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| __TOC__
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| Hello and welcome to my chemtrails notebook. :)
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| == Categories ==
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| === Challenges and goals ===
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| * Identify the bioaerosol(s) chemical origins and their chronic exposure effects on human health.
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| * Elucidate the synthetic origins of the '''[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788525/ ENGINEERED AEROSOLS]'''.
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| * [XXX Other challenges/goals here..]
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| === Introduction ===
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| TODO
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| === Subtopics ===
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| ==== Orthogonal and potentially harmful drug delivery evidences involving undisclosed bioaerosol exposure ====
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| Start here if you wish to help:
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| * [http://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Chemtrails911_notebook/BCTP BCTP]: Unit 1: Bicomponent Triton X-100 Tri-n-butyl phosphate
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| ** Unit 1.1: Oil-in-water nanoemulsions as orthogonal drug delivery systems:
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| *** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065798/ Food protein-stabilized nanoemulsions as potential delivery systems for poorly water-soluble drugs: preparation, in vitro characterization, and pharmacokinetics in rats.]
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| ==== Asymmetric and unconventional gene therapy trials on unwary citizens is scientifically irresponsible ====
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| Genes/protein:
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| * [[/EGFR|Epidermal Growth Factor Receptor (Protein)]]: A key membrane for targeted drug delivery, chemotherapy and perhaps tyrosine kinase protein blocking in '''MAJOR GROUPS''' of '''HUMANS populations''' possessing the '''EGF''' gene...
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| * [[/CYP3A4|CYP3A4 (Protein-coding gene)]]
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| Cancer therapy drugs :
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| * [[/Paclitaxel|Paclitaxel (Drug)]]: Compare this with doxorubicin; non EGF(R)-specific (?);
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| * [[/Docetaxel|Docetaxel (Drug)]]: A generic paclitaxel molecule used for targeted cancer therapy; Can be combined with Doxorubicin for advanced chemotherapy uses.
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| ** Thus is Docetaxel classifiable as a DNA Topoisomerase II inhibitor drug '''regulating''' cell-dependent mitosis?
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| * [[/Doxorubicin|Doxorubicin (Drug)]]: A anti-malaria (?) drug with EGF(R)-specific binding;
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| * [[/Imatinib (Drug)]]: A tyrosine kinase inhibitor drug designed by Novartis. Like Doxorubicin, may produces side effects including skin rashes and headaches. In addition, may also inhibit aCh(R) (acetylcholinesterase) and modulate ATP (adenosine tryphosphate) synthase inside the mitochondria membrane, suggesting Imatinib could have a potential role in regulating neurotransmitter regulation (calmodulin, GABA, etc). However it is unknown at this time if a generic version of this drug could deliver ATP mediated energy payload to epithelial cells from EGFR over-expressed phospholipid (ie: cholesterol). A suggested hypothesis is thus to assert the drug delivery factors of aCh derived receptors associated specifically to EGFR binding site in Alzheimer disease and related ATP based ligands. [Keywords: Imatinib, Alzheimer, ATP, Brain, aChr, calmodulin, EGFR, breast cancer, GABA, Glutamate, Glycine, Tyrosine, Adenosine, NMDA, Serotonin, [http://www.sciencedaily.com/releases/2007/12/071203190607.htm Liposome]]
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| See also:
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| * [[http://www.chemocare.com/whatis/types_of_chemotherapy.asp Types of Chemotherapy]]
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| * [[http://en.wikipedia.org/wiki/Topoisomerase Topoisomerase]] (wikipedia)
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| ==== Case-studies ====
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| H1N1 flu stuff, by year and relevance of publication. (Unit 3)
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| * [http://www.ncbi.nlm.nih.gov/pubmed/20962084 Modifications in the polymerase genes of a swine-like triple-reassortant influenza virus to generate live attenuated vaccines against 2009 pandemic H1N1 viruses.]
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| * [http://www.ncbi.nlm.nih.gov/pubmed/20965669 Potential role of viral surface glycoproteins in the replication of H3N2 triple reassortant influenza A viruses in swine and turkeys.]
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| * [http://www.ncbi.nlm.nih.gov/pubmed/22090121 Highly pathogenic avian influenza virus subtype H5N1 escaping neutralization: more than HA variation.]
