User:Jarle Pahr/Synthetic biology
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Revision as of 17:36, 24 April 2013
Notes on news and articles related to synthetic biology:
RNA-guided editing of bacterial genomes using CRISPR-Cas systems: http://www.nature.com/nbt/journal/v31/n3/full/nbt.2508.html
Amplifying genetic logic gates: http://www.sciencemag.org/content/early/2013/03/27/science.1232758.abstract
RNA processing enables predictable programming of gene expression: http://www.nature.com/nbt/journal/v30/n10/full/nbt.2355.html
Ribozyme-based insulator parts: http://www.nature.com/nbt/journal/v30/n11/full/nbt.2401.html?WT.ec_id=NBT-201211
Organizations and websites
Blogs and commentary
Polymerases per second (POPS):
A biological PID? Input and the objective to be controlled could be levels of a protein or a metabolite. Output would be summed from the activity of three transcription units. Would need a way to create a set-point and convert the difference between the present level and the set-point to serve as input to the PID circuit.
- Proportional term. Activity is proportional to input (current level).
- Integrative term. Activity is proportional to the total input over a recent timeframe (how can this be achieved?)
- Derivative term. Activity is proportional to the change in input over a recent timeframe (how can this be achieved?)
Might be helpful to study mechanical or analog PID circuits.