User:James Chappell

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<font face="trebuchet ms" style="color:#FFFFFF" size="6">'''James Chappell'''</font><br>
<font face="trebuchet ms" style="color:#FFFFFF" size="6">'''James Chappell'''</font><br>
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<font face="trebuchet ms" style="color:#FFFFFF" size="3">'''Imperial College London Synthetic Biology Lab'''</font><br>
 
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=== Research Interests ===
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===Education===
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I am currently working as a postdoctoral researcher with Prof. Julius Lucks (Lucks Lab) at Cornell University in the School of Chemical and Biomolecular Engineering. I previously obtained a  BSc degree in Biochemistry at Imperial College London, where I continued as a PhD student in Molecular Biosciences under the supervision of Prof. Paul Freemont working at the Imperial College Center for Synthetic Biology and Innovation. My research interests are broadly focused in Synthetic Biology.
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1st Class Honours Bsc in Biochemistry, Imperial College London
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===Research Projects===
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[[Image: nfig001.jpg|center|500px]]<br clear = "all">
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===PhD Project===
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Cell-free Systems for Synthetic Biology:Development of Characterisation Tools and Biosensors
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====iGEM:====
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Adviser of Imperial College iGEM team 2009 - The E.ncapsulator
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*Gold Medal Winner
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*Winner of Best Manufacturing Project
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*Winner of Best Ethics project
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Member of Imperial College iGEM team 2008 - Biofabricator subtilis Project
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*Gold Medal Winner
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*Winner of Best New Natural BioBrick Part
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*Winner of Best Manufacturing Project
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Member of Imperial College iGEM team 2007 - Infector Detector Project
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*Gold Medal Winner
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===Publications===
===Publications===
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<biblio>
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1. S. Meyer, J. Chappell, S. Sankar, R Chew, J. B. Lucks* (2015). Improving fold activation of small transcription activating RNAs (STARs) with rational RNA engineering strategies. Biotechnology and Bioengineering. 36, 154-160.
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1 pmid=23371936
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2. J. Chappell, K. E. Watters, M. K. Takahashi, J. B. Lucks* (2015). A Renaissance in RNA Synthetic Biology: New Mechanisms, Applications and Tools for the Future. Current Opinion in Chemical Biology. 28, 47-56.
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===Interests===
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3. M. K. Takahashi, C. A. Hayes, J. Chappell, Z. Z. Sun, R. M. Murray, V. Noireaux, J. B. Lucks* (2015). Characterizing and Prototyping Genetic Networks with Cell-Free Transcription-Translation Reactions. Methods. Doi: 10.1016/j.ymeth.2015.05.020.
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*Biosensors
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4. J. Chappell, M. K. Takahashi, J. B. Lucks* (2015). Creating Small Transcription Activating RNAs. Nature Chemical Biology, 11, 214-220.
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*Aptamers
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*Cell-Free expression systems
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5. M. K. Takahashi, J. Chappell, C. A. Hayes, Z. Z. Sun, J. Kim, V. Singhal, K. J. Spring, S. Al-Khabouri, C. P. Fall, V. Noireaux, R. M. Murray, J. B. Lucks* (2014). Rapidly characterizing the fast dynamics of RNA genetic circuitry with in vitro transcription-translation (TX-TL) reactions. ACS Synthetic Biology, 15, 503-515.
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*DNA assembly techniques
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*High throughput characterization techniques
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6. J. Chappell, M. K. Takahashi, S. Meyer, D. Loughrey, K. E. Watters, J. B. Lucks* (2013). The Centrality of RNA for Engineering Gene Expression. Biotechnology Journal, 8, 1379-1395.
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7. J. Chappell, K. Jensen, P.S. Freemont* (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Research, 41, 3471-3481.
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8. J. Chappell, P. S. Freemont* (2013). In Vivo and In Vitro Characterization of σ 70 Constitutive Promoters by Real-Time PCR and Fluorescent Measurements. Methods in Molecular Biology – Synthetic Biology, 61-74.
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9. J. Chappell, P. S. Freemont* (2013). Synthetic biology – A new generation of biofilm biosensors
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10. S. Gulati, V. Rouilly, X. Niu, J. Chappell, R. I. Kitney, J. B. Edel, P. S. Freemont and A. J. deMello (2009). Opportunities for microfluidic technologies in synthetic biology. Journal of The Royal Society Interface, 6, 493-506
===Contact Details===
===Contact Details===
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[[Image: PhotoJim.jpg|left|150px]]<br clear = "all">
James Chappell, <br>
James Chappell, <br>
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Synthetic Biology Lab, <br>  
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120 Olin Hall, <br>  
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Division of Molecular Biosciences <br>
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Chemical and Biomolecular Engineering <br>
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Imperial College London, <br>
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Cornell, <br>
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London, UK <br>
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NY, USA <br>
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Email - jchappell105@gmail.com
Email - jchappell105@gmail.com
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Current revision