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| * Recombinant ''B. anthracis'' (endo)spores serving as potential biological agent to deter anthrax and influenza microbes in murrine and swine, or the emergence of nanovaccines in '''orthogonal drug delivery systems''', with potential immunogenic features, like calmodulin (CaM) protein expression, and site-specific antigenic-like response (mutagenesis):
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| ** http://anthraxvaccine.org (currently out-of-service! Last updated: 2012/03/30. Why is the downtime not resolved??)
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| ** Also look [http://www.pennlive.com/midstate/index.ssf/2012/03/pennsylvania_flu_cases_drop_by.html here] for more dots. And [http://anthraxvaccine.blogspot.com/ here] too.
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| ** Keywords: anthrax vaccine, BCTP, ''B. anthracis'', ''B. cereus'', food-grade protein nanoemulsions based drug delivery systems in aerosolized form, nanovaccines, H1N1, cytokine, bioaerosols, antigenic sin, antigenic drift, antigenic shift, immunotoxins, rPA (recombinant '''P'''rotective '''A'''ntigen),
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| ** [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742988/ A single immunization with a '''dry powder''' anthrax vaccine protects rabbits against lethal aerosol challenge.]
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| ** 19514852 (pXO1 = conjugative plasmid, 184 kb long)
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| ** [http://www.uniprot.org/uniprot/P13423 Protective antigen precursor - Bacillus Anthracis]
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| * Recombinant H5N1 pandemic flu antigen: Is the repeated exposure to the nanoemulsion-based reagent can induces a immunogenic response mediated by tolerogenic '''dentritic cells''' activation, thus preventing hemagluttinin mutagenesis? Answer: The truth is in [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977862 PMC2977862]...
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| ** '''Liposome-mediated Dentritic Cells transfection: an orthogonal pathway for (inter-species) gene transfer and drug metabolism using hemogenic proteins (peptides) macrophages? (aka cytokines)'''
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| *** Keywords: Google: "transfection epithelial cells"
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| [[Image: Liposome.jpg|300px|right|Liposome for Drug Delivery!]]
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| [[Category: CanadaInDistressCategory]]
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| == Quotes ==
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| * "During times of universal deceit, telling the truth becomes a revolutionary act." -- George Orwell (1984)
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| * "We have now sunk to a depth at which restatement of the obvious is the first duty of intelligent men." -- George Orwell
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| * "We shall defend our island, whatever the cost may be, we shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the fields and in the streets, we shall fight in the hills; we shall never surrender." -- Winston Churchill
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| * "It is no use saying, 'We are doing our best.' You have got to succeed in doing what is necessary." -- Winston Churchill
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| * "You have enemies? Good. That means you've stood up for something, sometime in your life." -- Winston Churchill
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| * "What kind of people do they think we are? Is it possible they do not realize that we shall never cease to persevere against them until they have been taught a lesson which they and the world will never forget?" -- Winston Churchill
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| * [http://openwetware.org/images/6/66/Science_in_the_city_2-02.png "All free men, wherever they may live, are citizens of Berlin. And therefore, as a free man, I take pride in the words "Ich bin ein Berliner!" -- John F. Kennedy]
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| == Multimedia ==
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| * BattellePharma intro movie: http://www.youtube.com/embed/VC5vG_nO0Gk
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| * The following clip provides good insights on ultrasonic dispersion of most likely silicon-based nanoparticles (liposomes) for pharmaceutical grade drug delivery: http://www.youtube.com/embed/Ac2s_fiTl0E
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| == See also ==
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| Biology:
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| * [http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/otherendo/pineal.html Pineal Gland and Melatonin]
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| * [http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch08/ch8-8.html Solvents Effects]
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| * [http://www.medwelljournals.com/fulltext/?doi=javaa.2011.1895.1900 Modes of Action of Probiotics: Recent Developments]
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| * Amino acids:
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| ** [http://faculty.ccbcmd.edu/courses/bio141/lecguide/unit4/antigens/antigens.html The Adaptive Immune System: Antigens]
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| ** [http://www.biology.arizona.edu/biochemistry/problem_sets/aa/aa.html The Chemistry of Amino Acids]
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| ** [http://toxsci.oxfordjournals.org/content/76/1/131/F1.large.jpg Fatty Acid Amide Hydrolase]
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| * Genetic acquisitions of synthetic like antigens (ie: vaccine escape evidences)
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| ** [http://pf11.blogspot.com/2010/03/zoonotic-h9n2-avian-influenza-further.html "The truth is in the sequences."]
