User:Etienne Robillard/Notebook/Schiff base

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(The Monsanto connection: Troika acids; Novel cyanophosphonate compounds as disubstituted Schiff bases ?)
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=== Introduction to Schiff bases ===
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== Back to aryl-ketone chemistry ==
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===Glossary===
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* "Schiff Base": A perturbating type (class) of imine.
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* "Active Methylene Enolate":  A compound derived from an imide or product of a Micheal addition.
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===Learning resources===
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Learning resources:
 
* Part 1: [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]  
* Part 1: [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]  
* Part 2: [http://www.chem.ucalgary.ca/courses/350/Carey5th/Ch21/ch21-4-3.html Micheal reaction]
* Part 2: [http://www.chem.ucalgary.ca/courses/350/Carey5th/Ch21/ch21-4-3.html Micheal reaction]
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* Question 3 (bonus question) : In your own words, describe the role of a synthase enzyme (without the help of Wikipedia!) in the phosphorylation of ATP.
* Question 3 (bonus question) : In your own words, describe the role of a synthase enzyme (without the help of Wikipedia!) in the phosphorylation of ATP.
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=== Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :) ===
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=== Cationic Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :) ===
"The individual has always had to struggle to keep from being overwhelmed
"The individual has always had to struggle to keep from being overwhelmed
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** Remote activation of <font color=purple>Gold</font> (Yb) nanoparticles ? hmm.. star trek style drug delivery :)
** Remote activation of <font color=purple>Gold</font> (Yb) nanoparticles ? hmm.. star trek style drug delivery :)
** Amphetamine-induced alcoholism and locomotor hyperactivity syndrom:  
** Amphetamine-induced alcoholism and locomotor hyperactivity syndrom:  
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** '''hydrochloric acid based hydrolysis of hydrocyanic (-rC=N) (synthetic) (re)agents.''' (keywords: Ugi, Isocyanide, Purine degradation, N-methyltransferase, 1.1.1.1, [http://www.1911encyclopedia.org/Formic_acid Formic acid]
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** '''hydrochloric acid (hcl) based hydrolysis of hydrocyanic (-rC=N) (synthetic) (re)agents.'''  
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*** keywords: Ugi, Isocyanide, Purine degradation, N-methyltransferase (Adenosine?), 1.1.1.1, [http://www.1911encyclopedia.org/Formic_acid Formic acid]
** Armstrong/Keating convertible isonitrile synthesis ('''1995'''): DOI: 10.1021/ja00134a044  
** Armstrong/Keating convertible isonitrile synthesis ('''1995'''): DOI: 10.1021/ja00134a044  
** [http://pubs.acs.org/doi/abs/10.1021/ja953868b "Postcondensation Modifications of Ugi Four-Component Condensation Products:  '''1-Isocyanocyclohexene''' as a Convertible Isocyanide. Mechanism of Conversion, Synthesis of Diverse Structures, and Demonstration of Resin Capture"] ('''1996''')  
** [http://pubs.acs.org/doi/abs/10.1021/ja953868b "Postcondensation Modifications of Ugi Four-Component Condensation Products:  '''1-Isocyanocyclohexene''' as a Convertible Isocyanide. Mechanism of Conversion, Synthesis of Diverse Structures, and Demonstration of Resin Capture"] ('''1996''')  
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Notes:
Notes:
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=== The Monsanto connection: Troika acids; Novel cyanophosphonate compounds as disubstituted Schiff bases ? ===
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===Voltage-gated Troika acids (functionalized diphosphines/cyanophosphonates); The Chim Trills connection deepens the bliss of ignorance, total surveillance, and mental tyranny :)===
* US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
* US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
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** See notes [https://openwetware.org/wiki/User:Etienne_Robillard/Notebook/Agent_Ecoli:PhotoReceptorComponent here] on Rhodopsin mediated [[User:Etienne_Robillard/Notebook/Autophosphorylation autophosphorylation]].
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* US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base)  
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** Furthermore "polyhistidine" might suggest a few things..
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* US6169192 (functionalized diphosphines stuff)
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* US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base) (ie: <font color=purple>for binding ca2+/mg2+ ions to a recombinant "fusion" protein...</font>)
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* Chuck: If you want to spray civilians without impunity, be sure to include a cyanoethyl moeity...
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* Oracle: Are you kidding? Once upon a time cyanide was at the basis of the Zyklon-b pellet...
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* Oracle: Hence, the magnitude and scale of civilians exposure to the new compound is probably most effective today.
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* Chuck: For next time, how about a ban of spraying civilians with pharmacochemical intermediates ?
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* Oracle: Go ask Obama!
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* Chuck: LOL
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* Oracle: Go ask Monsanto! When should it become natural to breath air ? Is this a luxury reserved for an elite golf club ?
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* Chuck: And Is this the reason I'm being emprisonned ?
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* Chuck: Because I refuse to happily breath such things while the majority of the breed have no clue what the heck a troika acid is composed of?
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=== References ===
=== References ===

