User:Tkadm30/Notebook/Rhodopsin
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References on Rhodopsin
- http://pfam.sanger.ac.uk/family/PF00001
- http://www.wikigenes.org/e/gene/e/212541.html
- "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), a key protein in Alzheimer's disease [7]." http://www.wikigenes.org/e/ref/e/12819788.html
- The Rhodopsin Cycle
- Processing of Visual Signals
- How We See: The First Steps of Human Vision
- GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 : A human protein implicated in visual memory, cognition, and perception of light-induced stimulus from rhodopsin-mediated promoter. (Best known as transducin) - Location (Human): Chromosome 1p13. Check also the OMIM entry here.
- http://youtu.be/IP4zsbemW8I : Beta-arrestins primer (see http://en.wikipedia.org/wiki/Arrestin and this paper.)
Unresolved questions
- Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
- Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
- Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)
- Question 2: Why peoples affected by chim trills are blind as a bat or unaware of the dangerosity of such experiments?
Rhodopsin kinase phosphorylation notes
- Agent Chim Trills : Scooby Doo is anti-biotic sensitive.
- NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors (experimental disassociative anesthesia): [1], [2]
Autophosphorylation notes
- Laclq (LuxR) sensitive chromophore (EGFP) -> Rho kinase? (thus a purely leaky biobrick)
- Laclq plasmid: ?
Chim Trills/Coffeine connection?
- Caffeine inhibition of ionotropic glycine receptors
- Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.
- Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)
- Best known as [GlyT1]: {4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone
"Do the right thing. It will gratify some people and astonish the rest." - Mark Twain