James Chappell

Research Interests

I am currently working as a postdoctoral researcher with Prof. Julius Lucks (Lucks Lab) at Cornell University in the School of Chemical and Biomolecular Engineering. I previously obtained a BSc degree in Biochemistry at Imperial College London, where I continued as a PhD student in Molecular Biosciences under the supervision of Prof. Paul Freemont working at the Imperial College Center for Synthetic Biology and Innovation. My research interests are broadly focused in Synthetic Biology.



Publications

1. S. Meyer, J. Chappell, S. Sankar, R Chew, J. B. Lucks* (2015). Improving fold activation of small transcription activating RNAs (STARs) with rational RNA engineering strategies. Biotechnology and Bioengineering. 36, 154-160.

2. J. Chappell, K. E. Watters, M. K. Takahashi, J. B. Lucks* (2015). A Renaissance in RNA Synthetic Biology: New Mechanisms, Applications and Tools for the Future. Current Opinion in Chemical Biology. 28, 47-56.

3. M. K. Takahashi, C. A. Hayes, J. Chappell, Z. Z. Sun, R. M. Murray, V. Noireaux, J. B. Lucks* (2015). Characterizing and Prototyping Genetic Networks with Cell-Free Transcription-Translation Reactions. Methods. Doi: 10.1016/j.ymeth.2015.05.020.

4. J. Chappell, M. K. Takahashi, J. B. Lucks* (2015). Creating Small Transcription Activating RNAs. Nature Chemical Biology, 11, 214-220.

5. M. K. Takahashi, J. Chappell, C. A. Hayes, Z. Z. Sun, J. Kim, V. Singhal, K. J. Spring, S. Al-Khabouri, C. P. Fall, V. Noireaux, R. M. Murray, J. B. Lucks* (2014). Rapidly characterizing the fast dynamics of RNA genetic circuitry with in vitro transcription-translation (TX-TL) reactions. ACS Synthetic Biology, 15, 503-515.

6. J. Chappell, M. K. Takahashi, S. Meyer, D. Loughrey, K. E. Watters, J. B. Lucks* (2013). The Centrality of RNA for Engineering Gene Expression. Biotechnology Journal, 8, 1379-1395.

7. J. Chappell, K. Jensen, P.S. Freemont* (2013). Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology. Nucleic Acids Research, 41, 3471-3481.

8. J. Chappell, P. S. Freemont* (2013). In Vivo and In Vitro Characterization of σ 70 Constitutive Promoters by Real-Time PCR and Fluorescent Measurements. Methods in Molecular Biology – Synthetic Biology, 61-74.

9. J. Chappell, P. S. Freemont* (2013). Synthetic biology – A new generation of biofilm biosensors

10. S. Gulati, V. Rouilly, X. Niu, J. Chappell, R. I. Kitney, J. B. Edel, P. S. Freemont and A. J. deMello (2009). Opportunities for microfluidic technologies in synthetic biology. Journal of The Royal Society Interface, 6, 493-506

Contact Details


James Chappell,
120 Olin Hall,
Chemical and Biomolecular Engineering
Cornell,
NY, USA

Email - jchappell105@gmail.com

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