User:Holmesbr

Brad Holmes

Laboratory of Molecular Genetics
6 Center Drive
NICHD, NIH
Bethesda, MD 20892

(username) AT mail DOT nih DOT gov

Hi! My name is Brad Holmes and I am Robert Crouch's lab in the LMG. We study ribonuclease H1/I.

Research Interests

RNase H1
mtDNA replication

Education/Lab Experience

• B.S. in Biochemistry, Texas A&M University, 2004 Summa Cum Laude.
  • Worked as an undergraduate researcher for two years and then as a post-bac for Jerry Tsai, studying protein structure prediction and homology modeling.
• Summer Undergraduate Reserach Fellow at UT Southwestern Medical Center. Worked for 10 weeks for Kevin Gardner to implement a few software programs to automate the process of NMR data analysis.

Publications

1. Parsons J, Holmes JB, Rojas JM, Tsai J, and Strauss CE. Practical conversion from torsion space to Cartesian space for in silico protein synthesis. J Comput Chem. 2005 Jul 30;26(10):1063-8. DOI:10.1002/jcc.20237 |
1. Holmes JB and Tsai J. Characterizing conserved structural contacts by pair-wise relative contacts and relative packing groups. J Mol Biol. 2005 Dec 2;354(3):706-21. DOI:10.1016/j.jmb.2005.09.081 |
1. Fischer TB, Holmes JB, Miller IR, Parsons JR, Tung L, Hu JC, and Tsai J. Assessing methods for identifying pair-wise atomic contacts across binding interfaces. J Struct Biol. 2006 Feb;153(2):103-12. DOI:10.1016/j.jsb.2005.11.005 |
1. Holmes JB and Tsai J. Some fundamental aspects of building protein structures from fragment libraries. Protein Sci. 2004 Jun;13(6):1636-50. DOI:10.1110/ps.03494504 |

Pages Constructing

1. Immunocytochemistry
2. Holmesbr/plan