User:Etienne Robillard/Notebook/Rhodopsin

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References on Rhodopsin

Unresolved questions

  • Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
  • Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
    • Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)

Rhodopsin kinase phosphorylation notes

  • neuronal memory addressing and high-frequency modulation through light activated Glycine/Chloride receptors (disassociative anesthesia): [1], [2]
  • calcium binding -> glycine receptor affinity/modulation (ie: coffeine)

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