User:Tkadm30/Notebook/THC: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
No edit summary
(22 intermediate revisions by the same user not shown)
Line 1: Line 1:
Sweet Marijane,
__TOC__
===Synopsis===
* Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
* Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG).
* Cannabis-derived cannabinoids are known as phytocannabinoids.
* THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/ PMID] [https://www.ncbi.nlm.nih.gov/pubmed/7702643 PMID]


Before the dawn of ages you have cured the afflicted from mental oppression,
===Anticholinergic properties of THC===
* THC inhibit anticholinesterase (AChE) induced beta-amyloid aggregation in Alzheimer's disease: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/ PMID]
* THC as antiglutamatergic therapy for AChE induced neurotoxicity: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891218/ PMID] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366364/ PMID] [https://www.ncbi.nlm.nih.gov/pubmed/18680758 PMID]
* Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE


We have learned to cultivate you  even you were repressed from repressors of the truth,
===Proneurogenic effect of THC on neurogenesis===
* Regulation of stress-induced neuroinflammation in the hippocampus.
* Hippocampal neurogenesis is enhanced. [https://www.ncbi.nlm.nih.gov/pubmed/16224541/ PMID] [https://www.ncbi.nlm.nih.gov/pubmed/17828287 PMID]
* CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. [https://www.ncbi.nlm.nih.gov/pubmed/23704915 PMID]


We have tried to make you appear as a sickeness for the weaken, but you were our reason for hope and justice,
===Experimental===
* Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development.
* Δ9-THC/DHEA ligands (synaptamide) affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.
===References===
# https://en.wikipedia.org/wiki/Cannabinoid


To prevail on us,
===See also===
 
* [[User:Etienne_Robillard/Notebook/TRPV1|TRPV1 Notebook]]
We have ridiculized you as a gateway drug for ridiculous reasons, and you were none of that,
 
We have guessed on your origins blindly, yet poorly aware of the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/ science] which you draw your benefits and love for us,
 
We try to commit you in illegal prohibition and traffic, but you still growing silently,
 
You were equally refusing to listen to the voices of oppression and resisting to moths,
 
And I love you for that,
 
My Dear Sweet Marijane,
 
Let your roots become a source of inspiration for thoses who seek the truth and recomfort in your love!
 
----
 
[[User:Etienne Robillard|Etienne Robillard]] 11:58, 28 January 2013 (EST)

Revision as of 05:05, 20 August 2015

Synopsis

  • Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
  • Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG).
  • Cannabis-derived cannabinoids are known as phytocannabinoids.
  • THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. PMID PMID

Anticholinergic properties of THC

  • THC inhibit anticholinesterase (AChE) induced beta-amyloid aggregation in Alzheimer's disease: PMID
  • THC as antiglutamatergic therapy for AChE induced neurotoxicity: PMID PMID PMID
  • Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE

Proneurogenic effect of THC on neurogenesis

  • Regulation of stress-induced neuroinflammation in the hippocampus.
  • Hippocampal neurogenesis is enhanced. PMID PMID
  • CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. PMID

Experimental

  • Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development.
  • Δ9-THC/DHEA ligands (synaptamide) affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.

References

  1. https://en.wikipedia.org/wiki/Cannabinoid

See also

Retrieved from "https://openwetware.org/mediawiki/index.php?title=User:Tkadm30/Notebook/THC&oldid=897068"