User:Tkadm30/Notebook/Endocannabinoids
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Introduction
Notes
Hypothesis
- DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
- DHA activate the NMDA receptor and upregulate the release of glutamate. 1
- Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. 1
- Induction of LTP. (Pathway)
- Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (activity-dependent synaptogenesis)
Model
- The Promoter: omega 3 (fish oil supplement) fatty acids
- DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
- The Wet Blanket:
- Role: Protect the hippocampus and neurons from glutamate excitoxicity.
- CB1: A synaptogenic receptor? (most likely) 1 2 3
- The Vector:
- FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
Documentation
Protocol:
- http://www.ncbi.nlm.nih.gov/pubmed/23103355
- http://www.ncbi.nlm.nih.gov/pubmed/11470906
- http://www.ncbi.nlm.nih.gov/pubmed/9842734/
- http://www.ncbi.nlm.nih.gov/pubmed/15111006/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035504/
- http://www.ncbi.nlm.nih.gov/pubmed/22959887
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
- http://www.ncbi.nlm.nih.gov/pubmed/21288475
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661034/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773444/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687658/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160357/
Cannabinoids and hippocampal neurogenesis:
- http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/
DHA:
Anandamide signaling:
FAAH (fatty acid amide hydrolase):
Introduction to fatty amides:
Synaptic Plasticity:
Keywords
hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis