User:Jon Sack: Difference between revisions
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==Research interests== | ==Research interests== | ||
The goal of my research program is to develop inhibitors selective for ion channel subtypes, particularly voltage-gated potassium (Kv) channels, such that researchers may use them to identify channel subunits that generate native currents. Establishing the molecular identity of Kv channels has been a particularly challenging problem: mammalian Kv channels arise from a family of more than 40 genes, and Kv pore-forming subunits can assemble as heterotetramers. Despite substantial and enduring efforts, few modulators of Kv channel activity have been discovered that are highly selective between individual channel subtype. This is perhaps due to a high degree of sequence conservation between subfamily members in the transmembrane segments that are important for function. | |||
==Education== | ==Education== | ||
Revision as of 15:13, 15 May 2010
Research interests
The goal of my research program is to develop inhibitors selective for ion channel subtypes, particularly voltage-gated potassium (Kv) channels, such that researchers may use them to identify channel subunits that generate native currents. Establishing the molecular identity of Kv channels has been a particularly challenging problem: mammalian Kv channels arise from a family of more than 40 genes, and Kv pore-forming subunits can assemble as heterotetramers. Despite substantial and enduring efforts, few modulators of Kv channel activity have been discovered that are highly selective between individual channel subtype. This is perhaps due to a high degree of sequence conservation between subfamily members in the transmembrane segments that are important for function.
Education
- 2003 PhD, Stanford University, Department of Biological Sciences
- 1997, BA, Reed College, Major in Biochemistry
Institutional Affiliations
Founder
Institute for Design of Intelligent Drugs
Protean Research
941 Roble Ridge
Palo Alto, California 94306
650.384.5792 tel
650.716.5222 fax
jon (at) sack (at) ididrugs (dot) org
Assistant Professional Researcher
Department of Neurobiology, Physiology & Behavior
College of Biological Sciences
University of California
196 Briggs Hall
One Shields Avenue
Davis, California 95616
530.752.4131 tel
530.754.6079 fax
jsack (at) ucdavid (dot) edu
