User:Tkadm30/Notebook/Paliperidone/2013/10/10: Difference between revisions

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== 9-OH (risperidone) degradation scrachpad==
__TOC__


* Todo:  
== 9-hydroxyrisperidone degradation and racemization ==
# Investigate CYP2D6  
 
# Establish Role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
=== From PLP substrate: The road to PMP ===
# Confirm degradation of metabolite vs no inhibitor (as for [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|PLP biosynthesis from 9-oh risperidone]]...)
 
# Study (Mg+ATP) hydrolisis further
#Goal: Transamination of 9-OH to inactivated PLP racemase
## include notes about AU-bound metal catalysts, OPH ''''hydrolase''' (AuNP hydrosols)
#Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP.
#Notebooks:
## [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|Part 1: PLP biosynthesis from 9-hydroxyrisperidone metabolite]]
# CYP2D6: Metabolite degradation, liver enzymes (NADPH?),
## http://dmd.aspetjournals.org/content/29/10/1263.full
## Establish role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
# ATP hydrolysis:
## Enzyme assisted metabolite racemization (serine racemase): [http://www.uniprot.org/uniprot/Q9GZT4 Uniprot]  
### Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.")
#keywords: TCA
 
==See also==
[[User:Etienne_Robillard/Notebook/OPH|OPH Notebook]]

Revision as of 06:15, 6 December 2013

9-hydroxyrisperidone degradation and racemization

From PLP substrate: The road to PMP

  1. Goal: Transamination of 9-OH to inactivated PLP racemase
  2. Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP.
  3. Notebooks:
    1. Part 1: PLP biosynthesis from 9-hydroxyrisperidone metabolite
  4. CYP2D6: Metabolite degradation, liver enzymes (NADPH?),
    1. http://dmd.aspetjournals.org/content/29/10/1263.full
    2. Establish role of Aldehyde oxidase in paliperidone metabolite degradation
  5. ATP hydrolysis:
    1. Enzyme assisted metabolite racemization (serine racemase): Uniprot
      1. Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.")
  6. keywords: TCA

See also

OPH Notebook

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