User:Etienne Robillard/Notebook/Methylphenidate

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(Have a happy 5th of july :))
(Microwave/DMF activated N-benzylformamide catalysis of (R,R')-(+)-methylphenidate)
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Cycloalkane -> [[User:Etienne_Robillard/Notebook/Schiff_base|Schiff base]] -> benzylamine protected enantiomer (ie: methylphenidate...)
Cycloalkane -> [[User:Etienne_Robillard/Notebook/Schiff_base|Schiff base]] -> benzylamine protected enantiomer (ie: methylphenidate...)
-
=== Microwave (RF) activated N-benzylformamide catalysis of 1,2-methylphenidate ===
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=== Microwave/DMF activated N-benzylformamide catalysis of (R,R')-(+)-methylphenidate ===
* 130605:  
* 130605:  
** doi: 10.1073/pnas.1005399107  
** doi: 10.1073/pnas.1005399107  
** until the 5th of july is over, you may want to review the [http://www.kegg.jp/dbget-bin/www_bget?pathway+map00360 Shikimate pathway] :)
** until the 5th of july is over, you may want to review the [http://www.kegg.jp/dbget-bin/www_bget?pathway+map00360 Shikimate pathway] :)
 +
** lovely: ritalin synthesis with bacterial promoters: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033428/

Revision as of 22:29, 5 July 2013

http://chemwiki.ucdavis.edu/Organic_Chemistry/Hydrocarbons/Alkanes/Nomenclature_of_Cycloalkanes

The Acetoacetic Ester Condensation (Claisen Condensation...)

United States Patent 8283472

http://en.wikipedia.org/wiki/Triethyl_orthoformate (note the cyanide mention at the top of the page...)

FRIEDEL-CRAFT acylation: http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch12/ch12-7.html

4-methylimidazole (4-Mel) -> 4-acylaminopyridine derivative: US7998971

Construction of optically active (4-trans) methylphenidate hcl derivatives ! http://www.seattlepi.com/news/article/Group-finds-carcinogen-in-Pepsi-outside-Calif-4644602.php

GSK-3: glycogen synthase kinase 3 (inhibitor)


Never give up, never surrender

Cycloalkane -> Schiff base -> benzylamine protected enantiomer (ie: methylphenidate...)

Microwave/DMF activated N-benzylformamide catalysis of (R,R')-(+)-methylphenidate

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