User:James Chappell: Difference between revisions

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<font face="trebuchet ms" style="color:#FFFFFF" size="6">'''James Chappell'''</font><br>
<font face="trebuchet ms" style="color:#FFFFFF" size="6">'''James Chappell'''</font><br>
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<font face="trebuchet ms" style="color:#FFFFFF" size="3">'''Imperial College London Synthetic Biology Lab'''</font><br>
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=== Research Interests ===
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I am currently working as a postdoctoral researcher with Prof. Julius Lucks (Lucks Lab) at Cornell University in the School of Chemical and Biomolecular Engineering. I previously obtained a  BSc degree in Biochemistry at Imperial College London, where I continued as a PhD student in Molecular Biosciences under the supervision of Prof. Paul Freemont working at the Imperial College Center for Synthetic Biology and Innovation. My research interests are broadly focused in Synthetic Biology.
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===Publications===


1. S. Meyer, J. Chappell, S. Sankar, R Chew, J. B. Lucks* (2015). Improving fold activation of small transcription activating RNAs (STARs) with rational RNA engineering strategies. Biotechnology and Bioengineering. 36, 154-160.


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2. J. Chappell, K. E. Watters, M. K. Takahashi, J. B. Lucks* (2015). A Renaissance in RNA Synthetic Biology: New Mechanisms, Applications and Tools for the Future. Current Opinion in Chemical Biology. 28, 47-56.


===Current Project===
3. M. K. Takahashi, C. A. Hayes, J. Chappell, Z. Z. Sun, R. M. Murray, V. Noireaux, J. B. Lucks* (2015). Characterizing and Prototyping Genetic Networks with Cell-Free Transcription-Translation Reactions. Methods. Doi: 10.1016/j.ymeth.2015.05.020.


Currently a 1st year PhD student at Imperial College Synthetic Biology Lab. My project title at the moment is to investigate "A 
Synthetic 
Biology 
Approach 
to
 the 
Development 
of 
Biosensors 
for 
the
 Detection
 of 
Pathogenic 
Biofilms
."
4. J. Chappell, M. K. Takahashi, J. B. Lucks* (2015). Creating Small Transcription Activating RNAs. Nature Chemical Biology, 11, 214-220.  


===Education===
5. M. K. Takahashi, J. Chappell, C. A. Hayes, Z. Z. Sun, J. Kim, V. Singhal, K. J. Spring, S. Al-Khabouri, C. P. Fall, V. Noireaux, R. M. Murray, J. B. Lucks* (2014). Rapidly characterizing the fast dynamics of RNA genetic circuitry with in vitro transcription-translation (TX-TL) reactions. ACS Synthetic Biology, 15, 503-515.


1st Class Honours Bsc in Biochemistry, Imperial College London
6. J. Chappell, M. K. Takahashi, S. Meyer, D. Loughrey, K. E. Watters, J. B. Lucks* (2013). The Centrality of RNA for Engineering Gene Expression. Biotechnology Journal, 8, 1379-1395.


===Previous Projects===
7. J. Chappell, K. Jensen, P.S. Freemont* (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Research, 41, 3471-3481.


Member of Imperial College iGEM team 2008 - Biofabricator subtilis Project
8. J. Chappell, P. S. Freemont* (2013). In Vivo and In Vitro Characterization of σ 70 Constitutive Promoters by Real-Time PCR and Fluorescent Measurements. Methods in Molecular Biology – Synthetic Biology, 61-74.
*Gold Medal Winner
*Winner of Best New Natural BioBrick Part
*Winner of Best Manufacturing Project
Member of Imperial College iGEM team 2007 - Infector Detector Project
*Gold Medal Winner


===Interests===
9. J. Chappell, P. S. Freemont* (2013). Synthetic biology – A new generation of biofilm biosensors


*Biosensors
10. S. Gulati, V. Rouilly, X. Niu, J. Chappell, R. I. Kitney, J. B. Edel, P. S. Freemont and A. J. deMello (2009). Opportunities for microfluidic technologies in synthetic biology. Journal of The Royal Society Interface, 6, 493-506
*Aptamers
*Cell-Free expression systems
*DNA assembly techniques
*High throughput characterization techniques


