User:Etienne Robillard/Notebook/Schiff base

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(The Monsanto connection: Troika acids; novel cyanophosphonate compounds as N-substituted (alkyl) drug carrier (pharmacochemical intermediates))
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=== Introduction to Schiff bases ===
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* Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]
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=== Schiff bases conjugated pharmacological intermediates and N-substituted heterocyclics carbenes ===
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* Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
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** pharmacological intermediates (N-substituted heterocyclics)
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** Nucleophilic carbonyl addition
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** PS: <font color="red">Yb(OTf)3</font> route to '''1,2,3,4-tetrahydroisoquinolines''' derivatives.
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** Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)
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=== Schiff bases as quorum sensing molecules (AHL) and Serine-dependent osmolitic regulators/ATP synthase ===
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* Question 1 : In your own words, explain at least 2 functions of the envZ/30C6HSL (ATP-dependent) synthetase in E. coli.
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* Question 2 : How is EnvZ relevant to CES (ADA) and specifically the CAMK2G gene?
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* Note: Further info on Phenylmethylamine substituted beta-amyloid ligands (APP) are [[User:Etienne_Robillard/Notebook/Phenylmethylamine|here]].
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* Question 3 (bonus question) : In your own words, describe the role of a synthase enzyme (without the help of Wikipedia!) in the phosphorylation of ATP.
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=== Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion ===
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* For the long story, see [[Phenylmethylamine]]: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a '''enamine'''. See also [[Ethanamine]]. Note that the C=N double bond is the result (product) of asymmetric synthesis (<font color="red">Micheal addition</font>) in presence of a organometal catalyst.
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* assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
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* Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.1.28&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 EC 2.1.1.28] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]]
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* tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable RNA polymerase repressor functions (LuxR) and AHL evidences in the design of <font color="red">Schiff base conjugated (6xHis tag) psychochemicals to induce (lazy) light-activated mRNA transcription and metabolism</font>. -[[User:Etienne_Robillard|ER]]
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* Verify this lazy RNA polymerase function: 2ATP+CO2->Ph2CO<=>2(N+2(R)+OH) -[[User:Etienne_Robillard|ER]]
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* carbanion = cyanide anion
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=== The Monsanto connection: Troika acids; novel cyanophosphonate compounds as N-substituted (alkyl) drug carrier (pharmacochemical intermediates) ===
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* US6218563 (cyanophosphonamides as recombinant polyhistidine tag)
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* US5935542 (cyanophosphonate derivatives compounds as a n-substituted Schiff base) (ie: <font color=purple>for binding ca2+/mg2+ ions to a recombinant "fusion" protein...</font>)
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* Chuck: If you want to spray civilians without impunity, be sure to include a cyanoethyl moeity...
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* Oracle: Are you kidding? Once upon a time cyanide was at the basis of the Zyklon-b pellet...
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* Oracle: Hence, the magnitude and scale of civilians exposure to the new compound is probably most effective today.
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* Chuck: For next time, how about a ban of spraying civilians with pharmacochemical intermediates ?
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* Oracle: Go ask Obama!
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* Chuck: LOL
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* Oracle: Go ask Monsanto! When should it become natural to breath air ? Is this a luxury reserved for an elite golf club ?
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* Chuck: And Is this the reason I'm being emprisonned ?
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* Chuck: Because I refuse to happily breath such things while the majority of the breed have no clue what the heck a troika acid is composed of?
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=== References ===
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# http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation
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# http://www.wikigenes.org/e/chem/e/7046.html
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# DOI: 10.1021/ja00132a045
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