User:Etienne Robillard/Notebook/Schiff base

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(Introduction to Schiff bases)
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* Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]  
* Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]  
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* Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .  
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* Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
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** pharmacological intermediates (N-substituted heterocyclics)
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** Nucleophilic carbonyl addition
=== Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion ===
=== Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion ===

Revision as of 08:07, 12 March 2013

Introduction to Schiff bases

  • Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of Schiff base formation. [1]
  • Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
    • pharmacological intermediates (N-substituted heterocyclics)
    • Nucleophilic carbonyl addition

Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion

  • For the long story, see Phenylmethylamine: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a enamine. See also Ethanamine. Note that the C=N double bond is the result (product) of asymmetric synthesis (Micheal addition) in presence of a organometal catalyst.
  • assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
  • Additional data is provided in EC 2.1.1.28 to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -ER
  • tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable RNA polymerase repressor functions (LuxR) and AHL evidences in the design of Schiff base conjugated C6 (hexanoyl) psychochemicals to induce (lazy) light-activated RNA transcription and metabolism. -ER
  • Verify this lazy RNA polymerase function: 2ATP+CO2->Ph2CO<=>2(N+2(R)+OH) -ER

References

  1. http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation
  2. http://www.wikigenes.org/e/chem/e/7046.html
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