User:Etienne Robillard/Notebook/Paliperidone/2013/06/21

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** pathway (Citrate cycle): http://www.kegg.jp/kegg-bin/show_pathway?ec00020+1.1.1.41
** pathway (Citrate cycle): http://www.kegg.jp/kegg-bin/show_pathway?ec00020+1.1.1.41
* [http://pathman.smpdb.ca/pathways/SMP00033/pathway Methionine Metabolism]
* [http://pathman.smpdb.ca/pathways/SMP00033/pathway Methionine Metabolism]
 +
* [http://en.wikipedia.org/wiki/Beta-glucuronidase Wikipedia:Beta-glucuronidase] (ec 3.2.1.31)
===References===
===References===
# [http://dmd.aspetjournals.org/content/36/4/769.full Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans]
# [http://dmd.aspetjournals.org/content/36/4/769.full Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans]
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# [http://en.wikipedia.org/wiki/Beta-glucuronidase Wikipedia page on Beta-glucuronidase] (ec 3.2.1.31)
 
# [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321271/ The Oxidative Stress May be Induced by the Elevated Homocysteine in Schizophrenic Patients]
# [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321271/ The Oxidative Stress May be Induced by the Elevated Homocysteine in Schizophrenic Patients]

Revision as of 22:32, 27 August 2013

Contents

Synopsis

So you have been forced by a foolish human-android to acknowledge the insanity of this so-called society ? Don't worry, bud, we'll work something out as always :)

Objectives

The purposes and aims of this experiment are two folds: First, we want you to avoid being mentally harmed while being forced to take antipsychotics drugs. Second, we want you to find a way to functionalize the degradation of the psychoactive compound into a non-psychoactive, and safe racemase.

Design philosophy

  • broad spectrum specificity : The degradation of the optically-active racemate must accept many substrates. (ie: pines and dones)
  • Fast, safe, and side-effects free bioremoval of the metabolite.

One Step Transamination and Degradation of Paliperidone to PLP

  • Approach 1: racemization of paliperidone to 5'-pyridoxal phosphate (PLP) via MTRR(ATP) synthase, a B-glucuronide (B-galactosidase) analog. This is an experimental method to neutralize the active metabolite to a more safe mono-aminase, which should hopefully provide a wet blanket for glutamate-induced neurotoxicity.

Starting Material

  • paliperidone: an atypical antipsychotic derived from Risperidone. see Risperidone.
  • clozanpine: another atypical antipsychotic
  • citric acid : refer to "Citric acid cycle"

Glossary

  • racemate:
  • racemase:
  • racemization:
  • ketoacidosis:
  • reagent:
  • methylation:
  • glucoronide:
  • amide:
  • ester:
  • transaminase:
  • transaldimination:
  • palmitate: Salt/ester of palmitic acid - a saturated fatty acid (reference: wikipedia)

Notes

References

  1. Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans
  2. The Oxidative Stress May be Induced by the Elevated Homocysteine in Schizophrenic Patients

Did you know?

The secret of education lies in respecting the pupil. - Ralph Waldo Emerson
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