User:Etienne Robillard/Notebook/Schiff base

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(Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :))
(Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :))
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=== Introduction to Schiff bases ===
=== Introduction to Schiff bases ===
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* Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]  
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Learning resources:
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* Part 1: [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]
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* Part 2: [http://www.chem.ucalgary.ca/courses/350/Carey5th/Ch21/ch21-4-3.html Micheal reaction]
=== Schiff bases conjugated pharmacological intermediates and N-substituted heterocyclics carbenes ===
=== Schiff bases conjugated pharmacological intermediates and N-substituted heterocyclics carbenes ===
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=== Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :) ===
=== Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :) ===
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Student resources:
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"The individual has always had to struggle to keep from being overwhelmed
 +
by the tribe. If you try it, you will be lonely often, and sometimes
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frightened. But no price is too high to pay for the privilege of owning
 +
yourself." -Friedrich Nietzsche
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 +
Learning modules:
* [[User:Etienne_Robillard/Notebook/Phenylmethanamine|Phenylmethanamine]]
* [[User:Etienne_Robillard/Notebook/Phenylmethanamine|Phenylmethanamine]]
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* [[Ethanamine]]
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* [[Acetaldehyde|Acetaldehyde]]
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* [[User:Etienne_Robillard/Notebook/Chloroform|Chloroform]]
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* [[User:Etienne_Robillard/Notebook/NMDA_dependent_cell_adhesion|NMDA dependent cell adhesion]]
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* [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]]
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Teaching Topics:
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Learning topics:
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* Troika acids
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* NMDAR-induced neurotoxicity of cyanophosphate-derived cross-linker reagents exposure
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* Toxicity of cyanophosphate-derived cross-linker reagents exposure : Alcoholism like psychotic symptoms. Acute psychotic (visual..) hallucinations (Note: Long-term rehabilitation is often necessary.. :)
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* NMDAR-induced Alcoholism like psychotic symptoms.  
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* Effects of cyanide on Yb(OTf)3 conformational polypeptide (1,2,3,4-tetrahydroisoquinolines) isomerisation ?
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* NMDAR-induced visual hallucinations.
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* Remote activation of <font color=purple>Gold</font> (Yb) nanoparticles ? hmm.. star trek style drug delivery :)
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* NMDAR-induced benzylamine synthesis.  
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* 30C6HSL (aka Ugi route to Wilmslow)
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** disubstituted isocyanide/gold nanoparticle synthetic protein condensation ? (LuxR, Yb(OTf)3, etc)  
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** Remote activation of <font color=purple>Gold</font> (Yb) nanoparticles ? hmm.. star trek style drug delivery :)
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** Amphetamine-induced alcoholism and locomotor hyperactivity syndrom:
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** '''hydrochloric acid based hydrolysis of hydrocyanic (-rC=N) (synthetic) (re)agents.''' (keywords: Ugi, Isocyanide, Purine degradation, N-methyltransferase, 1.1.1.1, [http://www.1911encyclopedia.org/Formic_acid Formic acid]
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** Armstrong/Keating convertible isonitrile synthesis ('''1995'''): DOI: 10.1021/ja00134a044
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** [http://pubs.acs.org/doi/abs/10.1021/ja953868b "Postcondensation Modifications of Ugi Four-Component Condensation Products:  '''1-Isocyanocyclohexene''' as a Convertible Isocyanide. Mechanism of Conversion, Synthesis of Diverse Structures, and Demonstration of Resin Capture"] ('''1996''')  
Notes:
Notes:
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* <font color=purple>'''The C=N double bond linkage may be a result (product) of asymmetric synthesis (<font color="red">Micheal addition</font>) in presence of a organometal catalyst. [1]</font> [[Image:500px-Diethyl cyanophosphate.svg.png|thumb|right|Example cyanophosphate-derived synthetic reagent. (PMID: 1818086, 15670935)]]
 
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* Assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
 
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* Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.1.28&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 EC 2.1.1.28] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]]
 
