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'''This page has moved [https://www.isotoperesearch.ca/wiki/index.php?title=THC here]''' | |||
=== | __TOC__ | ||
===Synopsis=== | |||
* Delta(9)-tetrahydrocannabinol (THC) is the main psychoactive constituent of the Cannabis sativa L (Marijuana) plant. | |||
* Others marijuana-derived cannabinoids includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), and Tetrahydrocannabivarin (THCV). | |||
* Marijuana-derived cannabinoids are known as phytocannabinoids. | |||
* THCA is the biosynthetic precursor of THC. | |||
# https://en.wikipedia.org/wiki/Tetrahydrocannabinol | ===Antidepressant properties of THC=== | ||
* THC may stimulate anandamide mobilization(?) by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. <cite>Website2</cite> | |||
===Neuroprotective properties of THC=== | |||
====Alzheimer==== | |||
* THC may inhibit acetylcholinesterase-induced intraneuronal amyloid beta aggregation in Alzheimer's disease. <cite>Eubanks-2006</cite> | |||
* THC may prevent intracellular amyloid beta proteotoxicity and inflammatory response. <cite>Website4</cite> | |||
====Drug-induced dopamine supersensitivity==== | |||
* THC is high-affinity dopamine agonist for reversing drug-induced dopamine supersensitivity. <cite>Pope-2010</cite> | |||
====Cognitive aging==== | |||
* THC may reverse the cognitive aging process in the brain. (Reference needed) | |||
====Glaucoma==== | |||
* THC may reduce intraocular pressure (IOP) in retinal ganglion cells (RGCs) through intracellular CB1 receptor activation. | |||
** A potential treatment for glaucoma to prevent optic nerve damage. | |||
====Tardive diskinesia==== | |||
* [https://www.mrnice.nl/forum/9-patients-forum/15850-cannabinoids-prevention-management-tardive-diskinesia.html Cannabinoids for prevention and management of tardive diskinesia?] | |||
====Traumatic brain injury==== | |||
* Do THC exert a neuroprotective effect on TBI? | |||
** Review: https://www.ncbi.nlm.nih.gov/pubmed/25264643 | |||
====Posttraumatic stress disorder==== | |||
* THC may reduce chronic nightmares frequency and alter dreaming activity? | |||
====Sleep regulation==== | |||
* THC may affect REM-sleep rebound. <cite>Murillo-2003</cite> | |||
* THC may reduce REM-sleep and increase slow wave sleep (SWS). | |||
===Effects of THC on neurogenesis, synaptogenesis and BDNF signaling=== | |||
* Hippocampal CB1 receptors regulate stress-induced neuroinflammation in the hippocampus. <cite>Zoppi-2011</cite> | |||
* THC enhance adult hippocampal neurogenesis and BDNF signaling through intracellular CB1 receptor activation. <cite>Jiang-2005</cite><cite>Campbell-2007</cite> | |||
* Intracellular CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. <cite>Xapelli-2013</cite> | |||
===Neuropsychology of THC tolerance=== | |||
* CB1 receptor sensitization can be restored by taking breaks of oral THC administration. (Reference needed) | |||
* Alcohol increase THC levels in blood. (Reference needed) | |||
* THC tolerance is genetic and regulated by the AKT1 gene. | |||
===Notes=== | |||
* THC may increase serotonergic tone. <cite>Nutt-2011</cite> | |||
* '''Possible cross-talk between dopaminergic vitamin D, delta9-THC, and endogenous cannabinoids (anandamide) ?''' | |||
===Experimental=== | |||
* Endogenous retrograde trafficking may promote hippocampal development (neurogenesis) and synaptogenesis. | |||
* Arachidonic acid/DHA levels affect neural stem/progenitor cells (NSPCs) proliferation in the hippocampus. (Reference needed) | |||
* THC may enhance corticostriatal functional connectivity though increased c-Fos expression. <cite>Todd-2016</cite> | |||
* Long-term THC administration may depletes melatonin synthesis. | |||
===References=== | |||
<biblio> | |||
#Eubanks-2006 https://www.ncbi.nlm.nih.gov/pubmed/17140265 | |||
//A molecular link between the active component of marijuana and Alzheimer's disease pathology. | |||
#Pope-2010 https://www.ncbi.nlm.nih.gov/pubmed/19969019 | |||
//Endocannabinoid signaling in neurotoxicity and neuroprotection. | |||
#Jiang-2005 https://www.ncbi.nlm.nih.gov/pubmed/16224541 | |||
//Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. | |||
#Campbell-2007 https://www.ncbi.nlm.nih.gov/pubmed/17828287 | |||
//Alzheimer's disease; taking the edge off with cannabinoids? | |||
#Xapelli-2013 https://www.ncbi.nlm.nih.gov/pubmed/23704915 | |||
//Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures. | |||
#Zoppi-2011 https://www.ncbi.nlm.nih.gov/pubmed/21150911 | |||
//Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation. | |||
#Website2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/ | |||
//Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. | |||
#Website4 http://www.nature.com/articles/npjamd201612 | |||
//Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. | |||
#Xiong-2011 https://www.ncbi.nlm.nih.gov/pubmed/21460829 | |||
//Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. | |||
#Gorzo-2017 https://www.ncbi.nlm.nih.gov/pubmed/28481360 | |||
