|Analyzing pooled sequenced data with selection|| Main project page|
Simulating evolution and then pooled sequencing
We can use Dick Hudson's MsSel (MS with selection) to generate a SNP distribution.
In MsSel, we can specify an allele frequency trajectory for a site. We can generate a trajectory based on a simple W-F simulation with selection.
(1) draw a coverage (n) from Pois(λ) where
(2) fi (frequency of the ith SNP) ~