User:Tkadm30/Notebook/chim trills notebook: Difference between revisions
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== Hypothesis == | == Hypothesis == | ||
The biological | 1. The biological impacts of aerosolized nanoparticles (ANP) are poorly understood. | ||
2. The cytotoxicity of nanoparticle-based stratospheric aerosol injection on human health requires further investigations. | |||
3. The differential effects of highly dispersed aerosols (HDA) on the neuroimmune system, lung function, chronic inflammation, and Alzheimer pathogenesis requires additional research. <cite>Gilmour-2004</cite> | |||
4. Microglial activation is implicated in the aluminium-induced neurotoxicity of aerosolized nanoparticles. | |||
== Differential effects of aerosolized nanoparticles == | |||
=== Cardiovascular system === | === Cardiovascular system === | ||
* Effects of particulate matter ( | * Effects of particulate matter (PM2.5) air pollution on cardiovascular disease <cite>Brook-2010</cite> | ||
** Increase in blood pressure <cite>Balasubramanian-2013</cite> | |||
=== Central nervous system === | |||
* Alzheimer disease <cite>Jung-2015</cite><cite>Levesque-2013</cite> | |||
* Parkinson disease <cite>Levesque-2013</cite> | |||
* PM2.5 exposure may cause chronic neuroinflammation and oxidative stress. <cite>Lei-2015</cite><cite>Liu-2015</cite><cite>Riva-2011</cite><cite>Levesque-2011</cite> | |||
* PM2.5 exposure may induce selective neurotoxicity through glutamatergic signaling and increase NMDA-induced excitotoxicity. <cite>Liu-2015</cite><cite>Morgan-2011</cite> | |||
* Cyclooxygenase-2, interleukin-1beta, and CD14 signaling upregulation. <cite>Solt-2008</cite> | |||
* Microglia-mediated dopaminergic neurotoxicity (Reactive microgliosis). <cite>Levesque-2013</cite> | |||
=== Endocrine system === | |||
* Decrease of serum testosterone levels <cite>Lavicoli-2013</cite> | |||
* Increase of serum estradiol levels <cite>Lavicoli-2013</cite> | |||
=== Lymphatic system === | |||
* Lipid peroxidation and oxidative DNA damage. <cite>Ambroz-2016</cite> | |||
=== Respiratory system === | |||
* AECOPD <cite>Lei-2015</cite> | * AECOPD <cite>Lei-2015</cite> | ||
* Lung cancer <cite>Hamra-2014</cite> | |||
* | |||
== Cognitive infiltration evidences == | == Cognitive infiltration evidences == | ||
* Facebook Deception: [[User:Etienne_Robillard/Notebook/chim_trills_notebook/2014/12/14|Notebook]] | * Facebook Deception: [[User:Etienne_Robillard/Notebook/chim_trills_notebook/2014/12/14|Notebook]] | ||
== Notes == | == Notes == | ||
* [http://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?] | * Aerosolized nanoparticles: | ||
** [http://www.energy.psu.edu/sites/default/files/files/JetFuels.pdf Advanced Thermally Stable Jet Fuels] | |||
** [http://www.energy.psu.edu/sites/default/files/files/coalbased_jetfuel.pdf The Coal-Based Jet Fuel Program] | |||
** [http://web.stanford.edu/group/pitsch/publication/ColketJet_Fuel_Surrogate_AIAA_2007.pdf Jet Fuel Surrogate Research] | |||
** [https://dspace.mit.edu/handle/1721.1/9116 Catalytic combustion of methane with nanostructured barium hexaaluminate-based materials] | |||
* Discussion: | |||
** [http://www.thenakedscientists.com/forum/index.php?topic=68004 Do coal-based jet fuel (JP-900) emit ultrafine particles?] | |||
** [http://www.thenakedscientists.com/forum/index.php?topic=67942 Is coal fly ash a synthetic compound?] | |||
** [http://www.thenakedscientists.com/forum/index.php?topic=67302 Should we ban geoengineering?] | |||
** [http://www.thenakedscientists.com/forum/index.php?topic=68061 What is the Gulf War syndrome?] | |||
** [http://www.thenakedscientists.com/forum/index.php?topic=68101 What is a jet fuel surrogate?] | |||
* Documentation: | |||
** [https://en.wikipedia.org/wiki/Dodecane Dodecane (Wikipedia)] | |||
** [https://en.wikipedia.org/wiki/Ethylbenzene Ethylbenzene (Wikipedia)] | |||
** [http://www.ncbi.nlm.nih.gov/gene/2744 Glutaminase] | |||
** [http://www.ncbi.nlm.nih.gov/pubmed/?term=gulf+war+syndrome Gulf War syndrome (PubMed search)] | |||
** [https://en.wikipedia.org/wiki/Gulf_War_syndrome Gulf War syndrome (Wikipedia)] | |||
** [https://en.wikipedia.org/wiki/Methylcyclohexane Methylcyclohexane (Wikipedia)] | |||
== Resources == | == Resources == | ||
