User:Etienne Robillard/Notebook/Methylphenidate/2013/06/15

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(Chim trills at a glance: The reality of science is mathematically founded.)
Current revision (05:50, 26 July 2013) (view source)
(Chim trills at a glance: The reality of science is mathematically founded.)
 
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=== Chim trills at a glance: The reality of science is mathematically founded. ===
=== Chim trills at a glance: The reality of science is mathematically founded. ===
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* Reaction: Claisen Condensation (Michael addition)  
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* Reaction: Claisen-type Condensation (Michael addition) (confirm)
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* Chemical (Reagent): 1 (Dudley reagent)
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* Chemical (Reagent): 2 (Dudley reagent/PMB), DMSO or DMF (confirm) 
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* Phases: 1  
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* Phases: 1 (confirm)
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* Chemical (solvent): Benzylamine-like cyclohexane (Heterocyclics; NHC)
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* Chemical (solvent): Benzylamine-like cyclohexane (Heterocyclics; NHC) (confirm)
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* Catalyst: Isonitrile (0.01 probability)  
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* Catalyst: Isonitrile (0.01 probability/confirm)  
** Why: reaction must occur with weak (neutral) base and in presence of a branched alcohol (benzaldehyde?) or toluene
** Why: reaction must occur with weak (neutral) base and in presence of a branched alcohol (benzaldehyde?) or toluene
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* Note 1: A reductive alkylation with a ortho phenyl ester (triethyl orthoformate?)  
+
* Note 1: A reductive alkylation with a ortho phenyl ester (triethyl orthoformate?) (confirm)
* Note 2: This probably indicate (p=0.01) the presence of a synthetic reagent to catalyze the isonitrile base into a compound identified as a active methylene '''enolate''' or more specifically methylphenidate hcl, a potent amphetamine-based dopamine inhibitor and GABA antagonist.  
* Note 2: This probably indicate (p=0.01) the presence of a synthetic reagent to catalyze the isonitrile base into a compound identified as a active methylene '''enolate''' or more specifically methylphenidate hcl, a potent amphetamine-based dopamine inhibitor and GABA antagonist.  
* Related reactions: Ugi reaction, [http://www.mhhe.com/physsci/chemistry/carey/student/olc/graphics/carey04oc/ref/ch21enolatereactions.html#dieckmann Dieckmann Condensation], Suzuki coupling (Pictet Spengler)
* Related reactions: Ugi reaction, [http://www.mhhe.com/physsci/chemistry/carey/student/olc/graphics/carey04oc/ref/ch21enolatereactions.html#dieckmann Dieckmann Condensation], Suzuki coupling (Pictet Spengler)
* Starting materials: benzaldehyde (7c?), benzoyl acid (Chuck), trichloroisocyanuric acid (HCl?), THF
* Starting materials: benzaldehyde (7c?), benzoyl acid (Chuck), trichloroisocyanuric acid (HCl?), THF
* Related compounds: [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]], [[User:Etienne_Robillard/Notebook/Methylphenidate|Methylphenidate (Ritalin)]], 1,2,3,4-tetrahydroisoquinoline (mefloquine), benzylamine (benzoxadiazole), Agent Buzz (15), [[User:Etienne_Robillard/Notebook/30C6HSL|30C6HSL]]
* Related compounds: [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]], [[User:Etienne_Robillard/Notebook/Methylphenidate|Methylphenidate (Ritalin)]], 1,2,3,4-tetrahydroisoquinoline (mefloquine), benzylamine (benzoxadiazole), Agent Buzz (15), [[User:Etienne_Robillard/Notebook/30C6HSL|30C6HSL]]
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* Target receptors: NMDA1R, S1PR4, GABA, Dopamine, Serotonin, MAPK, EGFR
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* Target receptors: NMDA1R ('''antagonist'''), S1PR4 (confirm), GABA, Dopamine, Serotonin, MAPK, EGFR
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* Primary phenotype: Alzheimer ?
+
* Primary phenotype: Alzheimer/Dementia (confirm)
* Secondary phenotypes: Alcoholism, Parkinson, Breast Cancer
* Secondary phenotypes: Alcoholism, Parkinson, Breast Cancer
* Probable method of one-pot/multi-step synthesis: Microwave-activated RF synthesis (Fmoc/carboxilic deprotection)
* Probable method of one-pot/multi-step synthesis: Microwave-activated RF synthesis (Fmoc/carboxilic deprotection)

Current revision

MW induced active methylene enolate synthesis

Lazy, untested protocol for remotely-triggered blue cheese (amphetamine-induced) psychosis.

What we know so far: The bliss of ignorance is deeper in the region of tyranny.

For remote activation of active formamide (methyl-ene) enolate reduction using electromagnetic heat of branched alcohols: see Acetaldehyde: A sort of (aryl conjugated) ethanolamine but this is controversial. :)

Chim trills at a glance: The reality of science is mathematically founded.

  • Reaction: Claisen-type Condensation (Michael addition) (confirm)
  • Chemical (Reagent): 2 (Dudley reagent/PMB), DMSO or DMF (confirm)
  • Phases: 1 (confirm)
  • Chemical (solvent): Benzylamine-like cyclohexane (Heterocyclics; NHC) (confirm)
  • Catalyst: Isonitrile (0.01 probability/confirm)
    • Why: reaction must occur with weak (neutral) base and in presence of a branched alcohol (benzaldehyde?) or toluene
  • Note 1: A reductive alkylation with a ortho phenyl ester (triethyl orthoformate?) (confirm)
  • Note 2: This probably indicate (p=0.01) the presence of a synthetic reagent to catalyze the isonitrile base into a compound identified as a active methylene enolate or more specifically methylphenidate hcl, a potent amphetamine-based dopamine inhibitor and GABA antagonist.
  • Related reactions: Ugi reaction, Dieckmann Condensation, Suzuki coupling (Pictet Spengler)
  • Starting materials: benzaldehyde (7c?), benzoyl acid (Chuck), trichloroisocyanuric acid (HCl?), THF
  • Related compounds: Arylcyclohexylamines, Methylphenidate (Ritalin), 1,2,3,4-tetrahydroisoquinoline (mefloquine), benzylamine (benzoxadiazole), Agent Buzz (15), 30C6HSL
  • Target receptors: NMDA1R (antagonist), S1PR4 (confirm), GABA, Dopamine, Serotonin, MAPK, EGFR
  • Primary phenotype: Alzheimer/Dementia (confirm)
  • Secondary phenotypes: Alcoholism, Parkinson, Breast Cancer
  • Probable method of one-pot/multi-step synthesis: Microwave-activated RF synthesis (Fmoc/carboxilic deprotection)
  • Reaction type: Organic synthesis

See also

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