User:Tkadm30/Notebook/chim trills notebook/Research

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Research topics

Translocation and internalization of metallic nanoparticles

Review:

• Aluminium-induced neurotoxicity and chronic neuroinflammation in the microglia
• Translocation of PM2.5 to the brain.
• The Effects of Nanomaterials as Endocrine Disruptors.

Translocation of aluminium oxide in the microglia

• Glia activation induced by peripheral administration of aluminum oxide nanoparticles in rat brains

Nanotoxicity and genotoxicity of long-term PM2.5 exposure

• The immunological nanotoxicity and genotoxicity of fine/ultra-fine particulate matter (PM size < 2.5µm) is under investigation.
• The chemical clumping (aerosol aggregation) behavior of PM2.5 may require a ultrasonic atomization device.
• The synthetic nature and chemistry of PM2.5 may require further research.

Characterization of the Gulf War Syndrome (Unknown variant)

The phenotype of the Gulf War Syndrome (Unknown variant) is not well understood.

Epidemiological evidences of PM2.5-mediated damage to the neuroimmune system includes:

• Alteration of cytokines and ROS production
• Stress-induced neuroinflammation (GSK3, AKT, TLR4)[1][2]
• Mitochondrial DNA (mtDNA) oxidative stress (Aluminium oxide?, silica)
• Microglial activation markers? (MAC1, Glutaminase, TLR2, TLR4)[3]
• Decrease in neurotrophin expression (BDNF)
• Modulation of neuroendocrine response
• Alteration of miRNA expression (miR-15, miR-146a, miR-222, miR-337-5p)
• Glutamatergic NMDA dysregulation?
• TLR4-mediated psychosis?

Nanotoxicity of metal oxides:

• Aluminium oxide may induce proinflammatory cellular response and oxidative stress.

See also:

• The neuroendocrinology of chronic fatigue syndrome.
• Aluminium oxide nanoparticles induce mitochondrial-mediated oxidative stress and alter the expression of antioxidant enzymes in human mesenchymal stem cells.
• Limbic encephalitis
• Topic: Neurovascular and neuroinflammation mechanisms associated with bipolar disorder

Nanoparticle-based drug delivery systems

Translocation and internalization of NPs:

• Synthetic nucleic acid delivery systems
• Engineered nanoparticles can be developed to enter blood-brain barrier through intracellular (siRNA) delivery.
• Cellular internalization of quantum dots.

Aerosolized drug carriers:

• Photoactivated drug delivery vectors
• Condensation (Monodisperse?) aerosols
• Functionalized nanodiamonds (ND)
  • Diamond nanowire
• Calcium carbonate
• Gold nanoparticles (AuNP) (non-cytotoxic)
• Mesoporous silica nanoparticles
• Microfluidics (MEMS)

Research projects

Project SOUR DIESEL: Differential effects of PM2.5 exposure on the neuroimmune system and microglial cells

I aim to understand the nanotoxicity and genotoxicity of long-term PM2.5 and aerosolized nanoparticles exposure on physiological and neurological processes: In specific, I'm interested to understand the effects of PM2.5 exposure on chronic pulmonary diseases (COPD), miRNA expression (psychosis biomarker) and TLR4 signaling.

Research highlights:

• The differential effects of PM2.5 exposure on stress-induced neuroinflammation and microglial activation require further research.
• PM2.5-mediated TLR4 signaling is poorly understood/documented.

Research subtopics:

• Microglia/Brain
• Toll-like receptor 4/miRNA
• Drug delivery systems/Central nervous system
• Psychosis/Aggression
• Nanoparticles/MEMS
• Drug addiction/Opioids

Keywords: metal oxides, nanoparticles, microfluidics, bioaerosol, drug delivery, CNS, microglia, PM2.5, TLR4, stress-induced neuroinflammation

Project HONEY TRAP: Neuropsychology of modern cognitive warfare

Clandestine/solar geoengineering activity is a controversial issue. The aim of this research project is to understand how artificial intelligence is used to deter public disclosure on solar geoengineering.

Research subtopics:

• Neuropolitics/Artificial intelligence
• Ultrasonic neuromodulation/Brain-computer interfaces
• Human behavior/Psychology
• Psychocomputational energetics/Hypercomputation
• Alzheimer

External links:

• The social neuropolitics of climate change
• Project STREET WISE

Keywords: psychology, consciousness, science, deception, media blackout, cognitive dissonance, disinformation, cognitive infiltration, education, research, PM2.5, neuropolitics, neuromodulation, behavior, humans, cognition

References

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783243/

   Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior.

2. https://www.ncbi.nlm.nih.gov/pubmed/24680857

   The role of TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in hippocampal neurons.

3. https://www.ncbi.nlm.nih.gov/pubmed/19406832

   Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter.

4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762128/

   Autoimmune limbic encephalitis presenting as relapsing psychosis.

5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309507/

   Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype.

6. http://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-014-0075-z

   Nanodiamonds act as Trojan horse for intracellular delivery of metal ions to trigger cytotoxicity.

7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853215/

   Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia.

8. https://www.ncbi.nlm.nih.gov/pubmed/20439179

   Silica-based nanoparticle uptake and cellular response by primary microglia.

See also

• Photographic evidences Notebook
• MicroRNA Notebook
• TLR Notebook