My personal research interest has been the understanding of biological mechanisms within the context of reduced systems, namely in vitro transcription and translation systems. My interest is in learning about other contexts in which reduced systems might find applications. Currently, we are investigating how to utilize such systems to gain insight into RNA function, in particular RNA network motifs.
Education and Career
Post Doc with Prof. Julius Lucks at Chemical and Biomedical Engineering, Cornell University
PhD with Prof. Paul Freemont at Center for Synthetic Biology and Innovation, Imperial College London
1st Class Honours Bsc in Biochemistry, Imperial College London
Scientific Publications
Chappell,J., Takashashi, M. K., Meyer,S., Loughrey, D., Watters, K., Lucks,J. B. The Centrality of RNA for Engineering Gene Expression. Biotechnology Journal, 2013. DOI: 10.1002/biot.201300018 (FREE)
[1]
Chappell, J., Jensen, K., and Freemont, P.S. (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Res. Pubmed
[2]
Chappell, J. Freemont, P.S. SYNTHETIC BIOLOGY—A NEW GENERATION OF BIOFILM BIOSENSORS. Pubmed Books
[3]
Gulati1, S. Rouilly, V. Niu1, X. Chappell, J. Kitney, R. Edel, J. Freemont, P. A, deMello.Opportunities for microfluidic technologies in synthetic biology. Pubmed
[4]
Contact Details
James Chappell,
120 Olin Hall,
Chemical and Biomolecular Engineering
Cornell,
NY, USA
