User:Etienne Robillard/Notebook/NMDA dependent cell adhesion

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Mo calcium, mo visual hallucinations



An essay on the role of the Integrin beta-3 protein (ITGB3) in Ca2+-dependent orthogonal riboswitches.


In the study of calcium-mediated (Ca2+) neuronal receptors (NMDA and GABA mostly), the relevance of Ca2+-dependent ligands (ie: calmodulin) may hold important factors in the morphogenesis of psychological brain disorders and the pathogenesis of the Alzheimer disease, a important phenotype in the understanding of GPCR-mediated brain mutations. Hence a proper understanding of the polypyrimidine tract binding protein-1 (PTBP1) dependent signaling pathway may reveal new insights in the functions and features of the integrin beta-3 protein as a cell-adhesive (and voltage-gated!) neural substrate for long-term axon and neuronal growth. [1]


  • A integrin beta3 mutant polypeptide lacking the PTBP1 gene ?


  4. ITGB2
  5. OMIM (ITGB2): (note the chromosome location and the annotated phenotype)


  • Integrins, pyrimidine, glutamine, NMDA, hippocampus, calmodulin, PTBP1

For next time!

  • Review and complete wiki class page on Integrase.
  • Review Calcium and GABA signaling? (Hint: Wet blanket for Calcium-mediated glutamine endotoxicity!)
  • beta-amyloids APP - In the synthesis of 1,2,3,4-tetrahydroisoquinolines derivatives via asymmetric PS synthesis, how is beta-linked amyloids (note: For the Alzheimer precursor protein type "APP" on uniprot) responding to 2.45 GHz electromagnetic waves (2.450 GHz is a typical radio-frequency (RF) signal used in portable human wireless devices; Iphone4-type device; etc) for horn-directed mutagenesis of neuronal X-linked polypeptides/ligands ?
  • Moreover assuming the psychochemical media require a ultra-sound frequency (ie: 2.450 GHz) to INDUCE mRNA-activated polypeptide alkane isomerisation of the PTBP1 genes, how mentally retarded do you estimate a human-made decision must be (IQ) to allow and implement the forced installation of such biological assault devices without the consent and informed judgement into the homes and residences of civilians ?

See also...

  • Rhodopsin - Rho/GTPase specific AI inducers: Rhodopsin etc.
  • c-Src specialized kinase (SH2/SH3 domain, PH domain, etc)
  • MAPK <-> c-Src domain interactions and cross-talk, ie integrins mediated cross-talking, see also EGFR
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