User:Etienne Robillard/Notebook/Rhodopsin

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(References on Rhodopsin)
(References on Rhodopsin)
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* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/CNSPROC.HTM Processing of Visual Signals]
* [http://www.vetmed.vt.edu/education/curriculum/vm8054/eye/CNSPROC.HTM Processing of Visual Signals]
* [http://www.accessexcellence.org/AE/AEC/CC/vision_background.php How We See: The First Steps of Human Vision]
* [http://www.accessexcellence.org/AE/AEC/CC/vision_background.php How We See: The First Steps of Human Vision]
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* [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2780 GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2] : A human protein implicated in visual memory, cognition, and perception of light-induced stimulus from rhodopsin-mediated promoter. (Best known as transducin)
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* [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2780 GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2] : A human protein implicated in visual memory, cognition, and perception of light-induced stimulus from rhodopsin-mediated promoter. (Best known as transducin) - Location (Human): Chromosome 1p13. Check also the OMIM entry [http://omim.org/entry/139340 here].
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* http://youtu.be/IP4zsbemW8I : Beta-arrestins primer (see http://en.wikipedia.org/wiki/Arrestin and this [http://www.ncbi.nlm.nih.gov/pubmed/15845844 paper].)
== Unresolved questions ==
== Unresolved questions ==
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* in the expression "'''blind as a bat'''", is the bat blindness a permanent or temporary phenomenon and could you explain how this is related to cGMP/ATP based phosphorylation of the Rho kinase?
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* Question 1: In the expression "'''blind as a bat'''", is the bat blindness a permanent or temporary phenomenon and '''how''' could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
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?
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* '''Answer''': Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [[http://www.reactome.org/entitylevelview/PathwayBrowser.html#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=500792&ID=419426 REACTOME]]
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** Notice also that the S1PR4 gene is a '''near-neighboor''' of the Cannabinoid receptors! (Hint hint)
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"Do the right thing. It will gratify some people and astonish the rest." - Mark Twain

Revision as of 06:06, 26 March 2013

References on Rhodopsin

Unresolved questions

  • Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
  • Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
    • Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)

"Do the right thing. It will gratify some people and astonish the rest." - Mark Twain

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