User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions
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# The Wet Blanket: | # The Wet Blanket: | ||
## Role: Protect the hippocampus and neurons from [http://www.alzforum.org/news/research-news/endocannabinoids-wet-blanket-hippocampus-excitement glutamate excitoxicity]. | ## Role: Protect the hippocampus and neurons from [http://www.alzforum.org/news/research-news/endocannabinoids-wet-blanket-hippocampus-excitement glutamate excitoxicity]. | ||
## CB1: A '''synaptogenic''' receptor? (most likely) [http://www.ncbi.nlm.nih.gov/pubmed/16908411 | ## CB1: A '''synaptogenic''' receptor? (most likely) [http://www.ncbi.nlm.nih.gov/pubmed/16908411 5] [http://www.ncbi.nlm.nih.gov/pubmed/23570577 6] [http://www.ncbi.nlm.nih.gov/pubmed/21810478 7] | ||
# The Vector: | # The Vector: | ||
## FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule) | ## FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule) |
Revision as of 06:25, 23 October 2014
Introduction
Notes
Hypothesis
- DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
- DHA activate the NMDA receptor and upregulate the release of glutamate. 1
- Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. 2
- Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). (Pathway)
- Synaptic activation of neurotrophic GABA(B) receptor by endocannabinoids (CB1) promote synaptic function and learning. (Is activity-dependent synaptogenesis dependent on BDNF?) 3 4
Model
- The Promoter: omega 3 (fish oil supplement) fatty acids
- DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
- The Wet Blanket:
- Role: Protect the hippocampus and neurons from glutamate excitoxicity.
- CB1: A synaptogenic receptor? (most likely) 5 6 7
- The Vector:
- FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
- Activation of Ca2+ dependent BDNF via the TrkB pathway
Documentation
Protocol:
- http://www.ncbi.nlm.nih.gov/pubmed/23103355
- http://www.ncbi.nlm.nih.gov/pubmed/11470906
- http://www.ncbi.nlm.nih.gov/pubmed/9842734/
- http://www.ncbi.nlm.nih.gov/pubmed/15111006/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035504/
- http://www.ncbi.nlm.nih.gov/pubmed/22959887
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
- http://www.ncbi.nlm.nih.gov/pubmed/21288475
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661034/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773444/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687658/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160357/
- http://www.ncbi.nlm.nih.gov/pubmed/23426383
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574086/
Cannabinoids and hippocampal neurogenesis:
- http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/
DHA:
Anandamide signaling:
FAAH (fatty acid amide hydrolase):
Introduction to fatty amides:
Synaptic Plasticity:
Keywords
hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis
References
- Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, and Kim HY. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem. 2009 Oct;111(2):510-21. DOI:10.1111/j.1471-4159.2009.06335.x |
- Hagena H and Manahan-Vaughan D. Learning-facilitated synaptic plasticity at CA3 mossy fiber and commissural-associational synapses reveals different roles in information processing. Cereb Cortex. 2011 Nov;21(11):2442-9. DOI:10.1093/cercor/bhq271 |
- Adermark L, Talani G, and Lovinger DM. Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity. Eur J Neurosci. 2009 Jan;29(1):32-41. DOI:10.1111/j.1460-9568.2008.06551.x |
- Gaiarsa JL and Porcher C. Emerging neurotrophic role of GABAB receptors in neuronal circuit development. Front Cell Neurosci. 2013;7:206. DOI:10.3389/fncel.2013.00206 |