User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions

Revision as of 16:25, 17 October 2014

DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
1. DHA activate the NMDA receptor and upregulate the release of glutamate (?)
  1. Induction of LTP. (Pathway)
Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (synaptogenesis)

The Promoter: omega 3 (fish oil supplement) fatty acids
1. DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
The Wet Blanket:
1. Role: Protect the hippocampus and neurons from glutamate excitoxicity.
2. CB1: A synaptogenic receptor? (most likely) 1 2 3
The Vector:
1. FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)

Protocol:

Cannabinoids and hippocampal neurogenesis:

DHA:

Anandamide signaling:

FAAH (fatty acid amide hydrolase):

Introduction to fatty amides:

Synaptic Plasticity:

hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis

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 === Hypothesis ===
 # DHA may potentiate synaptic plasticity (and cognition) via [http://www.nature.com/mp/journal/v7/n3/full/4000999a.html retrograde CB1 signaling].
-## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA (glutamate) receptor] and upregulate the release of glutamate (?)
+## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA  receptor] and upregulate the release of glutamate (?)
 ### Induction of LTP. ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway])
 # Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (synaptogenesis)