User:Jayajit Das

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<!-- Delete this entire line as part of your first edit of your user page --> {{New user}}
 
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==Contact Info==
==Contact Info==
[[Image:Jayajit.jpg|thumb|right|]]  
[[Image:Jayajit.jpg|thumb|right|]]  
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Battelle Center for Mathematical Medicine<br />
Battelle Center for Mathematical Medicine<br />
The Research Institute at Nationwide Children's Hospital<br />
The Research Institute at Nationwide Children's Hospital<br />
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Biophysics Graduate Program and Department of Pediatrics<br />
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Departments of Pediatrics, Physics, Integrated Biomedical Sciences, and Biophysics Graduate Program<br />
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Ohio State University, Columbus, OH 43205<br />   
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The Ohio State University, Columbus, OH 43205<br />   
'''Email''': das.70 @ osu.edu; jayajit.das @ nationwidechildrens.org ; jayajit @ gmail.com <br />
'''Email''': das.70 @ osu.edu; jayajit.das @ nationwidechildrens.org ; jayajit @ gmail.com <br />
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'''Phone''': 614-355-4526 (work)<br />
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'''Phone''': 614-355-5632 (work)<br />
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'''Fax''':  614-355-2728
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'''Fax''':  614-355-2928
==Education and Professional Experience==
==Education and Professional Experience==
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My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response.  Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.
My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response.  Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.
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== Lab members ==
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Sayak Mukherjee (Ph.D Physics, V.Tech) Postdoc <br />
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Aleya Dhanji Graduate student, OSU Physics Department  <br />
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Arjun Venkataraman (High School Research Project) <br />
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== Lab Alumni ==
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Michael Dworkin (Math Major, OSU) Undergraduate student <br />
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Current Position: Merrimack Pharmaceuticals, Inc <br />
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Birra Abdurehman (Math Major, OSU) Undergraduate student <br />
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Jagadish Kumar (Postdoc) 2010-2011 <br />
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Mithila Agnihotri Graduate student, OSU Biophysics Program  <br />
==Selected Publications==
==Selected Publications==
<biblio>
<biblio>
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#Paper1 Jayajit Das, Mary Ho, Julie Zikherman, Christopher Govern, Ming Yang, Arthur Weiss, Arup K. Chakraborty and Jeroen Roose, ''Digital signaling and hystersis characterize ras activation in lymphocytes'' Cell, accepted for publication, 2008.
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#Paper1 pmid=23298061
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#Paper2 Ashok Prasad, Julie Zikherman, Jayajit Das, Jeroen Roose, Arthur Weiss and Arup K. Chakraborty, ''Origin of analog and digital thresholds for positive and negative selection of T cells in the thymus''  PNAS, accepted for publication, 2008.
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#Paper2 pmid=23281368
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#Paper3 pmid=18760640
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#Paper3 pmid=22378749
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#Paper4 pmid=18025473
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#Paper4 pmid=20923636
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#Paper5 pmid=17360359
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#Paper5 pmid=20029448
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#Paper6 pmid=17346997
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#Paper6 pmid=19566183
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#Paper7 pmid=19366993
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#Paper8 pmid=19167334
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#Paper9 pmid=19098101
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#Paper10 pmid=18760640
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#Paper11 pmid=18025473
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#Paper12 pmid=17360359
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#Paper13 pmid=17346997
</biblio>
</biblio>
==Useful links==
==Useful links==
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*[[OpenWetWare:Welcome|Introductory tutorial]]
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[url=http://www3.clustrmaps.com/user/b259054d][img]http://www3.clustrmaps.com/stats/maps-no_clusters/--openwetware.org-wiki-User-Jayajit_Das-thumb.jpg[/img][/url]
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*[[Help|OpenWetWare help pages]]
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*More details at http://www.mathmed.org/#Jayajit_Das
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==Jobs==
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'''Graduate Student''': Students with a background in Physics, Mathematics, Chemistry, Computer Science or Chemical Engineering are encouraged to apply.

Revision as of 14:35, 10 January 2013

Contents

Contact Info

  • Jayajit Das

Assistant Professor
Battelle Center for Mathematical Medicine
The Research Institute at Nationwide Children's Hospital
Departments of Pediatrics, Physics, Integrated Biomedical Sciences, and Biophysics Graduate Program
The Ohio State University, Columbus, OH 43205

Email: das.70 @ osu.edu; jayajit.das @ nationwidechildrens.org ; jayajit @ gmail.com
Phone: 614-355-5632 (work)
Fax: 614-355-2928

Education and Professional Experience

  • 2005-2008 Postdoctoral Fellow, Massachusetts Institute of Technology
  • 2002-2005 Postdoctoral Fellow, University of California at Berkeley
  • 2000-2002 Postdoctoral Fellow, Virginia Institute of Polytechnic and State University
  • 2000 Ph.D. Physics, Raman Research Institute, Bangalore, India
  • 1996 M.Sc. Physics, Institute of Mathematical Sciences, Chennai (Madras) India
  • 1994 B.Sc. Physics, Presidency College, Kolkata(Calcutta), India

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

Lab members

Sayak Mukherjee (Ph.D Physics, V.Tech) Postdoc
Aleya Dhanji Graduate student, OSU Physics Department
Arjun Venkataraman (High School Research Project)

Lab Alumni

Michael Dworkin (Math Major, OSU) Undergraduate student
Current Position: Merrimack Pharmaceuticals, Inc

Birra Abdurehman (Math Major, OSU) Undergraduate student
Jagadish Kumar (Postdoc) 2010-2011

Mithila Agnihotri Graduate student, OSU Biophysics Program

Selected Publications

  1. Das J. . pmid:23298061. PubMed HubMed [Paper1]
  2. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, and Weiss A. . pmid:23281368. PubMed HubMed [Paper2]
  3. Dworkin M, Mukherjee S, Jayaprakash C, and Das J. . pmid:22378749. PubMed HubMed [Paper3]
  4. Das J. . pmid:20923636. PubMed HubMed [Paper4]
  5. Chakraborty AK and Das J. . pmid:20029448. PubMed HubMed [Paper5]
  6. Das J, Kardar M, and Chakraborty AK. . pmid:19566183. PubMed HubMed [Paper6]
  7. Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, and Roose J. . pmid:19366993. PubMed HubMed [Paper7]
  8. Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, and Roose JP. . pmid:19167334. PubMed HubMed [Paper8]
  9. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, and Chakraborty AK. . pmid:19098101. PubMed HubMed [Paper9]
  10. Cemerski S, Das J, Giurisato E, Markiewicz MA, Allen PM, Chakraborty AK, and Shaw AS. . pmid:18760640. PubMed HubMed [Paper10]
  11. Artyomov MN, Das J, Kardar M, and Chakraborty AK. . pmid:18025473. PubMed HubMed [Paper11]
  12. Wylie DC, Das J, and Chakraborty AK. . pmid:17360359. PubMed HubMed [Paper12]
  13. Cemerski S, Das J, Locasale J, Arnold P, Giurisato E, Markiewicz MA, Fremont D, Allen PM, Chakraborty AK, and Shaw AS. . pmid:17346997. PubMed HubMed [Paper13]
All Medline abstracts: PubMed HubMed

Useful links

[url=http://www3.clustrmaps.com/user/b259054d][img]--openwetware.org-wiki-User-Jayajit_Das-thumb.jpg[/img][/url]

Jobs

Graduate Student: Students with a background in Physics, Mathematics, Chemistry, Computer Science or Chemical Engineering are encouraged to apply.

Personal tools