User:James Chappell

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(Scientific Publications)
 
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<font face="trebuchet ms" style="color:#FFFFFF" size="6">'''James Chappell'''</font><br>
<font face="trebuchet ms" style="color:#FFFFFF" size="6">'''James Chappell'''</font><br>
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=== Research Interests ===
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My personal research interest has been the understanding of biological gene regulation mechanisms within the context of reduced systems, namely in vitro transcription and translation systems. My interest is in learning about other contexts in which reduced systems might find applications. Currently, we are investigating how to utilize such systems to gain insight into RNA function, in particular RNA network motifs.
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===Interests===
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*Biosensors
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*Aptamers
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*Cell-Free expression systems
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*DNA assembly techniques
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===Education and Career===
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*High throughput characterization techniques
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*Post Doc with Prof. Julius Lucks at Chemical and Biomedical Engineering, Cornell University
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*PhD with Prof. Paul Freemont at Center for Synthetic Biology and Innovation, Imperial College London <br>
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*1st Class Honours Bsc in Biochemistry, Imperial College London <br>
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===Education===
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1st Class Honours Bsc in Biochemistry, Imperial College London <br>
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PhD with Prof. Paul Freemont at Center for Synthetic Biology and Innovation, Imperial College London
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===Scientific Publications===
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===Research Projects===
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<biblio>
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====PhD Project====
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# 1 Melissa K Takahashi, James Chappell, Clarmyra A Hayes, Zachary Z Sun, Jongmin Kim, Vipul Singhal, Kevin J Spring, Shaima Al-Khabouri, Christopher P Fall, Vincent Noireaux, Richard M. Murray, and Julius B. Lucks."Rapidly characterizing the fast dynamics of RNA genetic circuitry with cell-free transcription-translation (TX-TL) systems. " ACS Synthetic Biology, 2014. DOI: 10.1021/sb400206c
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Cell-free Systems for Synthetic Biology:Development of Characterisation Tools and Biosensors
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====Other Research:====
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# 2 Chappell,J., Takashashi, M. K.,  Meyer,S., Loughrey, D., Watters, K., Lucks,J. B.  ''The Centrality of RNA for Engineering Gene Expression.'' Biotechnology Journal, 2013. DOI: 10.1002/biot.201300018 (FREE)
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Adviser of Imperial College iGEM team 2009 - The E.ncapsulator
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*Gold Medal Winner
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*Winner of Best Manufacturing Project
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*Winner of Best Ethics project
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Member of Imperial College iGEM team 2008 - Biofabricator subtilis Project
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*Gold Medal Winner
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*Winner of Best New Natural BioBrick Part
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*Winner of Best Manufacturing Project
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Member of Imperial College iGEM team 2007 - Infector Detector Project
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*Gold Medal Winner
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===Awards===
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# 3 Chappell, J., Jensen, K., and Freemont, P.S. (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Res. [http://www.ncbi.nlm.nih.gov/pubmed/23371936 Pubmed]
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===Publications===
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# 4 Chappell, J. Freemont, P.S. SYNTHETIC BIOLOGY—A NEW GENERATION OF BIOFILM BIOSENSORS. [http://www.ncbi.nlm.nih.gov/books/NBK84447/ Pubmed Books]
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<biblio>
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# 5 Gulati1, S. Rouilly, V. Niu1, X. Chappell, J. Kitney, R. Edel, J. Freemont, P. A, deMello.Opportunities for microfluidic technologies in synthetic biology. [http://www.ncbi.nlm.nih.gov/pubmed/19474079 Pubmed]
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# 1 Chappell, J., Jensen, K., and Freemont, P.S. (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Res. [http://www.ncbi.nlm.nih.gov/pubmed/23371936 Pubmed]
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</biblio>
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===Contact Details===
===Contact Details===
James Chappell, <br>
James Chappell, <br>
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Synthetic Biology Lab, <br>  
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120 Olin Hall, <br>  
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Division of Molecular Biosciences <br>
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Chemical and Biomolecular Engineering <br>
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Imperial College London, <br>
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Cornell, <br>
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London, UK <br>
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NY, USA <br>
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Email - jchappell105@gmail.com
Email - jchappell105@gmail.com
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Current revision


James Chappell

Research Interests

My personal research interest has been the understanding of biological gene regulation mechanisms within the context of reduced systems, namely in vitro transcription and translation systems. My interest is in learning about other contexts in which reduced systems might find applications. Currently, we are investigating how to utilize such systems to gain insight into RNA function, in particular RNA network motifs.



Education and Career

  • Post Doc with Prof. Julius Lucks at Chemical and Biomedical Engineering, Cornell University
  • PhD with Prof. Paul Freemont at Center for Synthetic Biology and Innovation, Imperial College London
  • 1st Class Honours Bsc in Biochemistry, Imperial College London

Scientific Publications

  1. Melissa K Takahashi, James Chappell, Clarmyra A Hayes, Zachary Z Sun, Jongmin Kim, Vipul Singhal, Kevin J Spring, Shaima Al-Khabouri, Christopher P Fall, Vincent Noireaux, Richard M. Murray, and Julius B. Lucks."Rapidly characterizing the fast dynamics of RNA genetic circuitry with cell-free transcription-translation (TX-TL) systems. " ACS Synthetic Biology, 2014. DOI: 10.1021/sb400206c [1]
  2. Chappell,J., Takashashi, M. K., Meyer,S., Loughrey, D., Watters, K., Lucks,J. B. The Centrality of RNA for Engineering Gene Expression. Biotechnology Journal, 2013. DOI: 10.1002/biot.201300018 (FREE) [2]
  3. Chappell, J., Jensen, K., and Freemont, P.S. (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Res. Pubmed [3]
  4. Chappell, J. Freemont, P.S. SYNTHETIC BIOLOGY—A NEW GENERATION OF BIOFILM BIOSENSORS. Pubmed Books [4]
  5. Gulati1, S. Rouilly, V. Niu1, X. Chappell, J. Kitney, R. Edel, J. Freemont, P. A, deMello.Opportunities for microfluidic technologies in synthetic biology. Pubmed [5]

Contact Details

James Chappell,
120 Olin Hall,
Chemical and Biomolecular Engineering
Cornell,
NY, USA

Email - jchappell105@gmail.com

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