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* tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable mRNA polymerase repressor functions (LuxR) and AHL evidences in the design of <font color="red">Schiff base conjugated (6xHis tag) psychochemicals to induce (lazy) light-activated mRNA transcription and metabolism</font>. -[[User:Etienne_Robillard|ER]]
 
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* Also Verify this lazy RNA polymerase function: <math>2ATP+CO^2->Ph^2CO<=>2N+2ROH</math> -[[User:Etienne_Robillard|ER]]
 
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* carbanion = cyanide anion
 
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* 6his-tag = a C6 hexanoyl based heterocyclic carbanion -- N-substituted oxazoles derivatives (imine)
 
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=== The Monsanto connection: Troika acids; novel cyanophosphonate compounds as N-substituted (alkyl) drug carrier (pharmacochemical intermediates) ===
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=== The Monsanto connection: Troika acids; Novel cyanophosphonate compounds as disubstituted Schiff bases ? ===
* US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
* US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
* US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base) (ie: <font color=purple>for binding ca2+/mg2+ ions to a recombinant "fusion" protein...</font>)
* US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base) (ie: <font color=purple>for binding ca2+/mg2+ ions to a recombinant "fusion" protein...</font>)
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# [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Imine (Schiff base) formation] - Highly recommended primer documentation on Schiff bases
# [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Imine (Schiff base) formation] - Highly recommended primer documentation on Schiff bases
# http://www.wikigenes.org/e/chem/e/7046.html - 1,2,3,4-tetrahydroisoquinoline. (Note: A anti-malarial pharmaceutical compound comparable to mefloquine. Compound may be implicated in 4-trans like enantiomer substitution (conformational) leading to '''acute psychotic hallucinations'''. See: [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]] and [http://chemistry.umeche.maine.edu/CHY251/cyclo6.html this document] for a more concise explanation.)   
# http://www.wikigenes.org/e/chem/e/7046.html - 1,2,3,4-tetrahydroisoquinoline. (Note: A anti-malarial pharmaceutical compound comparable to mefloquine. Compound may be implicated in 4-trans like enantiomer substitution (conformational) leading to '''acute psychotic hallucinations'''. See: [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]] and [http://chemistry.umeche.maine.edu/CHY251/cyclo6.html this document] for a more concise explanation.)   
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# 10.1021/ja00132a045  
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<font color=purple style="background:#ddd">Synthesis and conformational rearrangement of benzoxadiazole derivatives with disubstituted (-N=Ph[2]C) isocyanate ligands [phosphoramido-cyanidate]</font>
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# DOI:10.1021/ja00132a045 [ISOCYANIDES1]
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# DOI:10.1002/anie.197205301 [ISOCYANIDES2] (<font color=purple style="background: #ddd">Hofmann/Ugi route to PS, Wilmslow</font>)
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# http://www.ncbi.nlm.nih.gov/pubmed/16953613
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# http://www.nizkor.org/ftp.cgi/camps/auschwitz/cyanide/cyanide.001
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# http://www.state.gov/www/global/arms/treaties/cwc/cwcann.html - In Schedule 1A(2), Schedule 2B(6)
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Tyrosine kinase (GPCR) signaling with Troika acids (disubstituted Chair Conformer Cyclohexane Ring system):
Tyrosine kinase (GPCR) signaling with Troika acids (disubstituted Chair Conformer Cyclohexane Ring system):
# ​[http://www.plantphysiol.org/content/148/3/1668 Protein Tyrosine Kinases and Protein Tyrosine Phosphatases Are Involved in Abscisic Acid-Dependent Processes in Arabidopsis Seeds and Suspension Cells]
# ​[http://www.plantphysiol.org/content/148/3/1668 Protein Tyrosine Kinases and Protein Tyrosine Phosphatases Are Involved in Abscisic Acid-Dependent Processes in Arabidopsis Seeds and Suspension Cells]

Revision as of 08:17, 30 June 2013

Contents

Introduction to Schiff bases

Learning resources:

