User:Etienne Robillard/Notebook/Schiff base

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(Voltage-gated Troika acids (functionalized diphosphines/cyanophosphonates); The Chim Trills connection deepens the bliss of ignorance, total surveillance, and mental tyranny!)
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== Back to aryl-ketone chemistry ==
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===Glossary===
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* "Schiff Base": A perturbating type (class) of imine.
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* "Active Methylene Enolate":  A compound derived from an imide or product of a Micheal addition.
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===Learning resources===
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* Part 1: [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]
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* Part 2: [http://www.chem.ucalgary.ca/courses/350/Carey5th/Ch21/ch21-4-3.html Micheal reaction]
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=== Schiff bases conjugated pharmacological intermediates and N-substituted heterocyclics carbenes ===
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* Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
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** pharmacological intermediates (N-substituted heterocyclics)
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** Nucleophilic carbonyl addition
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** PS: <font color="red">Yb(OTf)3</font> route to '''1,2,3,4-tetrahydroisoquinolines''' derivatives.
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** Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)
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=== Schiff bases as quorum sensing molecules (AHL) and Serine-dependent osmolitic regulators/ATP synthase ===
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* Question 1 : In your own words, explain at least 2 functions of the envZ/30C6HSL (ATP-dependent) synthetase in E. coli.
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* Question 2 : How is EnvZ relevant to CES (ADA) and specifically the CAMK2G gene?
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* Note: Further info on Phenylmethylamine substituted beta-amyloid ligands (APP) are [[User:Etienne_Robillard/Notebook/Phenylmethylamine|here]].
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* Question 3 (bonus question) : In your own words, describe the role of a synthase enzyme (without the help of Wikipedia!) in the phosphorylation of ATP.
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=== Troika acids; Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl Carbanion (Cyanide) ligands : 4-trans-7-aminoalkylamino-2,1,3-benzoxadiazoles, 1,2-dimethylcyclohexanes and friends :) ===
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"The individual has always had to struggle to keep from being overwhelmed
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by the tribe. If you try it, you will be lonely often, and sometimes
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frightened. But no price is too high to pay for the privilege of owning
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yourself." -Friedrich Nietzsche
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Learning modules:
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* [[User:Etienne_Robillard/Notebook/Phenylmethanamine|Phenylmethanamine]]
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* [[Acetaldehyde|Acetaldehyde]]
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* [[User:Etienne_Robillard/Notebook/Chloroform|Chloroform]]
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* [[User:Etienne_Robillard/Notebook/NMDA_dependent_cell_adhesion|NMDA dependent cell adhesion]]
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* [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]]
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Learning topics:
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* NMDAR-induced neurotoxicity of cyanophosphate-derived cross-linker reagents exposure
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* NMDAR-induced Alcoholism like psychotic symptoms.
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* NMDAR-induced visual hallucinations.
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* NMDAR-induced benzylamine synthesis.
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* 30C6HSL (aka Ugi route to Wilmslow)
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** disubstituted isocyanide/gold nanoparticle synthetic protein condensation ? (LuxR, Yb(OTf)3, etc)
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** Remote activation of <font color=purple>Gold</font> (Yb) nanoparticles ? hmm.. star trek style drug delivery :)
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** Amphetamine-induced alcoholism and locomotor hyperactivity syndrom:
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** '''hydrochloric acid (hcl) based hydrolysis of hydrocyanic (-rC=N) (synthetic) (re)agents.'''
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*** keywords: Ugi, Isocyanide, Purine degradation, N-methyltransferase (Adenosine?), 1.1.1.1, [http://www.1911encyclopedia.org/Formic_acid Formic acid]
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** Armstrong/Keating convertible isonitrile synthesis ('''1995'''): DOI: 10.1021/ja00134a044
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** [http://pubs.acs.org/doi/abs/10.1021/ja953868b "Postcondensation Modifications of Ugi Four-Component Condensation Products:  '''1-Isocyanocyclohexene''' as a Convertible Isocyanide. Mechanism of Conversion, Synthesis of Diverse Structures, and Demonstration of Resin Capture"] ('''1996''')
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Notes:
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===Voltage-gated Troika acids (functionalized diphosphines/cyanophosphonates); The Chim Trills connection deepens the bliss of ignorance, total surveillance, and mental tyranny :)===
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* US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
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* US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base)
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* US6169192 (functionalized diphosphines stuff)
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=== References ===
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# [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Imine (Schiff base) formation] - Highly recommended primer documentation on Schiff bases
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# http://www.wikigenes.org/e/chem/e/7046.html - 1,2,3,4-tetrahydroisoquinoline. (Note: A anti-malarial pharmaceutical compound comparable to mefloquine. Compound may be implicated in 4-trans like enantiomer substitution (conformational) leading to '''acute psychotic hallucinations'''. See: [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]] and [http://chemistry.umeche.maine.edu/CHY251/cyclo6.html this document] for a more concise explanation.) 
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<font color=purple style="background:#ddd">Synthesis and conformational rearrangement of benzoxadiazole derivatives with disubstituted (-N=Ph[2]C) isocyanate ligands [phosphoramido-cyanidate]</font>
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# DOI:10.1021/ja00132a045 [ISOCYANIDES1]
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# DOI:10.1002/anie.197205301 [ISOCYANIDES2] (<font color=purple style="background: #ddd">Hofmann/Ugi route to PS, Wilmslow</font>)
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# http://www.ncbi.nlm.nih.gov/pubmed/16953613
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# http://www.nizkor.org/ftp.cgi/camps/auschwitz/cyanide/cyanide.001
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# http://www.state.gov/www/global/arms/treaties/cwc/cwcann.html - In Schedule 1A(2), Schedule 2B(6)
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Tyrosine kinase (GPCR) signaling with Troika acids (disubstituted Chair Conformer Cyclohexane Ring system):
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# ​[http://www.plantphysiol.org/content/148/3/1668 Protein Tyrosine Kinases and Protein Tyrosine Phosphatases Are Involved in Abscisic Acid-Dependent Processes in Arabidopsis Seeds and Suspension Cells]
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# [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156371/ Small Ubiquitin-Like Modifier Modulates Abscisic Acid Signaling in Arabidopsis]
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# cis/trans stuff (Look for section "Conformational Structures of Disubstituted Cyclohexanes", 4th row from the top) : http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/sterism2.htm
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=== Did you know? ===
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'"Attitude is a little thing that makes a big difference." - Winston Churchill
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