Asymmetric and unconventional gene therapy trials on unwary citizens is scientifically irresponsible
Genes/protein:
Epidermal Growth Factor Receptor (Protein): A key membrane for targeted drug delivery, chemotherapy and perhaps tyrosine kinase protein blocking in MAJOR GROUPS of HUMANS populations possessing the EGF gene...
Paclitaxel (Drug): Compare this with doxorubicin; non EGF(R)-specific (?);
Docetaxel (Drug): A generic paclitaxel molecule used for targeted cancer therapy; Can be combined with Doxorubicin for advanced chemotherapy uses.
Thus is Docetaxel classifiable as a DNA Topoisomerase II inhibitor drug regulating cell-dependent mitosis?
Doxorubicin (Drug): A anti-malaria (?) drug with EGF(R)-specific binding;
/Imatinib (Drug): A tyrosine kinase inhibitor drug designed by Novartis. Like Doxorubicin, may produces side effects including skin rashes and headaches. In addition, may also inhibit aCh(R) (acetylcholinesterase) and modulate ATP (adenosine tryphosphate) synthase inside the mitochondria membrane, suggesting Imatinib could have a potential role in regulating neurotransmitter regulation (calmodulin, GABA, etc). However it is unknown at this time if a generic version of this drug could deliver ATP mediated energy payload to epithelial cells from EGFR over-expressed phospholipid (ie: cholesterol). A suggested hypothesis is thus to assert the drug delivery factors of aCh derived receptors associated specifically to EGFR binding site in Alzheimer disease and related ATP based ligands. [Keywords: Imatinib, Alzheimer, ATP, Brain, aChr, calmodulin, EGFR, breast cancer, GABA, Glutamate, Glycine, Tyrosine, Adenosine, NMDA, Serotonin, Liposome]
Recombinant B. anthracis (endo)spores serving as potential biological agent to deter anthrax and influenza microbes in murrine and swine, or the emergence of nanovaccines in orthogonal drug delivery systems, with potential immunogenic features, like calmodulin (CaM) protein expression, and site-specific antigenic-like response (mutagenesis):
http://anthraxvaccine.org (currently out-of-service! Last updated: 2012/03/30. Why is the downtime not resolved??)
Keywords: anthrax vaccine, BCTP, B. anthracis, B. cereus, food-grade protein nanoemulsions based drug delivery systems in aerosolized form, nanovaccines, H1N1, cytokine, bioaerosols, antigenic sin, antigenic drift, antigenic shift, immunotoxins, rPA (recombinant Protective Antigen),
Recombinant H5N1 pandemic flu antigen: Is the repeated exposure to the nanoemulsion-based reagent can induces a immunogenic response mediated by tolerogenic dentritic cells activation, thus preventing hemagluttinin mutagenesis? Answer: The truth is in PMC2977862...
Liposome-mediated Dentritic Cells transfection: an orthogonal pathway for (inter-species) gene transfer and drug metabolism using hemogenic proteins (peptides) macrophages? (aka cytokines)
Keywords: Google: "transfection epithelial cells"
Liposome for Drug Delivery!
Quotes
"During times of universal deceit, telling the truth becomes a revolutionary act." -- George Orwell (1984)
"We have now sunk to a depth at which restatement of the obvious is the first duty of intelligent men." -- George Orwell
"We shall defend our island, whatever the cost may be, we shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the fields and in the streets, we shall fight in the hills; we shall never surrender." -- Winston Churchill
"It is no use saying, 'We are doing our best.' You have got to succeed in doing what is necessary." -- Winston Churchill
"You have enemies? Good. That means you've stood up for something, sometime in your life." -- Winston Churchill
"What kind of people do they think we are? Is it possible they do not realize that we shall never cease to persevere against them until they have been taught a lesson which they and the world will never forget?" -- Winston Churchill
The following clip provides good insights on ultrasonic dispersion of most likely silicon-based nanoparticles (liposomes) for pharmaceutical grade drug delivery: http://www.youtube.com/embed/Ac2s_fiTl0E
Etienne Robillard 07:18, 5 May 2012 (EDT): Whoa, calmodulin mediated signal transduction using fat-soluble nanoparticles aggregating to tumor cells in a "controlled/directed" process using heat/light energy as the master switch for tyrosine kinase II to induce or inhibit (auto)phosphorylation of pTyr residues?