Schiff bases conjugated pharmacological intermediates and N-substituted heterocyclics carbenes

  • Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
    • pharmacological intermediates (N-substituted heterocyclics)
    • Nucleophilic carbonyl addition
    • PS: Yb(OTf)3 route to 1,2,3,4-tetrahydroisoquinolines derivatives.
    • Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)

Schiff bases as quorum sensing molecules (AHL) and Serine-dependent osmolitic regulators/ATP synthase

  • Question 1 : In your own words, explain at least 2 functions of the envZ/30C6HSL (ATP-dependent) synthetase in E. coli.
  • Question 2 : How is EnvZ relevant to CES (ADA) and specifically the CAMK2G gene?
  • Note: Further info on Phenylmethylamine substituted beta-amyloid ligands (APP) are here.
  • Question 3 (bonus question) : In your own words, describe the role of a synthase enzyme (without the help of Wikipedia!) in the phosphorylation of ATP.

Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :)

"The individual has always had to struggle to keep from being overwhelmed by the tribe. If you try it, you will be lonely often, and sometimes frightened. But no price is too high to pay for the privilege of owning yourself." -Friedrich Nietzsche

Learning modules:

Learning topics:

Notes:

The Monsanto connection: Troika acids; Novel cyanophosphonate compounds as disubstituted Schiff bases ?

  • US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
  • US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base) (ie: for binding ca2+/mg2+ ions to a recombinant "fusion" protein...)
  • Chuck: If you want to spray civilians without impunity, be sure to include a cyanoethyl moeity...
  • Oracle: Are you kidding? Once upon a time cyanide was at the basis of the Zyklon-b pellet...
  • Oracle: Hence, the magnitude and scale of civilians exposure to the new compound is probably most effective today.
  • Chuck: For next time, how about a ban of spraying civilians with pharmacochemical intermediates ?
  • Oracle: Go ask Obama!
  • Chuck: LOL
  • Oracle: Go ask Monsanto! When should it become natural to breath air ? Is this a luxury reserved for an elite golf club ?
  • Chuck: And Is this the reason I'm being emprisonned ?
  • Chuck: Because I refuse to happily breath such things while the majority of the breed have no clue what the heck a troika acid is composed of?

References

  1. Imine (Schiff base) formation - Highly recommended primer documentation on Schiff bases
  2. http://www.wikigenes.org/e/chem/e/7046.html - 1,2,3,4-tetrahydroisoquinoline. (Note: A anti-malarial pharmaceutical compound comparable to mefloquine. Compound may be implicated in 4-trans like enantiomer substitution (conformational) leading to acute psychotic hallucinations. See: Arylcyclohexylamines and this document for a more concise explanation.)

Synthesis and conformational rearrangement of benzoxadiazole derivatives with disubstituted (-N=Ph[2]C) isocyanate ligands [phosphoramido-cyanidate]

  1. DOI:10.1021/ja00132a045 [ISOCYANIDES1]
  2. DOI:10.1002/anie.197205301 [ISOCYANIDES2] (Hofmann/Ugi route to PS, Wilmslow)
  3. http://www.ncbi.nlm.nih.gov/pubmed/16953613
  4. http://www.nizkor.org/ftp.cgi/camps/auschwitz/cyanide/cyanide.001
  5. http://www.state.gov/www/global/arms/treaties/cwc/cwcann.html - In Schedule 1A(2), Schedule 2B(6)

Tyrosine kinase (GPCR) signaling with Troika acids (disubstituted Chair Conformer Cyclohexane Ring system):

  1. Protein Tyrosine Kinases and Protein Tyrosine Phosphatases Are Involved in Abscisic Acid-Dependent Processes in Arabidopsis Seeds and Suspension Cells
  2. Small Ubiquitin-Like Modifier Modulates Abscisic Acid Signaling in Arabidopsis
  3. cis/trans stuff (Look for section "Conformational Structures of Disubstituted Cyclohexanes", 4th row from the top) : http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/sterism2.htm

Did you know?

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