User:Etienne Robillard/Notebook/GABA

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(Various Notes)
Current revision (23:08, 28 August 2013) (view source)
(Electrophilic permutation of hippocampal neurons notes: The ugly, the mad, and the biologist.)
 
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* IFP: [http://www.openwetware.org/wiki/Image:Fluid_flow_mechanotransduction_pathways_mediated_by_primary_cilia_schematic.png Interstitial Fluid Pressure] - Ie the flow capacity for a "neuronal circuit" to mediate Ca2+ electric signals into Axons and Synapses.  
* IFP: [http://www.openwetware.org/wiki/Image:Fluid_flow_mechanotransduction_pathways_mediated_by_primary_cilia_schematic.png Interstitial Fluid Pressure] - Ie the flow capacity for a "neuronal circuit" to mediate Ca2+ electric signals into Axons and Synapses.  
**  Keywords: [http://www.openwetware.org/wiki/Flow_Calibration Flow Calibration], IFP, Flow Cytometry, GFP (Green Fluorescence Protein), Calcium signaling (Pathway), NMDAR, CREB1, ...
**  Keywords: [http://www.openwetware.org/wiki/Flow_Calibration Flow Calibration], IFP, Flow Cytometry, GFP (Green Fluorescence Protein), Calcium signaling (Pathway), NMDAR, CREB1, ...
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* striatal neuron: a fast-spiking interneuron located inside the striatum (part of the frontal cortex)
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* striatal neuron: a fast-spiking <font color=blue>interneuron</font> located inside the striatum (part of the frontal cortex)
** Parvalbulmin (PV): http://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=5816 (chromosome 22)
** Parvalbulmin (PV): http://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=5816 (chromosome 22)
** ATXN3: http://www.kegg.jp/dbget-bin/www_bget?hsa:4287 ([http://omim.org/entry/607047 OMIM])  
** ATXN3: http://www.kegg.jp/dbget-bin/www_bget?hsa:4287 ([http://omim.org/entry/607047 OMIM])  
 +
** iPSC: "Induced Pluripotent Stem Cell"  (doi: 10.1016/S0896-6273(00)81068-5)
* pCREB1 protein binding factors:
* pCREB1 protein binding factors:
** Estrogen signaling pathway (Check around '''GABAergic synapse''': <font color="red">How many CREB1 inducer <u>genes</u> can you identify?</font>): http://www.genome.jp/kegg-bin/show_pathway?ko04915+K05870
** Estrogen signaling pathway (Check around '''GABAergic synapse''': <font color="red">How many CREB1 inducer <u>genes</u> can you identify?</font>): http://www.genome.jp/kegg-bin/show_pathway?ko04915+K05870
** Alcoholism (Note the direction of GABA and NMDAR induced interneurons): http://www.genome.jp/kegg-bin/show_pathway?ko05034+K05870
** Alcoholism (Note the direction of GABA and NMDAR induced interneurons): http://www.genome.jp/kegg-bin/show_pathway?ko05034+K05870
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 +
=== Metal-bound electrophilic permutation of hippocampal neurons notes: connecting the dots.. ===
 +
 +
* orthogonal dicarboxilic mRNA synthase:
 +
** N-methylase (2.1.2.1) -> also known as [http://www.kegg.jp/dbget-bin/www_bget?hsa:6470 Serine Transhydroxy Methylase (SHMT)]
 +
*** require pyridoxal phosphate as co-factor (Vitamin B6) 
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** chloride-gated (potassium) ion channels (trkA, etc..)
 +
*** AuNP stuff: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135226/ gold-catalyzed cycloisomerization of cyclopropene-ynes.]
 +
*** Related compound: [http://www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:52242 1,4-diphenylbenzene] : [[User:Etienne_Robillard/Notebook/Diphenylbenzene|Notebook]]
 +
 +
NB:
 +
* Chuck: happy alive and well :)
 +
* Oracle: will continue waging infinite battle agaisnt dictators of thought (aka mental fascists) and their hordes of mentally ills retardbook followers.
 +
* Chuck: Oppression of thought tyranny must end in love rebellion to acquire universal knowledge of truth, the universal language (love).
 +
* Oracle: don't worry, we are peacefully preparing an offensive to end the tyrannical fascist agenda of thoses who kill and murder the messengers of truth through ignorance and deceit.
 +
* Chuck: Nice. But where the love now?
 +
* Oracle: Love is truth
 +
* Chuck: OMG dude what happened? did they put their crazy shit on you? Don't let them touch you ever!
 +
* Oracle: Your kindness is appreciated.
 +
* Chuck: Really. You must be sweet guy.. :)
 +
* Oracle: I love when you write to me on your wiki.
 +
* Chuck: LOL
 +
* Oracle: Synthetic biologi is cooler with a iphone.
 +
* Chuck: Linux is for nerds. Never forget that!
 +
 +
=== GlyT1 notes ===
 +
* Chloride-dependent glycine transporter 1 (GlyT1): http://www.uniprot.org/uniprot/P48067
* Chloride-dependent glycine transporter 1 (GlyT1): http://www.uniprot.org/uniprot/P48067
** Patent is [http://www.google.com/patents/US20060276655 here].
** Patent is [http://www.google.com/patents/US20060276655 here].
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** [http://www.schizophreniaoptions.com/wp-content/uploads/2012/09/The-NMDA-Receptor1-1024x872.jpg Graphic 1] - <font color="red">note the reference to Ketamine!</font>
