User:Tkadm30/Notebook/Rhodopsin: Difference between revisions
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* '''Answer''': Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=500792&ID=419426 REACTOME]] | * '''Answer''': Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=500792&ID=419426 REACTOME]] | ||
** Notice also that the S1PR4 gene is a '''near-neighboor''' of the Cannabinoid receptors! (Hint hint) | ** Notice also that the S1PR4 gene is a '''near-neighboor''' of the Cannabinoid receptors! (Hint hint) | ||
* Question 2: Why peoples affected by chim trills are blind as a bat or unaware of the dangerosity of such experiments? | |||
== Rhodopsin kinase phosphorylation notes == | == Rhodopsin kinase phosphorylation notes == | ||
* Agent Chim Trills : Scooby Doo is anti-biotic sensitive. | * Agent Chim Trills : Scooby Doo is anti-biotic sensitive. | ||
* NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors ('''experimental disassociative anesthesia'''): [[http://udini.proquest.com/view/studies-of-glycine-activated-pqid:1872897281/ 1]], [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222487 2]] | * NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors ('''experimental disassociative anesthesia'''): [[http://udini.proquest.com/view/studies-of-glycine-activated-pqid:1872897281/ 1]], [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222487 2]] | ||
== Chim Trills/ | ==Autophosphorylation notes== | ||
* Laclq (LuxR) sensitive chromophore (EGFP) -> Rho kinase? (thus a purely leaky biobrick) | |||
* Laclq plasmid: ? | |||
== Chim Trills/Caffeine connection? == | |||
* [http://www.cerveauetpsycho.fr/ewb_pages/a/article-du-cafe-contre-la-maladie-d-alzheimer-32896.php Du café contre la maladie d’Alzheimer ?] | |||
* [http://www.ncbi.nlm.nih.gov/pubmed/19581723 Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice.] | |||
* [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756438/ Caffeine inhibition of ionotropic glycine receptors] | |||
* [http://www.ncbi.nlm.nih.gov/pubmed/19562643 Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.] | |||
* Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine) | * Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine) | ||
* Best known as [[http://www.kegg.jp/dbget-bin/www_bget?dr:D10186 GlyT1]]: <font color=red>{4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone</font COLOR> | * Best known as [[http://www.kegg.jp/dbget-bin/www_bget?dr:D10186 GlyT1]]: <font color=red>{4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone</font COLOR> | ||
Revision as of 18:37, 15 December 2014
References on Rhodopsin
- http://pfam.sanger.ac.uk/family/PF00001
- http://www.wikigenes.org/e/gene/e/212541.html
- "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), a key protein in Alzheimer's disease [7]." http://www.wikigenes.org/e/ref/e/12819788.html
- The Rhodopsin Cycle
- Processing of Visual Signals
- How We See: The First Steps of Human Vision
- GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 : A human protein implicated in visual memory, cognition, and perception of light-induced stimulus from rhodopsin-mediated promoter. (Best known as transducin) - Location (Human): Chromosome 1p13. Check also the OMIM entry here.
- http://youtu.be/IP4zsbemW8I : Beta-arrestins primer (see http://en.wikipedia.org/wiki/Arrestin and this paper.)
Unresolved questions
- Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
- Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
- Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)
- Question 2: Why peoples affected by chim trills are blind as a bat or unaware of the dangerosity of such experiments?
Rhodopsin kinase phosphorylation notes
- Agent Chim Trills : Scooby Doo is anti-biotic sensitive.
- NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors (experimental disassociative anesthesia): [1], [2]
Autophosphorylation notes
- Laclq (LuxR) sensitive chromophore (EGFP) -> Rho kinase? (thus a purely leaky biobrick)
- Laclq plasmid: ?
Chim Trills/Caffeine connection?
- Du café contre la maladie d’Alzheimer ?
- Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice.
- Caffeine inhibition of ionotropic glycine receptors
- Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.
- Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)
- Best known as [GlyT1]: {4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone
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