User:Tkadm30/Notebook/Paliperidone/2013/10/10

9-hydroxyrisperidone degradation and racemization

From PLP substrate: The road to PMP

1. Goal: Transamination of 9-OH to inactivated PLP racemase
2. Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP.
3. Notebooks:
   1. Part 1: PLP biosynthesis from 9-hydroxyrisperidone metabolite
4. CYP2D6: Metabolite degradation, liver enzymes (NADPH?),
   1. http://dmd.aspetjournals.org/content/29/10/1263.full
   2. Establish role of Aldehyde oxidase in paliperidone metabolite degradation
5. ATP hydrolysis:
   1. Enzyme assisted metabolite racemization (serine racemase): Uniprot
      1. Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.")
6. keywords: TCA

See also

OPH Notebook