User:Etienne Robillard/Notebook/Paliperidone/2013/06/21

From OpenWetWare

< User:Etienne Robillard | Notebook | Paliperidone(Difference between revisions)
Jump to: navigation, search
(ā†’References)
Current revision (22:48, 6 October 2013) (view source)
(ā†’Starting Material)
 
Line 17: Line 17:
* paliperidone: an atypical antipsychotic derived from Risperidone. see [[User:Etienne_Robillard/Notebook/Risperidone|Risperidone]].
* paliperidone: an atypical antipsychotic derived from Risperidone. see [[User:Etienne_Robillard/Notebook/Risperidone|Risperidone]].
-
* clozanpine: another atypical antipsychotic
+
* isocitrate (citric acid precursor) : refer to "Citric acid cycle" (ascorbic acid)
-
* citric acid : refer to "Citric acid cycle"  
+
* delta9-tetrahydrocannabinol : competitive GABA antagonist (inhibitor)
 +
* l-methionine: from eggs (ie: 1 full egg)
 +
 
===Glossary===
===Glossary===

Current revision

Contents

Synopsis

So you have been forced by a foolish human-android to acknowledge the insanity of this so-called society ? Don't worry, bud, we'll work something out as always :)

Objectives

The purposes and aims of this experiment are two folds: First, we want you to avoid being mentally harmed while being forced to take antipsychotics drugs. Second, we want you to find a way to functionalize the degradation of the psychoactive compound into a non-psychoactive, and safe racemase.

Design philosophy

  • broad spectrum specificity : The degradation of the optically-active racemate must accept many substrates. (ie: pines and dones)
  • Fast, safe, and side-effects free bioremoval of the metabolite.

One Step Transamination and Degradation of Paliperidone to PLP

  • Approach 1: racemization of paliperidone to 5'-pyridoxal phosphate (PLP) via MTRR(ATP) synthase, a B-glucuronide (B-galactosidase) analog. This is an experimental method to neutralize the active metabolite to a more safe mono-aminase, which should hopefully provide a wet blanket for glutamate-induced neurotoxicity.

Starting Material

  • paliperidone: an atypical antipsychotic derived from Risperidone. see Risperidone.
  • isocitrate (citric acid precursor) : refer to "Citric acid cycle" (ascorbic acid)
  • delta9-tetrahydrocannabinol : competitive GABA antagonist (inhibitor)
  • l-methionine: from eggs (ie: 1 full egg)

Glossary

  • racemate:
  • racemase:
  • racemization: "The production of a racemate from a chiral starting material in which one enantiomer is present in excess." (see Racemate)
  • ketoacidosis:
  • reagent:
  • methylation:
  • glucuronide:
  • amide:
  • ester:
  • transaminase:
  • transaldimination:
  • palmitate: Salt/ester of palmitic acid - a saturated fatty acid (reference: wikipedia)

Notes

References

  1. Absorption, Metabolism, and Excretion of Paliperidone, a New Monoaminergic Antagonist, in Humans
  2. The Oxidative Stress May be Induced by the Elevated Homocysteine in Schizophrenic Patients
  3. The Pharmacological Role and Clinical Applications of Antipsychoticsā€™ Active Metabolites: Paliperidone versus Risperidone

Did you know?

The secret of education lies in respecting the pupil. - Ralph Waldo Emerson
Personal tools