User:Etienne Robillard/Notebook/Rhodopsin

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(Rhodopsin kinase phosphorylation notes)
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* http://pfam.sanger.ac.uk/family/PF00001
* http://pfam.sanger.ac.uk/family/PF00001
* http://www.wikigenes.org/e/gene/e/212541.html
* http://www.wikigenes.org/e/gene/e/212541.html
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* "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), a key protein in Alzheimer's disease [7]." http://www.wikigenes.org/e/ref/e/12819788.html
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* "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), <font color=red>a key protein in Alzheimer's disease</font> [7]." http://www.wikigenes.org/e/ref/e/12819788.html
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* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/RHODOPSN.HTM The Rhodopsin Cycle]
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* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/CNSPROC.HTM Processing of Visual Signals]
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* [http://www.accessexcellence.org/AE/AEC/CC/vision_background.php How We See: The First Steps of Human Vision]
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* [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2780 GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2] : A human protein implicated in visual memory, cognition, and perception of light-induced stimulus from rhodopsin-mediated promoter. (Best known as transducin) - Location (Human): Chromosome 1p13. Check also the OMIM entry [http://omim.org/entry/139340 here].
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* http://youtu.be/IP4zsbemW8I : Beta-arrestins primer (see http://en.wikipedia.org/wiki/Arrestin and this [http://www.ncbi.nlm.nih.gov/pubmed/15845844 paper].)
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== Unresolved questions ==
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* Question 1: In the expression "'''blind as a bat'''", is the bat blindness a permanent or temporary phenomenon and '''how''' could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
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* '''Answer''': Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=500792&ID=419426 REACTOME]]
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** Notice also that the S1PR4 gene is a '''near-neighboor''' of the Cannabinoid receptors! (Hint hint)
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== Rhodopsin kinase phosphorylation notes ==
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* Agent Chim Trills  : Scooby Doo is anti-biotic sensitive.
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* NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors ('''experimental disassociative anesthesia'''): [[http://udini.proquest.com/view/studies-of-glycine-activated-pqid:1872897281/ 1]], [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222487 2]]
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==Autophosphorylation notes==
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* Laclq (LuxR) sensitive chromophore (EGFP) -> Rho kinase? (thus a purely leaky biobrick)
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* Laclq plasmid: ?
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== Chim Trills/Coffeine notes (GlyT1) ==
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* Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)
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* Best known as [[http://www.kegg.jp/dbget-bin/www_bget?dr:D10186 GlyT1]]: <font color=red>{4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone</font COLOR> 
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----
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"Do the right thing. It will gratify some people and astonish the rest." - Mark Twain

Revision as of 17:14, 4 October 2013

Contents

References on Rhodopsin

Unresolved questions

  • Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
  • Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
    • Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)

Rhodopsin kinase phosphorylation notes

  • Agent Chim Trills  : Scooby Doo is anti-biotic sensitive.
  • NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors (experimental disassociative anesthesia): [1], [2]

Autophosphorylation notes

  • Laclq (LuxR) sensitive chromophore (EGFP) -> Rho kinase? (thus a purely leaky biobrick)
  • Laclq plasmid: ?

Chim Trills/Coffeine notes (GlyT1)

  • Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)
  • Best known as [GlyT1]: {4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone

"Do the right thing. It will gratify some people and astonish the rest." - Mark Twain

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