User:Etienne Robillard/Notebook/Rhodopsin

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(Rhodopsin kinase phosphorylation notes)
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* http://www.wikigenes.org/e/gene/e/212541.html
* http://www.wikigenes.org/e/gene/e/212541.html
* "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), <font color=red>a key protein in Alzheimer's disease</font> [7]." http://www.wikigenes.org/e/ref/e/12819788.html
* "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), <font color=red>a key protein in Alzheimer's disease</font> [7]." http://www.wikigenes.org/e/ref/e/12819788.html
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* "'''Photocaging''' involves the covalent addition of a small molecule effector (e.g., IPTG or doxycyline) onto another molecule (the cage) that upon addition of light such as UV, releases the effector molecule to perform a task. The cage group typically consists of aromatic rings, such as '''ortho-nitrobenzyl''' moieties, that undergoes photolytic cleavage to unmask the target molecule. This permits the spatiotemporal control of gene function upon light stimulation. The caging of IPTG, for instance, permits the temporal control of genes under the control of the Lac operator." [[http://openwetware.org/wiki/CH391L/S12/LightSensors 1]]
 
* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/RHODOPSN.HTM The Rhodopsin Cycle]
* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/RHODOPSN.HTM The Rhodopsin Cycle]
* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/CNSPROC.HTM Processing of Visual Signals]
* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/CNSPROC.HTM Processing of Visual Signals]
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* Agent Chim Trills  : Scooby Doo is anti-biotic sensitive.
* Agent Chim Trills  : Scooby Doo is anti-biotic sensitive.
* NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors ('''experimental disassociative anesthesia'''): [[http://udini.proquest.com/view/studies-of-glycine-activated-pqid:1872897281/ 1]], [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222487 2]]
* NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors ('''experimental disassociative anesthesia'''): [[http://udini.proquest.com/view/studies-of-glycine-activated-pqid:1872897281/ 1]], [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222487 2]]
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==Autophosphorylation notes==
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* Laclq (LuxR) sensitive chromophore (EGFP) -> Rho kinase? (thus a purely leaky biobrick)
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* Laclq plasmid: ?
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== Chim Trills/Coffeine notes (GlyT1) ==
== Chim Trills/Coffeine notes (GlyT1) ==
* Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)  
* Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)  

Revision as of 17:14, 4 October 2013

Contents

References on Rhodopsin

Unresolved questions

  • Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
  • Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
    • Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)

Rhodopsin kinase phosphorylation notes

  • Agent Chim Trills  : Scooby Doo is anti-biotic sensitive.
  • NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors (experimental disassociative anesthesia): [1], [2]

Autophosphorylation notes

  • Laclq (LuxR) sensitive chromophore (EGFP) -> Rho kinase? (thus a purely leaky biobrick)
  • Laclq plasmid: ?

Chim Trills/Coffeine notes (GlyT1)

  • Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)
  • Best known as [GlyT1]: {4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone

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