User:Etienne Robillard/Notebook/Schiff base

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Introduction to Schiff bases

  • Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of Schiff base formation. [1]
  • Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .

Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion

  • For the long story, see Phenylmethylamine: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a enamine. See also Ethanamine. Note that the C=N double bond is the result (product) of asymmetric synthesis (Micheal addition) in presence of a organometal catalyst.
  • assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
    • Additional data is provided in EC 2.1.1.28 to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -ER
    • 2ATP/2PD: Check/verify the tri-stable RNA polymerase repressor functions (LuxR) and AHL (PD riboswitch?) evidences in the design of schiff base conjugated C6 (hexanoyl) psychochemicals to

induce RNA activated transcription and metabolism. -ER

    • Verify this lazy RNA polymerase function: 2ATP+CO2->Ph2CO<=>2(N+2(R)+OH) -ER

References

  1. http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation
  2. http://www.wikigenes.org/e/chem/e/7046.html
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