//A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice. | |||
#Nutt-2011 https://www.ncbi.nlm.nih.gov/pubmed/22045940 | |||
//Low serotonergic tone and elevated risk for substance misuse. | |||
#Todd-2016 https://www.ncbi.nlm.nih.gov/pubmed/26377899 | |||
//Neural correlates of interactions between cannabidiol and Δ(9) -tetrahydrocannabinol in mice: implications for medical cannabis. | |||
#Nguyen-2014 https://www.ncbi.nlm.nih.gov/pubmed/25264643 | |||
//Effect of marijuana use on outcomes in traumatic brain injury. | |||
#Murillo-2003 https://www.ncbi.nlm.nih.gov/pubmed/12895525 | |||
//Potential role of the cannabinoid receptor CB1 in rapid eye movement sleep rebound. | |||
</biblio> | |||
===See also=== | |||
* [[User:Etienne_Robillard/Notebook/AKT1|AKT1 Notebook]] | |||
* [[User:Etienne_Robillard/Notebook/TRPV1|TRPV1 Notebook]] | |||
* [[User:Etienne_Robillard/Notebook/THCV|THCV Notebook]] | |||
* [[User:Etienne_Robillard/Notebook/Endocannabinoids|Endocannabinoids Notebook]] | |||
* [https://en.wikipedia.org/wiki/Cannabinoid Cannabinoid] | |||
* [https://en.wikipedia.org/wiki/Tetrahydrocannabinol Tetrahydrocannabinol] | |||
* [https://en.wikipedia.org/wiki/Tetrahydrocannabinolic_acid THCA] | |||
* [https://www.thenakedscientists.com/forum/index.php?topic=65952.0 What are the effects of THC tolerance?] |
Latest revision as of 14:58, 2 October 2018
This page has moved here
Synopsis
- Delta(9)-tetrahydrocannabinol (THC) is the main psychoactive constituent of the Cannabis sativa L (Marijuana) plant.
- Others marijuana-derived cannabinoids includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), and Tetrahydrocannabivarin (THCV).
- Marijuana-derived cannabinoids are known as phytocannabinoids.
- THCA is the biosynthetic precursor of THC.
Antidepressant properties of THC
- THC may stimulate anandamide mobilization(?) by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [1]
Neuroprotective properties of THC
Alzheimer
- THC may inhibit acetylcholinesterase-induced intraneuronal amyloid beta aggregation in Alzheimer's disease. [2]
- THC may prevent intracellular amyloid beta proteotoxicity and inflammatory response. [3]
Drug-induced dopamine supersensitivity
- THC is high-affinity dopamine agonist for reversing drug-induced dopamine supersensitivity. [4]
Cognitive aging
- THC may reverse the cognitive aging process in the brain. (Reference needed)
Glaucoma
- THC may reduce intraocular pressure (IOP) in retinal ganglion cells (RGCs) through intracellular CB1 receptor activation.
- A potential treatment for glaucoma to prevent optic nerve damage.
Tardive diskinesia
Traumatic brain injury
- Do THC exert a neuroprotective effect on TBI?
Posttraumatic stress disorder
- THC may reduce chronic nightmares frequency and alter dreaming activity?
Sleep regulation
- THC may affect REM-sleep rebound. [5]
- THC may reduce REM-sleep and increase slow wave sleep (SWS).
Effects of THC on neurogenesis, synaptogenesis and BDNF signaling
- Hippocampal CB1 receptors regulate stress-induced neuroinflammation in the hippocampus. [6]
- THC enhance adult hippocampal neurogenesis and BDNF signaling through intracellular CB1 receptor activation. [7][8]
- Intracellular CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. [9]
Neuropsychology of THC tolerance
- CB1 receptor sensitization can be restored by taking breaks of oral THC administration. (Reference needed)
- Alcohol increase THC levels in blood. (Reference needed)
- THC tolerance is genetic and regulated by the AKT1 gene.
Notes
- THC may increase serotonergic tone. [10]
- Possible cross-talk between dopaminergic vitamin D, delta9-THC, and endogenous cannabinoids (anandamide) ?
Experimental
- Endogenous retrograde trafficking may promote hippocampal development (neurogenesis) and synaptogenesis.
- Arachidonic acid/DHA levels affect neural stem/progenitor cells (NSPCs) proliferation in the hippocampus. (Reference needed)
- THC may enhance corticostriatal functional connectivity though increased c-Fos expression. [11]
- Long-term THC administration may depletes melatonin synthesis.
References
-
Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.
-
A molecular link between the active component of marijuana and Alzheimer's disease pathology.
-
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids.
-
Endocannabinoid signaling in neurotoxicity and neuroprotection.
-
Potential role of the cannabinoid receptor CB1 in rapid eye movement sleep rebound.
-
Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.
-
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.
-
Alzheimer's disease; taking the edge off with cannabinoids?
-
Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures.
-
Low serotonergic tone and elevated risk for substance misuse.
-
Neural correlates of interactions between cannabidiol and Δ(9) -tetrahydrocannabinol in mice: implications for medical cannabis.
-
Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.
-
A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice.
-
Effect of marijuana use on outcomes in traumatic brain injury.