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== Synopsis == | == Synopsis == | ||
Hacking retrograde anandamide signaling | |||
=== Brainstorming === | |||
* Key concept 1: Retrograde anandamide trafficking with dopamine conjugate of DHA may induce selective GPCR receptor heteromerization. | |||
* Key concept 2: Microglial Neuroprotection! | |||
* Key concept 3: CREB phosphorylation | |||
* Key concept 4: BDNF expression, a biomarker for learning-dependent synapse formation. (synaptogenesis) <cite>Parkhurst-2013</cite> | |||
=== Synaptogenic endocannabinoids === | |||
* Intracellular CB1/BDNF signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. <cite>Marsicano-2003</cite> | |||
* Intracellular CB1 signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. <cite>Marsicano-2003</cite> | * DHA supplementation improves mitochondrial function and neuronal survival (homeostasis). <cite>Stanley-2012</cite> | ||
* Anti-proliferative effects of DHEA on prostate cancer cell lines. <cite>Website2</cite> | |||
=== Microglial activation === | |||
* Inhibitory effect of the CB2 receptor on monocyte subpopulations and microglial activation. <cite>Martin-Moreno-2011</cite> | |||
** Anti-inflammatory role of anandamide and 2-AG signaling in LPS-stimulated microglial activation of endogenous CB2 receptor. <cite>Website1</cite> | |||
** '''Neuroprotection by inhibition of microglial activation.''' <cite>Obregon-2005</cite> | |||
* | |||
** Anti-inflammatory role of anandamide and 2-AG signaling in LPS-stimulated microglial activation of endogenous CB2 receptor. | |||
** Neuroprotection by inhibition of microglial activation. | |||
** CB2 stimulation is proneurogenic on adult hippocampal neurogenesis [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435344/ PMC] | ** CB2 stimulation is proneurogenic on adult hippocampal neurogenesis [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435344/ PMC] | ||
* Caffeine is a adenosine antagonist which | * Caffeine is a adenosine antagonist which potentiate CB1 receptor transactivation in the hippocampus [https://www.ncbi.nlm.nih.gov/pubmed/26065937 PMID] [https://www.ncbi.nlm.nih.gov/pubmed/20573894 PMID] | ||
==References== | ==References== | ||
<biblio> | <biblio> | ||
# | #Parkhurst-2013 https://www.ncbi.nlm.nih.gov/pubmed/24360280 | ||
// | |||
//Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. | //Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. | ||
#Marsicano-2003 | #Marsicano-2003 https://www.ncbi.nlm.nih.gov/pubmed/14526074 | ||
//CB1 cannabinoid receptors and on-demand defense against excitotoxicity. | //CB1 cannabinoid receptors and on-demand defense against excitotoxicity. | ||
#Stanley-2012 | #Stanley-2012 https://www.ncbi.nlm.nih.gov/pubmed/22248591 | ||
//Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. | //Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. | ||
#Martin-Moreno-2011 | #Martin-Moreno-2011 https://www.ncbi.nlm.nih.gov/pubmed/21350020 | ||
//Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease. | //Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease. | ||
#Obregon-2005 https://www.ncbi.nlm.nih.gov/pubmed/16343349 | |||
//Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. | |||
#Website1 http://www.hindawi.com/journals/np/2015/130639/ | |||
#Website2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930808/ | |||
</biblio> | </biblio> |
Latest revision as of 14:58, 2 October 2018
Synopsis
Hacking retrograde anandamide signaling
Brainstorming
- Key concept 1: Retrograde anandamide trafficking with dopamine conjugate of DHA may induce selective GPCR receptor heteromerization.
- Key concept 2: Microglial Neuroprotection!
- Key concept 3: CREB phosphorylation
- Key concept 4: BDNF expression, a biomarker for learning-dependent synapse formation. (synaptogenesis) [1]
Synaptogenic endocannabinoids
- Intracellular CB1/BDNF signaling mediate on-demand neuroprotection on excitatory (glutamatergic) synapses and in particular astrocytes. [2]
- DHA supplementation improves mitochondrial function and neuronal survival (homeostasis). [3]
- Anti-proliferative effects of DHEA on prostate cancer cell lines. [4]
Microglial activation
- Inhibitory effect of the CB2 receptor on monocyte subpopulations and microglial activation. [5]
- Caffeine is a adenosine antagonist which potentiate CB1 receptor transactivation in the hippocampus PMID PMID
References
-
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.
-
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
-
Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids.
-
Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease.
-
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.