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== Keywords == | == Keywords == | ||
aerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, aerosolized jet fuel, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium hexaaluminate | |||
== Support this project == | |||
This project is entirely financed by personal donations. To support this project, use the following link | |||
to donate money via Paypal: https://paypal.me/EtienneRobillard | |||
== References == | == References == | ||
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#Herndon-2015 http://www.mdpi.com/1660-4601/12/8/9375/htm | #Herndon-2015 http://www.mdpi.com/1660-4601/12/8/9375/htm | ||
//Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health | //Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health | ||
#Herndon-2016 | #Herndon-2016 http://nuclearplanet.com/frontiers1.pdf | ||
//Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification. | //Human and Environmental Dangers Posed by Ongoing Global Tropospheric Aerosolized Particulates for Weather Modification. | ||
#Gilmour-2004 pmid=15061611 | #Gilmour-2004 pmid=15061611 | ||
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#Liu-2015 pmid=25913161 | #Liu-2015 pmid=25913161 | ||
//Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation. | //Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation. | ||
#Riva-2011 pmid=21506876 | |||
//Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice. | |||
#Levesque-2011 pmid=21561831 | |||
//Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. | |||
#Morgan-2011 pmid=21724521 | |||
//Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. | |||
#Cheng-2010 http://www.tandfonline.com/doi/abs/10.1080/027868201753306714 | |||
//Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels. | |||
#Ambroz-2016 pmid=27321041 | |||
//Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. | |||
#Balasubramanian-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402685/ | |||
//Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats. | |||
#Lavicoli-2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759935/ | |||
//The Effects of Nanomaterials as Endocrine Disruptors. | |||
#Solt-2008 pmid=18349428 | |||
//Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. | |||
#Levesque-2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660420/ | |||
//The Role of MAC1 in Diesel Exhaust Particle-induced Microglial Activation and Loss of Dopaminergic Neuron Function | |||
</biblio> | </biblio> | ||
Revision as of 11:04, 1 October 2016
Work-in-progress. Please correct any errors found.
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Hypothesis1. The biological impacts of aerosolized nanoparticles (ANP) are poorly understood. 2. The cytotoxicity of nanoparticle-based stratospheric aerosol injection on human health requires further investigations. 3. The differential effects of highly dispersed aerosols (HDA) on the neuroimmune system, lung function, chronic inflammation, and Alzheimer pathogenesis requires additional research. [1] 4. Microglial activation is implicated in the aluminium-induced neurotoxicity of aerosolized nanoparticles. Differential effects of aerosolized nanoparticlesCardiovascular system
Central nervous system
Endocrine systemLymphatic system
Respiratory systemCognitive infiltration evidences
Notes
ResourcesKeywordsaerosol, bioaerosol, nanoparticles, aluminium oxide, particulate matter, PM2.5, aerosolized jet fuel, gulf war syndrome, chronic neuroinflammation, vapor phase oxidation, hydrocarbons, barium hexaaluminate Support this projectThis project is entirely financed by personal donations. To support this project, use the following link to donate money via Paypal: https://paypal.me/EtienneRobillard References
LicenseCopyright (C) 2012-2016 Etienne Robillard Permission is granted to copy, distribute and/or modify this document Under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License".
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