===Contact Details===
===Contact Details===
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James Chappell, <br>
James Chappell, <br>
Synthetic Biology Lab, <br>  
120 Olin Hall, <br>  
Division of Molecular Biosciences <br>
Chemical and Biomolecular Engineering <br>
Imperial College London, <br>
Cornell, <br>
London, UK <br>
NY, USA <br>
<br>
<br>
Email - jchappell105@gmail.com
Email - jchappell105@gmail.com


===Links===
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[[User:James_Chappell_/My_Sandbox| <font color="white> My Sandbox </font>]]
 
[[User:James_Chappell_/R_RK4_Modeling| <font color="white> Using R Program an the RK4 function for modeling gene expression using ODE models </font>]]
 
 
[http://2008.igem.org/Team:Imperial_College <font color="white">Imperial College London iGEM 2008 wiki</font>]
 
[http://parts.mit.edu/igem07/index.php/Imperial <font color="white">Imperial College London iGEM 2007 wiki</font>]

Revision as of 16:55, 16 November 2015

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James Chappell

Research Interests

I am currently working as a postdoctoral researcher with Prof. Julius Lucks (Lucks Lab) at Cornell University in the School of Chemical and Biomolecular Engineering. I previously obtained a BSc degree in Biochemistry at Imperial College London, where I continued as a PhD student in Molecular Biosciences under the supervision of Prof. Paul Freemont working at the Imperial College Center for Synthetic Biology and Innovation. My research interests are broadly focused in Synthetic Biology.



Publications

1. S. Meyer, J. Chappell, S. Sankar, R Chew, J. B. Lucks* (2015). Improving fold activation of small transcription activating RNAs (STARs) with rational RNA engineering strategies. Biotechnology and Bioengineering. 36, 154-160.

2. J. Chappell, K. E. Watters, M. K. Takahashi, J. B. Lucks* (2015). A Renaissance in RNA Synthetic Biology: New Mechanisms, Applications and Tools for the Future. Current Opinion in Chemical Biology. 28, 47-56.

3. M. K. Takahashi, C. A. Hayes, J. Chappell, Z. Z. Sun, R. M. Murray, V. Noireaux, J. B. Lucks* (2015). Characterizing and Prototyping Genetic Networks with Cell-Free Transcription-Translation Reactions. Methods. Doi: 10.1016/j.ymeth.2015.05.020.

4. J. Chappell, M. K. Takahashi, J. B. Lucks* (2015). Creating Small Transcription Activating RNAs. Nature Chemical Biology, 11, 214-220.

5. M. K. Takahashi, J. Chappell, C. A. Hayes, Z. Z. Sun, J. Kim, V. Singhal, K. J. Spring, S. Al-Khabouri, C. P. Fall, V. Noireaux, R. M. Murray, J. B. Lucks* (2014). Rapidly characterizing the fast dynamics of RNA genetic circuitry with in vitro transcription-translation (TX-TL) reactions. ACS Synthetic Biology, 15, 503-515.

6. J. Chappell, M. K. Takahashi, S. Meyer, D. Loughrey, K. E. Watters, J. B. Lucks* (2013). The Centrality of RNA for Engineering Gene Expression. Biotechnology Journal, 8, 1379-1395.

7. J. Chappell, K. Jensen, P.S. Freemont* (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Research, 41, 3471-3481.

8. J. Chappell, P. S. Freemont* (2013). In Vivo and In Vitro Characterization of σ 70 Constitutive Promoters by Real-Time PCR and Fluorescent Measurements. Methods in Molecular Biology – Synthetic Biology, 61-74.

9. J. Chappell, P. S. Freemont* (2013). Synthetic biology – A new generation of biofilm biosensors

10. S. Gulati, V. Rouilly, X. Niu, J. Chappell, R. I. Kitney, J. B. Edel, P. S. Freemont and A. J. deMello (2009). Opportunities for microfluidic technologies in synthetic biology. Journal of The Royal Society Interface, 6, 493-506

Contact Details


James Chappell,
120 Olin Hall,
Chemical and Biomolecular Engineering
Cornell,
NY, USA

Email - jchappell105@gmail.com

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