User:Jason R. Kelly
Bio
2nd Year Biological Engineering Graduate Student @ MIT
S.B. in Biology and Chemical Enginneering @ MIT, 2003
Project
Abstract
To date, engineered biological systems have been produced via a variety of ad hoc approaches. The resulting systems should be thought of as pieces of art. Here, I propose to explore how past and new engineering approaches might be used to make routine the engineering of integrated genetic systems.
Work at MIT and by others has laid the foundation for an engineering framework to assemble multi-component systems from standard genetic parts. To support this effort a Registry of Standard Biological Parts has been organized (http://parts.mit.edu/). However, most work thus far has not made good use of inherent advantages of engineering in a biological substrate, namely generation of diversity and evolution. My goal is to couple the forward engineering strategy of the Parts Registry with library generation and directed evolution in an effort to solve the problems preventing routine construction of genetic systems.
Specific Aims
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