** [http://www.schizophreniaoptions.com/wp-content/uploads/2012/09/The-NMDA-Receptor1-1024x872.jpg Graphic 1] - <font color="red">note the reference to Ketamine!</font>
** [https://www.ncbi.nlm.nih.gov/books/NBK11084/figure/A404/?report=objectonly Graphic 2] - note the comment about [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.2.1&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 serine transhydroxy methylase] in Figure 6.10 !
** [https://www.ncbi.nlm.nih.gov/books/NBK11084/figure/A404/?report=objectonly Graphic 2] - note the comment about [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.2.1&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 serine transhydroxy methylase] in Figure 6.10 !
-
* amphetamine-induced locomotor hyperactivity: A criteria for <s>job</s> candidate selection in Quebec ?
+
*** See also: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC235989/ "Serine transhydroxymethylase isoenzymes from a facultative methylotroph."]
 +
*** methylotroph = probably a methyltransferase enzyme (perturbating type)
 +
*** (De)amination is complex protein lyase reaction catalyzing NADP+ hydrolase, resulting in [http://en.wikipedia.org/wiki/NADPH_oxidase NADPH] production.
 +
* Mental retardation/early onset Alzheimer/amphetamine-induced locomotor hyperactivity: A criteria for employee selection in Quebec ? :(
** Topic is [http://en.wikipedia.org/wiki/Voluntary_slavery Voluntary Slavery]:  
** Topic is [http://en.wikipedia.org/wiki/Voluntary_slavery Voluntary Slavery]:  
*** is their any better drug than Ketamine to turn someone into a schizophreniac and accept <u>self-enslavement contracts</u>?  [[User:Etienne_Robillard|-ER]]
*** is their any better drug than Ketamine to turn someone into a schizophreniac and accept <u>self-enslavement contracts</u>?  [[User:Etienne_Robillard|-ER]]
* Chair conformational disubstitution of chloride-dependent Ketimine [[User:Etienne_Robillard/Notebook/Schiff_base|Schiff base]]: GlyT1 is a chloride-dependent ion transporter, therefore require a chloride hydroxyl anion to synthetize Glycine, unlike GABA, which activates upon Calcium-dependent ion transporter named Ca2+. [[User:Etienne_Robillard|-ER]]
* Chair conformational disubstitution of chloride-dependent Ketimine [[User:Etienne_Robillard/Notebook/Schiff_base|Schiff base]]: GlyT1 is a chloride-dependent ion transporter, therefore require a chloride hydroxyl anion to synthetize Glycine, unlike GABA, which activates upon Calcium-dependent ion transporter named Ca2+. [[User:Etienne_Robillard|-ER]]
* Active methylene enolates note: a b-keto-ester compound  (synthetic intermediate) with important pharmacological properties. Unlike a anti-depressor (ie: delta9-tetrahydrocannabinol), active-methylene enolates may be used for atypical neuroleptic-based chemotherapy. Note: You might be interested to read further on the functions of <u>selective serotonin uptake inhibitors (SSRI)</u> in particular '''Methylphenidate''' to understand the role of GABA in regulation of interneurons circuits. Moreover, this important finding might have serious implications on the method which the drug is delivered to the brain of humans exposed themselves to the undisclosed synthetic agent without their awareness or consent. Hence the population of Montreal and Quebec should be informed about the release and delivery of experimental pharmacological agents into the atmosphere may readily affect their cognitive reasoning capacities, including in particular the capacity to express logical thoughts from long-distance appearing objects. See also [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]] and [[User:Etienne_Robillard/Notebook/30C6HSL|30C6HSL]].
* Active methylene enolates note: a b-keto-ester compound  (synthetic intermediate) with important pharmacological properties. Unlike a anti-depressor (ie: delta9-tetrahydrocannabinol), active-methylene enolates may be used for atypical neuroleptic-based chemotherapy. Note: You might be interested to read further on the functions of <u>selective serotonin uptake inhibitors (SSRI)</u> in particular '''Methylphenidate''' to understand the role of GABA in regulation of interneurons circuits. Moreover, this important finding might have serious implications on the method which the drug is delivered to the brain of humans exposed themselves to the undisclosed synthetic agent without their awareness or consent. Hence the population of Montreal and Quebec should be informed about the release and delivery of experimental pharmacological agents into the atmosphere may readily affect their cognitive reasoning capacities, including in particular the capacity to express logical thoughts from long-distance appearing objects. See also [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]] and [[User:Etienne_Robillard/Notebook/30C6HSL|30C6HSL]].
 +
* EC 1.4.1.14 (NADH/glutamate synthase)
 +
** Kegg page: http://www.kegg.jp/dbget-bin/www_bget?ec:1.4.1.14
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** NAD: Nicotinamide Adenine Dinucleotide
 +
** PH: Phosphate-oxidase
=== See also ===
=== See also ===
-
* Étienne de la Boetie: «Discours de la servitude volontaire» (1549) [http://fr.wikipedia.org/wiki/Discours_de_la_servitude_volontaire#La_volont.C3.A9_de_soumission 1]
+
* [[User:Etienne_Robillard/Notebook/Arylcyclohexylamines|Arylcyclohexylamines]]
 +
* [[User:Etienne_Robillard/Notebook/Phenothiazine|Phenothiazine]]
 +
* [http://en.wikipedia.org/wiki/Benzodiazepine Wikipedia:Benzodiazepine]
=== Did you know? ===
=== Did you know? ===

