User:Tkadm30/Notebook/Brainstorming: Difference between revisions

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=== Subtopics ===
* Orthogonal and potentially harmful drug delivery evidences involving unidentified chemical inducers and repeated exposure may be light-sensitive and activated with light-gated photoreceptors.  
 
==== Orthogonal and potentially harmful drug delivery evidences involving unidentified chemical inducers and repeated exposure may be light-sensitive and activated with light-gated photoreceptors. ====
 
Notes (MAP/EGFR kinase related):
* Important secondary messengers: NMDA, Dopamine, Serotonin, GABA, '''AChr''', calmodulin, p38 MAP kinase  
* Important secondary messengers: NMDA, Dopamine, Serotonin, GABA, '''AChr''', calmodulin, p38 MAP kinase  
* [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Chemtrails911_notebook/Agent%20Buzz Agent Buzz] (Agent 15)
* [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Chemtrails911_notebook/BCTP BCTP]
Mitogen-Activated Protein Kinase:
* Sites of interests: p38 (MEK), EGFR (Fyn), c-Src homolog domain (brain/hippocampus/amygdala), Ras/Raf/MEK pathway (Bcl-2), NMDAR, NRG1
* Sites of interests: p38 (MEK), EGFR (Fyn), c-Src homolog domain (brain/hippocampus/amygdala), Ras/Raf/MEK pathway (Bcl-2), NMDAR, NRG1
* Long term effects of experimental chemical promoter/repressor Z on cell division and duplication ?  
* Long term effects of experimental chemical promoter/repressor Z on cell division and duplication ?  
 
* Cannabinoid agonists and the cholinergic system: Selective affinity for the mAChR receptor may indicates endogenous endocannabinoids as potential agents for neuroprotection agaisn't benzylic-derived nerve gas precursors and Alzheimer disease. (EC 3.1.1.8)  
==== Cannabinoid agonists and the cholinergic system: Selective affinity for the mAChR receptor may indicates endogenous endocannabinoids as potential agents for neuroprotection agaisn't benzylic-derived nerve gas precursors and Alzheimer disease. (EC 3.1.1.8) ====
* '''Delta(9)-THC'''  mediated neurotransmitter synthesis: Hippocampus/Amygdala b-amyloid cleaving ? (GABA intermediate messenger/mAChR link..?) ?
* Key roles for nanoparticles based chemical inducers and repressors are multiples and under intense research including but not limited to chemotherapy and bioinformatics.
* Key roles for nanoparticles based chemical inducers and repressors are multiples and under intense research including but not limited to chemotherapy and bioinformatics.
 
* How the chemtrails program may have subverted the general public is an evidence of deeper conspiracy to allow unrestricted chemical spraying over domestic populations: '''Quebec government failure to protect and inform its citizens may suggests Quebec competing interests for experimental biopharmacological applications over public health and the well-being of its population.'''
==== How the chemtrails program may have subverted the general public is an evidence of deeper conspiracy to allow unrestricted chemical spraying over domestic populations: Quebec government failure to protect and inform its citizens may suggests Quebec competing interests for experimental biopharmacological applications over public health and the well-being of its population. ====
* The photoreceptor component of Agent E. coli may be closely associated to the mAChr receptor, a neurotransmitter with high-affinity for acetylcholinesterase inhibition found in many toxic [[User:Etienne_Robillard/Notebook/Agent_BZ|nerve agents]] used for chemical warfare, which are blocking the mAchr receptor to phosphorylate, thus '''producing plaques of b-amyloids toxic aggregates''' in the hippocampus and amygdala regions, short-circuiting your consciousness to express feelings and emotions apart when asking you to resolve 2+2=5.
 
* The use of benzilic-like reagents (benzaldehyde, benzoic acid) and 1 2-cyanoethyl positive anion (acetonitrile, trichloroisocyanuric acid, isocyanides) are in addition believed to be employed as organocatalysts (phosphotransferase) to increase the effectiveness of the administred compound or drug, believed to be composed of at least 1 chlorinated anion bound to a disubstituted [[User:Etienne_Robillard/Notebook/Schiff_base|Schiff base]] (-rC=N).
Thanks for reading this far. This topic may be a little broad and require some refactoring.
 
Goal(s): xxx
 
Genes/protein:
* [[/EGFR|Epidermal Growth Factor Receptor (Protein)]]: A key membrane for targeted drug delivery, chemotherapy and perhaps tyrosine kinase protein blocking in '''MAJOR GROUPS''' of '''HUMANS populations''' possessing the '''EGF''' gene...
* [[/CYP3A4|CYP3A4 (Protein-coding gene)]]
 
