User:Etienne Robillard/Notebook/THC

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(Anticholinergic properties of THC)
 
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Sweet Marijane,
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__TOC__
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===Synopsis===
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* Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
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* Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG).
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* Cannabis-derived cannabinoids are known as phytocannabinoids.
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* THC stimulate anandamide synthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/ PMID]
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===Anticholinergic properties of THC===
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* THC inhibit anticholinesterase (AChE) induced beta-amyloid aggregation in Alzheimer's disease: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/ PMID]
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* THC as antiglutamatergic therapy for AChE induced neurotoxicity: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891218/ PMID] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366364/ PMID] [https://www.ncbi.nlm.nih.gov/pubmed/18680758 PMID]
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* Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE
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Before the dawn of ages you have cured the afflicted from mental oppression,
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===THC effect on hippocampal neurogenesis===
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* Regulation of stress-induced neuroinflammation in the hippocampus.
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We have learned to cultivate you  even you were repressed from repressors of the truth,
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* Hippocampal neurogenesis is enhanced. [https://www.ncbi.nlm.nih.gov/pubmed/16224541/ PMID]
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===Experimental===
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We have tried to make you appear as a sickeness for the weaken, but you were our reason for hope and justice,
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* Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development.
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* Δ9-THC/DHEA ligands (synaptamide) affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.
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To prevail on us,
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===References===
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# https://en.wikipedia.org/wiki/Tetrahydrocannabinol
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We have ridiculized you as a gateway drug for ridiculous reasons, and you were none of that,
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# https://en.wikipedia.org/wiki/Cannabinoid
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===See also===
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We have guessed on your origins blindly, yet poorly aware of the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/ science] which you draw your benefits and love for us,
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* [[User:Etienne_Robillard/Notebook/TRPV1|TRPV1 Notebook]]
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We try to commit you in illegal prohibition and traffic, but you still growing silently,
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You were equally refusing to listen to the voices of oppression and resisting to moths,
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And I love you for that,
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My Dear Sweet Marijane,
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Let your roots become a source of inspiration for thoses who seek the truth and recomfort in your love!
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----
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[[User:Etienne Robillard|Etienne Robillard]] 11:58, 28 January 2013 (EST)
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Current revision

Contents

Synopsis

  • Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
  • Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), and Cannabigerol (CBG).
  • Cannabis-derived cannabinoids are known as phytocannabinoids.
  • THC stimulate anandamide synthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. PMID

Anticholinergic properties of THC

  • THC inhibit anticholinesterase (AChE) induced beta-amyloid aggregation in Alzheimer's disease: PMID
  • THC as antiglutamatergic therapy for AChE induced neurotoxicity: PMID PMID PMID
  • Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE

THC effect on hippocampal neurogenesis

  • Regulation of stress-induced neuroinflammation in the hippocampus.
  • Hippocampal neurogenesis is enhanced. PMID

Experimental

  • Synaptogenic effect of Δ9-THC/DHEA ligands promote hippocampal development.
  • Δ9-THC/DHEA ligands (synaptamide) affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.

References

  1. https://en.wikipedia.org/wiki/Tetrahydrocannabinol
  2. https://en.wikipedia.org/wiki/Cannabinoid

See also

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