit composition to optimize the efficiency of respiration of hypoxic cells. Cell 129:111-122 (2007)
  11. Jung-whan Kim, and Chi V. Dang. Cancer's molecular sweet tooth and the Warburg effect. Cancer Research 66:8927-8930 (2006)
  12. Jung-whan Kim, Irina Tchernyshyov, Gregg L. Semenza, and Chi V. Dang. HIF-1-mediated expression of PDK: a metabolic switch required for cellular adaptation to hypoxia. Cell Metabolism, 3:177-185 (2006)
  13. Kathryn O'Donnell, Duonan Yu, Karen I. Zeller, Jung-whan Kim, Frederick Racke, Andrei Thomas-Tikhonenko and Chi V. Dang. Transferrin Receptor 1 is a direct Myc target gene required for cell cycle progression, Mol. Cell. Biol. 26:2373-2386 (2006)
  14. Rong Mao, Xiaowen Wang, Edward L. Spitznagel Jr., Laurence P. Frelin, Jason C. Ting, Huashi Ding, Jung-whan Kim, Ingo Ruczinski, Thomas J. Downey, and Jonathan Pevsner. Role of Gene Expression in the Developing Human Down Syndrome Brain and Heart. Genome Biology, 6:R107 (2005)
  15. Jung-whan Kim, Lawrence B. Gardner and Chi V. Dang. Oncogenic Alterations of Metabolism and the Warburg Effect. Drug Discovery Today: Disease Mechanisms, 2:233-235 (2005)
  16. Feng Li, Diane Wonsey, Young Ko, Kathryn O'Donnell, Karen I. Zeller, Jung-whan Kim, Jason Yustein, Linda A. Lee and Chi V. Dang. Myc stimulates mitochondrial biogenesis and nuclear encoded mitochondrial genes, Mol. Cell. Biol. 25: 6225-6234 (2005)
  17. Jung-whan Kim and Chi V. Dang. Multifaceted Roles of Glycolytic Enzymes. Trends in Biochemical Sciences, 30:142-150 (2005)
  18. Seung-Hoon Lee, Jung-whan Kim, Sun-Hee Oh, Yong-Jin Kim, Seung-Bae Rho, Kyungsook Park, Kui-Lea Park and Je-ho Lee. IFN-gamma/IRF-1-induced p27 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer. FEBS Letters,579:1027-1033 (2005)
  19. Jung-whan Kim, Karen I. Zeller, Yunyue Wang, Anil G. Jegga, Bruce J. Aronow, Kathryn A. O'Donnell, and Chi V. Dang. Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays. Mol. Cell. Biol. 24:5923-5936 (2004)
  20. Jung-whan Kim, Christopher W. Wong, Jeffery D. Goldsmith, C.Song, Weili Fu, Mary-Beth Allion, Meenhard Herlyn, Abu B. Al-Mehdi, and Ruth J. Muschel. Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells. Cancer Letters, 213:203-212 (2004)
  21. Seung-Hoon Lee, Jung-whan Kim, Yongsuk Cho, Sunhee Oh, Hanwoong Lee, Wei Zhang and Jeho Lee. Interferon Regulatory Factor 1 (IRF-1) Is a Mediator for Interferon-g-induced Attenuation of Telomerase Activity and Human Telomerase Reverse Transcriptase (hTERT) Expression. Oncogene,22:381-391 (2003)
  22. Seung-Hoon Lee, Wei Zhang, Jung-joo Choi, Yong-Suk Cho, Sun-Hee Lee, Jung-whan Kim, Limei Hu, Jie Xu, Jinsong Liu and Joho Lee. Overexpression of the Thymosin beta-10 Gene in Human Ovarian Cancer Cells Disrupts F-Actin Stress Fiber and Leads to Apoptosis. Oncogene,20:6700-6706 (2001)
  23. Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, Jung-whan Kim, Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. Int. J. Cancer,94:500-507 (2001)

Go to Jay Kim Lab Website

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