Current revision

Contents

Back to aryl-ketone chemistry

Glossary

  • "Schiff Base": A perturbating type (class) of imine.
  • "Active Methylene Enolate": A compound derived from an imide or product of a Micheal addition.

Learning resources

Schiff bases conjugated pharmacological intermediates and N-substituted heterocyclics carbenes

  • Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
    • pharmacological intermediates (N-substituted heterocyclics)
    • Nucleophilic carbonyl addition
    • PS: Yb(OTf)3 route to 1,2,3,4-tetrahydroisoquinolines derivatives.
    • Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)

Schiff bases as quorum sensing molecules (AHL) and Serine-dependent osmolitic regulators/ATP synthase

  • Question 1 : In your own words, explain at least 2 functions of the envZ/30C6HSL (ATP-dependent) synthetase in E. coli.
  • Question 2 : How is EnvZ relevant to CES (ADA) and specifically the CAMK2G gene?
  • Note: Further info on Phenylmethylamine substituted beta-amyloid ligands (APP) are here.
  • Question 3 (bonus question) : In your own words, describe the role of a synthase enzyme (without the help of Wikipedia!) in the phosphorylation of ATP.

Cationic Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :)

"The individual has always had to struggle to keep from being overwhelmed by the tribe. If you try it, you will be lonely often, and sometimes frightened. But no price is too high to pay for the privilege of owning yourself." -Friedrich Nietzsche

Learning modules:

Learning topics:

Notes:

Voltage-gated Troika acids (functionalized diphosphines/cyanophosphonates); The Chim Trills connection deepens the bliss of ignorance, total surveillance, and mental tyranny :)

  • US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
  • US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base)
  • US6169192 (functionalized diphosphines stuff)

References

  1. Imine (Schiff base) formation - Highly recommended primer documentation on Schiff bases
  2. http://www.wikigenes.org/e/chem/e/7046.html - 1,2,3,4-tetrahydroisoquinoline. (Note: A anti-malarial pharmaceutical compound comparable to mefloquine. Compound may be implicated in 4-trans like enantiomer substitution (conformational) leading to acute psychotic hallucinations. See: Arylcyclohexylamines and this document for a more concise explanation.)

Synthesis and conformational rearrangement of benzoxadiazole derivatives with disubstituted (-N=Ph[2]C) isocyanate ligands [phosphoramido-cyanidate]

  1. DOI:10.1021/ja00132a045 [ISOCYANIDES1]
  2. DOI:10.1002/anie.197205301 [ISOCYANIDES2] (Hofmann/Ugi route to PS, Wilmslow)
  3. http://www.ncbi.nlm.nih.gov/pubmed/16953613
  4. http://www.nizkor.org/ftp.cgi/camps/auschwitz/cyanide/cyanide.001
  5. http://www.state.gov/www/global/arms/treaties/cwc/cwcann.html - In Schedule 1A(2), Schedule 2B(6)

Tyrosine kinase (GPCR) signaling with Troika acids (disubstituted Chair Conformer Cyclohexane Ring system):

  1. Protein Tyrosine Kinases and Protein Tyrosine Phosphatases Are Involved in Abscisic Acid-Dependent Processes in Arabidopsis Seeds and Suspension Cells
  2. Small Ubiquitin-Like Modifier Modulates Abscisic Acid Signaling in Arabidopsis
  3. cis/trans stuff (Look for section "Conformational Structures of Disubstituted Cyclohexanes", 4th row from the top) : http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/sterism2.htm

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'"Attitude is a little thing that makes a big difference." - Winston Churchill

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