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| ** [http://www.lewrockwell.com/sardi/sardi133.html Why Isn't the H1N1 Pandemic Flu Being Investigated as a Designed Bioweapon?]
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| ** [http://anthro.palomar.edu/mendel/mendel_3.htm Basic Principles of Genetics: Exceptions to Simple Inheritance] (non-Mendelian inheritance)
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| ** [http://www.mendeley.com/research/highly-pathogenic-avian-influenza-virus-h5n1-egypt-escapes-vaccineinduced-immunity-confers-clinical-protection-against-heterologous-clade-22-1-egyptian-isolate/ Highly pathogenic avian influenza virus H5N1 from Egypt escapes vaccine-induced immunity but confers clinical protection against a heterologous clade 2.2.1 Egyptian isolate.]
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| Peoples:
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| * [http://keith.seas.harvard.edu/FICER.html Fund for Innovative Climate and Energy Research]
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| * [http://caseclosedbylewweinstein.wordpress.com/2009/06/28/tracking-dr-ivins%E2%80%99-rmr-1029-anthrax-more-questions-for-um-and-lsu-researchers/ tracking Dr. Ivins’ RMR-1029 anthrax; more questions for UM and LSU researchers]
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| * [http://cns.miis.edu/wmdjunction/110822_fbi_anthrax.htm New Questions About the FBI's Anthrax Case: Valid Concerns or Red Herring?]
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| * [http://usasurvival.org/ck03.25.10.html Obama Obstructs Oversight of FBI in Anthrax Case]
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| * [http://killerspray.com/blog?post=Teen_SofiaXenidis_call2_action Sofia Xenidis Testimonial and Call for Actions]
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| Wikipedia:
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| * [http://en.wikiversity.org/wiki/Introduction_to_psychology/Consciousness Introduction to psychology: Consciousness]
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| News and media coverage:
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| * [http://www.nature.com/news/remote-controlled-genes-trigger-insulin-production-1.10585 Remote-controlled genes trigger insulin production]
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| ** [[User:Etienne Robillard|Etienne Robillard]] 07:18, 5 May 2012 (EDT): Whoa, calmodulin mediated signal transduction using fat-soluble nanoparticles aggregating to tumor cells in a "controlled/directed" process using heat/light energy as the master switch for tyrosine kinase II to induce or inhibit (auto)phosphorylation of pTyr residues?
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| * [http://www.naturalnews.com/034906_Bill_Gates_geo-engineering_chemtrails.html Bill Gates exposed for funding research, promotion of spraying geo-engineered 'chemtrails' across globe], 2012/02/08
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| * [http://www.crainsdetroit.com/article/20110803/FREE/110809957 NanoBio gets license from agency to develop vaccine to fight respiratory syncytial virus infections], 2011/08/03
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| * [http://www.sciencedaily.com/releases/2010/09/100930142727.htm, Microbes Engineered for Low-Cost Production of '''Anti-Cancer''' Drug, Taxol], 2010
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| * [http://www.azonano.com/news.aspx?newsID=15165 GSK and NanoBio Signs Exclusive Over-the-Counter Licensing Agreement for Nanoemulsion Treatment], 2009/12/16
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| * [http://www.schizophreniaforum.org/new/detail.asp?id=1413 Does Oxidative Stress Link NMDA and GABA Hypotheses of Schizophrenia?] ([http://www.sciencedirect.com/science/article/pii/S0304394008010197 Study]), 2007/12/09
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| * [http://phys.org/news7764.html Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates], 2005/11/01
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| * [http://www.thefreelibrary.com/BattellePharma+to+Present+At+Respiratory+Drug+Delivery+VIII...-a085494227 BattellePharma to Present At Respiratory Drug Delivery VIII Conference.], 2002/05/07
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| * [http://www.nytimes.com/2001/09/04/world/us-germ-warfare-research-pushes-treaty-limits.html U.S. Germ Warfare Research Pushes Treaty Limits], 2001/09/04
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