User:Etienne Robillard/Notebook/Paliperidone/2013/10/10

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(9-OH (risperidone) degradation scrachpad)
Current revision (09:15, 6 December 2013) (view source)
(From PLP substrate: The road to PMP)
 
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== 9-OH (risperidone) degradation scrachpad==
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__TOC__
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* Todo:  
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== 9-hydroxyrisperidone degradation and racemization ==
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# Investigate CYP2D6  
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# Establish Role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
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=== From PLP substrate: The road to PMP ===
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# Confirm degradation of metabolite vs no inhibitor (as for [[User:Etienne_Robillard/Notebook/2013/06/21|PLP biosynthesis]]...)
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# Study (Mg+ATP) hydrolisis further
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#Goal: Transamination of 9-OH to inactivated PLP racemase
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## include notes about AU-bound metal catalysts, OPH ''''hydrolase''' (AuNP hydrosols)
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#Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP.
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#Notebooks:
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## [[User:Etienne_Robillard/Notebook/Paliperidone/2013/06/21|Part 1: PLP biosynthesis from 9-hydroxyrisperidone metabolite]]
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# CYP2D6: Metabolite degradation, liver enzymes (NADPH?),
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## http://dmd.aspetjournals.org/content/29/10/1263.full
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## Establish role of [http://www.uniprot.org/uniprot/Q06278 Aldehyde oxidase] in paliperidone metabolite degradation
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# ATP hydrolysis:
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## Enzyme assisted metabolite racemization (serine racemase): [http://www.uniprot.org/uniprot/Q9GZT4 Uniprot]  
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### Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.")
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#keywords: TCA
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==See also==
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[[User:Etienne_Robillard/Notebook/OPH|OPH Notebook]]

Current revision

Contents


9-hydroxyrisperidone degradation and racemization

From PLP substrate: The road to PMP

  1. Goal: Transamination of 9-OH to inactivated PLP racemase
  2. Method: Racemization of optically-active metabolite to produce pyridoxal phosphate as a Schiff base/intermediate to PMP.
  3. Notebooks:
    1. Part 1: PLP biosynthesis from 9-hydroxyrisperidone metabolite
  4. CYP2D6: Metabolite degradation, liver enzymes (NADPH?),
    1. http://dmd.aspetjournals.org/content/29/10/1263.full
    2. Establish role of Aldehyde oxidase in paliperidone metabolite degradation
  5. ATP hydrolysis:
    1. Enzyme assisted metabolite racemization (serine racemase): Uniprot
      1. Note: "Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP. Competitively inhibited by malonate.")
  6. keywords: TCA

See also

OPH Notebook

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