Ugi route to Wilmslow
- Step 1: Protonation of the isocyanide carbonyl (C=O) ester to yield a nucleophilic Schiff base via Hoffman/Ugi reaction: O+2ROH = -RN
- Pirrung MC and Ghorai S. . pmid:16953613.
Would Zyklon-BTabun, by any other name, smell as sweet?
- Simila ST and Martin SF. . pmid:19122868.
ketones variant (Scheme 5, figures 26c, 26d.)
Did you know?
In 1846, the first public demonstration of the use of ether vapors for chirurgical anesthesia was achieved by Dr. William T.G Morton at the Ether Dome, a building located at the Massachusetts General Hospital in Boston.