User:Etienne Robillard/Notebook/THC

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(Neuroprotective properties of THC)
 
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Sweet Marijane,
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__TOC__
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===Synopsis===
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* Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
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* Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), Tetrahydrocannabivarin (THCV).
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* Cannabis-derived cannabinoids are known as phytocannabinoids.
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Before the dawn of ages you have cured the afflicted from mental oppression,
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===Antidepressant properties of THC===
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* THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. <cite>Website2</cite>
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We have learned to cultivate you  even you were repressed from repressors of the truth,
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===Neuroprotective properties of THC===
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* THC inhibit acetylcholinesterase (AChE)-induced intraneuronal amyloid beta aggregation in Alzheimer's disease: <cite>Eubanks-2006</cite>
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** THC prevent intracellular amyloid beta proteotoxicity and inflammatory response: <cite>Website4</cite>
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* THC is effective as antiglutamatergic therapy for NMDA-induced excitotoxicity. <cite>Pope-2010</cite>
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* Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE.
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* THC reduce intraocular pressure (IOP) in retinal ganglion cells (RGCs) through intracellular CB1 receptor activation; A potential treatment for glaucoma to prevent optic nerve damage.
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We have tried to make you appear as a sickeness for the weaken, but you were our reason for hope and justice,  
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===Proneurogenic effect of THC on neurogenesis===
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* Hippocampal CB1 receptors regulate stress-induced neuroinflammation in the hippocampus. <cite>Zoppi-2011</cite>
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* THC enhance adult hippocampal neurogenesis through intracellular CB1 receptor activation. <cite>Jiang-2005</cite><cite>Campbell-2007</cite>
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* CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. <cite>Xapelli-2013</cite>
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===Neuropsychology of THC tolerance===
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* CB1 receptor sensitization can be restored by taking breaks of oral THC administration, which stimulates endocannabinoid production. <cite>Website3</cite>
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* Alcohol increase THC levels in blood.
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To prevail on us,
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===Experimental===
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* Synaptogenic effect of THC/DHA promote hippocampal development (neurogenesis) and synaptogenesis.
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* THC/DHA affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.
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We have ridiculized you as a gateway drug for ridiculous reasons, and you were none of that,
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===References===
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<biblio>
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#Eubanks-2006 pmid=17140265
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//A molecular link between the active component of marijuana and Alzheimer's disease pathology.
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#Pope-2010 pmid=19969019
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//Endocannabinoid signaling in neurotoxicity and neuroprotection.
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#Jiang-2005 pmid=16224541
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//Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.
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#Campbell-2007 pmid=17828287
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//Alzheimer's disease; taking the edge off with cannabinoids?
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#Xapelli-2013 pmid=23704915
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//Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures.
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#Zoppi-2011 pmid=21150911
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//Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.
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#Website1 https://en.wikipedia.org/wiki/Cannabinoid
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#Website2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/
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//Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
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#Website3 http://www.thenakedscientists.com/forum/index.php?topic=65952.0
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#Website4 http://www.nature.com/articles/npjamd201612
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//Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
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</biblio>
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We have guessed on your origins blindly, yet poorly aware of the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/ science] which you draw your benefits and love for us,
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===See also===
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* [[User:Etienne_Robillard/Notebook/TRPV1|TRPV1 Notebook]]
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We try to commit you in illegal prohibition and traffic, but you still growing silently,
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You were equally refusing to listen to the voices of oppression and resisting to moths,
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And I love you for that,
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My Dear Sweet Marijane,
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Let your roots become a source of inspiration for thoses who seek the truth and recomfort in your love!
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----
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[[User:Etienne Robillard|Etienne Robillard]] 11:58, 28 January 2013 (EST)
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Current revision

Contents

Synopsis

  • Tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L (Marijuana) plant.
  • Other Marijuana compounds includes Cannabichromene (CBC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), Tetrahydrocannabivarin (THCV).
  • Cannabis-derived cannabinoids are known as phytocannabinoids.

Antidepressant properties of THC

  • THC stimulate anandamide biosynthesis by binding to the CB1 receptor, thus producing a antidepressant and neuroprotective effect. [1]

Neuroprotective properties of THC

  • THC inhibit acetylcholinesterase (AChE)-induced intraneuronal amyloid beta aggregation in Alzheimer's disease: [2]
    • THC prevent intracellular amyloid beta proteotoxicity and inflammatory response: [3]
  • THC is effective as antiglutamatergic therapy for NMDA-induced excitotoxicity. [4]
  • Unlike THC, caffeine is a noncompetitive reversible inhibitor of AChE.
  • THC reduce intraocular pressure (IOP) in retinal ganglion cells (RGCs) through intracellular CB1 receptor activation; A potential treatment for glaucoma to prevent optic nerve damage.

Proneurogenic effect of THC on neurogenesis

  • Hippocampal CB1 receptors regulate stress-induced neuroinflammation in the hippocampus. [5]
  • THC enhance adult hippocampal neurogenesis through intracellular CB1 receptor activation. [6][7]
  • CB1 activation promote neuronal cell proliferation, differentiation, maturation, and neurite growth. [8]

Neuropsychology of THC tolerance

  • CB1 receptor sensitization can be restored by taking breaks of oral THC administration, which stimulates endocannabinoid production. [9]
  • Alcohol increase THC levels in blood.

Experimental

  • Synaptogenic effect of THC/DHA promote hippocampal development (neurogenesis) and synaptogenesis.
  • THC/DHA affect neural stem/progenitor cells (NS/PC) proliferation in the hippocampus.

References

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866040/ [Website2]
    Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L

  2. Eubanks LM, Rogers CJ, Beuscher AE 4th, Koob GF, Olson AJ, Dickerson TJ, and Janda KD. . pmid:17140265. PubMed HubMed [Eubanks-2006]
    A molecular link between the active component of marijuana and Alzheimer's disease pathology.

  3. http://www.nature.com/articles/npjamd201612 [Website4]
    Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

  4. Pope C, Mechoulam R, and Parsons L. . pmid:19969019. PubMed HubMed [Pope-2010]
    Endocannabinoid signaling in neurotoxicity and neuroprotection.

  5. Zoppi S, Pérez Nievas BG, Madrigal JL, Manzanares J, Leza JC, and García-Bueno B. . pmid:21150911. PubMed HubMed [Zoppi-2011]
    Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.

  6. Jiang W, Zhang Y, Xiao L, Van Cleemput J, Ji SP, Bai G, and Zhang X. . pmid:16224541. PubMed HubMed [Jiang-2005]
    Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.

  7. Campbell VA and Gowran A. . pmid:17828287. PubMed HubMed [Campbell-2007]
    Alzheimer's disease; taking the edge off with cannabinoids?

  8. Xapelli S, Agasse F, Sardà-Arroyo L, Bernardino L, Santos T, Ribeiro FF, Valero J, Bragança J, Schitine C, de Melo Reis RA, Sebastião AM, and Malva JO. . pmid:23704915. PubMed HubMed [Xapelli-2013]
    Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures.

  9. http://www.thenakedscientists.com/forum/index.php?topic=65952.0 [Website3]
  10. https://en.wikipedia.org/wiki/Cannabinoid [Website1]
All Medline abstracts: PubMed HubMed

See also

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