Cancer therapy drugs :
* [[/Paclitaxel|Paclitaxel (Drug)]]:  Compare this with doxorubicin; non EGF(R)-specific (?);
* [[/Docetaxel|Docetaxel (Drug)]]: A generic paclitaxel molecule used for targeted cancer therapy; Can be combined with Doxorubicin for advanced chemotherapy uses.  
** Thus is Docetaxel classifiable as a DNA Topoisomerase II inhibitor drug '''regulating''' cell-dependent mitosis?
* [[/Doxorubicin|Doxorubicin (Drug)]]: A anti-malaria (?) drug with EGF(R)-specific binding;
* [[/Imatinib (Drug)]]: A tyrosine kinase inhibitor drug designed by Novartis. Like Doxorubicin, may produces side effects including skin rashes and headaches. In addition, may also inhibit aCh(R) (acetylcholinesterase) and modulate ATP (adenosine tryphosphate) synthase inside the mitochondria membrane, suggesting Imatinib could have a potential role in regulating neurotransmitter regulation (calmodulin, GABA, etc). However it is unknown at this time if a generic version of this drug could deliver ATP mediated energy payload to epithelial cells from EGFR over-expressed phospholipid (ie: cholesterol). A suggested hypothesis is thus to assert the drug delivery factors of aCh derived receptors associated specifically to EGFR binding site in Alzheimer disease and related ATP based ligands. [Keywords: Imatinib, Alzheimer, ATP, Brain, aChr, calmodulin, EGFR, breast cancer, GABA, Glutamate, Glycine, Tyrosine, Adenosine, NMDA, Serotonin, [http://www.sciencedaily.com/releases/2007/12/071203190607.htm Liposome]]
 
==== Predicting the role of competent cells in irreversible morphogenesis of highly pathogenic Anthrax strain: Science-fiction or red heering? ====
 
In other words, has "Synthia" been invited by fanatics to participate in a organized molecular hijack of the MAP kinase pathway
to produce high-quality Anthrax spores ?
 
Therefore to confirm "Synthia" as a prime suspect in this organized murdering scheme, understanding the regulation of the MAP kinase protein
is fundamental to hypothesize the role and implications of competent cells in Anthrax [http://academic.brooklyn.cuny.edu/biology/bio4fv/page/endocyta.htm endocytosis]. [http://www.ks.uiuc.edu/Research/anthrax/ 1]
 
===== So, is the aerosol agent a gold standard in '''restriction endonucleases based''' recombinant vaccine? =====
 
"Battelle, as a CIA contractor, partnered with Bioport for America's sole anthrax vaccine production. Bioport-largely owned by Britain's top secret biowarfare consortium PortonDown, '''bin Laden family associate [http://investors.emergentbiosolutions.com/phoenix.zhtml?c=202582&p=irol-govBio&ID=158319 Faud El Hibri]''', Admiral William J. Crowe, Jr., a former Chairman of the Joint Chiefs of Staff, and others (including, according to some investigators, the multinational investment firm and defense contractor, the Carlyle Management Group, that managed bin Laden family millions prior to 9-11, directed by past CIA director Frank Carlucci, James Baker III (->), and Past President George H.W. Bush);" [http://www.911review.org/Sept11Wiki/Battelle.shtml 2]
 
===== Okay! So where is Scooby Doo now, Mr. triple Dealer Spy ? =====
 
"For instance, Hatfill allegedly said that anyone who knew "how to grow anthrax spores of one to '''three microns''' had to know that the hole in an envelope is '''10 microns''' and that the spores would escape." [http://cryptome.org/is-z-hatfill.htm 3]
 
 
 
 
[[Category: CanadaInDistressCategory DeathOfEvidenceCategory]]

Revision as of 09:44, 16 December 2014

  • Orthogonal and potentially harmful drug delivery evidences involving unidentified chemical inducers and repeated exposure may be light-sensitive and activated with light-gated photoreceptors.
  • Important secondary messengers: NMDA, Dopamine, Serotonin, GABA, AChr, calmodulin, p38 MAP kinase
  • Sites of interests: p38 (MEK), EGFR (Fyn), c-Src homolog domain (brain/hippocampus/amygdala), Ras/Raf/MEK pathway (Bcl-2), NMDAR, NRG1
  • Long term effects of experimental chemical promoter/repressor Z on cell division and duplication ?
  • Cannabinoid agonists and the cholinergic system: Selective affinity for the mAChR receptor may indicates endogenous endocannabinoids as potential agents for neuroprotection agaisn't benzylic-derived nerve gas precursors and Alzheimer disease. (EC 3.1.1.8)
  • Key roles for nanoparticles based chemical inducers and repressors are multiples and under intense research including but not limited to chemotherapy and bioinformatics.
  • How the chemtrails program may have subverted the general public is an evidence of deeper conspiracy to allow unrestricted chemical spraying over domestic populations: Quebec government failure to protect and inform its citizens may suggests Quebec competing interests for experimental biopharmacological applications over public health and the well-being of its population.
  • The photoreceptor component of Agent E. coli may be closely associated to the mAChr receptor, a neurotransmitter with high-affinity for acetylcholinesterase inhibition found in many toxic nerve agents used for chemical warfare, which are blocking the mAchr receptor to phosphorylate, thus producing plaques of b-amyloids toxic aggregates in the hippocampus and amygdala regions, short-circuiting your consciousness to express feelings and emotions apart when asking you to resolve 2+2=5.
  • The use of benzilic-like reagents (benzaldehyde, benzoic acid) and 1 2-cyanoethyl positive anion (acetonitrile, trichloroisocyanuric acid, isocyanides) are in addition believed to be employed as organocatalysts (phosphotransferase) to increase the effectiveness of the administred compound or drug, believed to be composed of at least 1 chlorinated anion bound to a disubstituted Schiff base (-rC=N).
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