User:Jesse D. Kirkpatrick/Notebook/Nikki and Jesse Research Proposal

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(Project Description/Abstract)
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Members of the TRP family, specifically TRPM8 and TRPV4, regulate oxidative phosphorylation via uncoupling protein 1 (UCP1). TRPM8 positively regulates UCP1 and TRPV4 negatively regulates it via inhibition of PGC1-alpha. Uncoupling protein 1 is a major source of thermogenesis, and overexpression of this protein has provided hope for treating obesity and other metabolic conditions. However, the thermogenesis potential of this protein may itself be used as a local heating source, if overexpressed to an appropriate extent. We propose seeding bacteria in a cell and overepxressing UCP1 via TRPV4 inhibition and TRPM8 activation.
Members of the TRP family, specifically TRPM8 and TRPV4, regulate oxidative phosphorylation via uncoupling protein 1 (UCP1). TRPM8 positively regulates UCP1 and TRPV4 negatively regulates it via inhibition of PGC1-alpha. Uncoupling protein 1 is a major source of thermogenesis, and overexpression of this protein has provided hope for treating obesity and other metabolic conditions. However, the thermogenesis potential of this protein may itself be used as a local heating source, if overexpressed to an appropriate extent. We propose seeding bacteria in a cell and overepxressing UCP1 via TRPV4 inhibition and TRPM8 activation.
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==Notes==
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==References==
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* Place some notes here for visitors
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Ye et al. TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis.(2012) Cell Press.151(1): 96-110
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* Example: This project is currently on hold until further notice.
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Ma et al. Activation of the cold-sensing TRPM8 channel triggers UCPI-dependent thermogenesis and prevents obesity. (2012) Journal of Molecular Cell Biology. 4: 88-96
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Revision as of 12:56, 7 May 2013

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Project Description/Abstract

This project will focus on harnessing the power of bacteria to generate heat by turning on and off gene expression and ultimately overepxressing one of the uncoupling proteins involved in deregulating oxidative phosphorylation.

Members of the TRP family, specifically TRPM8 and TRPV4, regulate oxidative phosphorylation via uncoupling protein 1 (UCP1). TRPM8 positively regulates UCP1 and TRPV4 negatively regulates it via inhibition of PGC1-alpha. Uncoupling protein 1 is a major source of thermogenesis, and overexpression of this protein has provided hope for treating obesity and other metabolic conditions. However, the thermogenesis potential of this protein may itself be used as a local heating source, if overexpressed to an appropriate extent. We propose seeding bacteria in a cell and overepxressing UCP1 via TRPV4 inhibition and TRPM8 activation.

References

Ye et al. TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis.(2012) Cell Press.151(1): 96-110

Ma et al. Activation of the cold-sensing TRPM8 channel triggers UCPI-dependent thermogenesis and prevents obesity. (2012) Journal of Molecular Cell Biology. 4: 88-96

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