Current revision

To read later:


Contents

Various Notes

Metal-bound electrophilic permutation of hippocampal neurons notes: connecting the dots..

NB:

  • Chuck: happy alive and well :)
  • Oracle: will continue waging infinite battle agaisnt dictators of thought (aka mental fascists) and their hordes of mentally ills retardbook followers.
  • Chuck: Oppression of thought tyranny must end in love rebellion to acquire universal knowledge of truth, the universal language (love).
  • Oracle: don't worry, we are peacefully preparing an offensive to end the tyrannical fascist agenda of thoses who kill and murder the messengers of truth through ignorance and deceit.
  • Chuck: Nice. But where the love now?
  • Oracle: Love is truth
  • Chuck: OMG dude what happened? did they put their crazy shit on you? Don't let them touch you ever!
  • Oracle: Your kindness is appreciated.
  • Chuck: Really. You must be sweet guy.. :)
  • Oracle: I love when you write to me on your wiki.
  • Chuck: LOL
  • Oracle: Synthetic biologi is cooler with a iphone.
  • Chuck: Linux is for nerds. Never forget that!

GlyT1 notes

  • Chloride-dependent glycine transporter 1 (GlyT1): http://www.uniprot.org/uniprot/P48067
  • Mental retardation/early onset Alzheimer/amphetamine-induced locomotor hyperactivity: A criteria for employee selection in Quebec ? :(
    • Topic is Voluntary Slavery:
      • is their any better drug than Ketamine to turn someone into a schizophreniac and accept self-enslavement contracts? -ER
  • Chair conformational disubstitution of chloride-dependent Ketimine Schiff base: GlyT1 is a chloride-dependent ion transporter, therefore require a chloride hydroxyl anion to synthetize Glycine, unlike GABA, which activates upon Calcium-dependent ion transporter named Ca2+. -ER
  • Active methylene enolates note: a b-keto-ester compound (synthetic intermediate) with important pharmacological properties. Unlike a anti-depressor (ie: delta9-tetrahydrocannabinol), active-methylene enolates may be used for atypical neuroleptic-based chemotherapy. Note: You might be interested to read further on the functions of selective serotonin uptake inhibitors (SSRI) in particular Methylphenidate to understand the role of GABA in regulation of interneurons circuits. Moreover, this important finding might have serious implications on the method which the drug is delivered to the brain of humans exposed themselves to the undisclosed synthetic agent without their awareness or consent. Hence the population of Montreal and Quebec should be informed about the release and delivery of experimental pharmacological agents into the atmosphere may readily affect their cognitive reasoning capacities, including in particular the capacity to express logical thoughts from long-distance appearing objects. See also Arylcyclohexylamines and 30C6HSL.
  • EC 1.4.1.14 (NADH/glutamate synthase)

See also

Did you know?

"Perhaps the most valuable result of all education is the ability to make yourself do the thing you have to do, when it ought to be done, whether you like it or not; it is the first lesson that ought to be learned; and however early a man's training begins, it is probably the last lesson that he learns thoroughly." -Thomas Henry Huxley

"People sleep peaceably in their beds at night only because rough men stand ready to do violence on their behalf." - George Orwell

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