User:Jayajit Das

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==Selected Publications==
==Selected Publications==
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#Paper1 Jayajit Das, Mary Ho, Julie Zikherman, Christopher Govern, Ming Yang, Arthur Weiss, Arup K. Chakraborty and Jeroen Roose, ''Digital signaling and hystersis characterize ras activation in lymphocytes'' Cell, accepted for publication, 2008.
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#Paper1 Jayajit Das, Mary Ho, Julie Zikherman, Christopher Govern, Ming Yang, Arthur Weiss, Arup K. Chakraborty and Jeroen Roose, ''Digital signaling and hystersis characterize ras activation in lymphocytes'' Cell, vol. 136, p. 337 (2009).
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#Paper2 Ashok Prasad, Julie Zikherman, Jayajit Das, Jeroen Roose, Arthur Weiss and Arup K. Chakraborty, ''Origin of analog and digital thresholds for positive and negative selection of T cells in the thymus''  PNAS, accepted for publication, 2008.
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#Paper2 pmid=19098101
#Paper3 pmid=18760640
#Paper3 pmid=18760640
#Paper4 pmid=18025473  
#Paper4 pmid=18025473  

Revision as of 10:54, 23 January 2009

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Contents

Contact Info

  • Jayajit Das

Assistant Professor
Battelle Center for Mathematical Medicine
The Research Institute at Nationwide Children's Hospital
Biophysics Graduate Program and Department of Pediatrics
Ohio State University, Columbus, OH 43205

Email: das.70 @ osu.edu; jayajit.das @ nationwidechildrens.org ; jayajit @ gmail.com
Phone: 614-355-4526 (work)
Fax: 614-355-2728

Education and Professional Experience

  • 2005-2008 Postdoctoral Fellow, Massachusetts Institute of Technology
  • 2002-2005 Postdoctoral Fellow, University of California at Berkeley
  • 2000-2002 Postdoctoral Fellow, Virginia Institute of Polytechnic and State University
  • 2000 Ph.D. Physics, Raman Research Institute, Bangalore, India
  • 1996 M.Sc. Physics, Institute of Mathematical Sciences, Chennai (Madras) India
  • 1994 B.Sc. Physics, Presidency College, Kolkata(Calcutta), India

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

Selected Publications

  1. Jayajit Das, Mary Ho, Julie Zikherman, Christopher Govern, Ming Yang, Arthur Weiss, Arup K. Chakraborty and Jeroen Roose, Digital signaling and hystersis characterize ras activation in lymphocytes Cell, vol. 136, p. 337 (2009). [Paper1]
  2. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, and Chakraborty AK. . pmid:19098101. PubMed HubMed [Paper2]
  3. Cemerski S, Das J, Giurisato E, Markiewicz MA, Allen PM, Chakraborty AK, and Shaw AS. . pmid:18760640. PubMed HubMed [Paper3]
  4. Artyomov MN, Das J, Kardar M, and Chakraborty AK. . pmid:18025473. PubMed HubMed [Paper4]
  5. Wylie DC, Das J, and Chakraborty AK. . pmid:17360359. PubMed HubMed [Paper5]
  6. Cemerski S, Das J, Locasale J, Arnold P, Giurisato E, Markiewicz MA, Fremont D, Allen PM, Chakraborty AK, and Shaw AS. . pmid:17346997. PubMed HubMed [Paper6]
All Medline abstracts: PubMed HubMed

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