User:Tkadm30/Notebook/Endocannabinoids

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Introduction

Notes

Hypothesis

  1. DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
    1. DHA activate the NMDA receptor and upregulate the release of glutamate. 1
    2. Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. 1
      1. Induction of LTP. (Pathway)
  2. Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (activity-dependent synaptogenesis)

Model

  1. The Promoter: omega 3 (fish oil supplement) fatty acids
    1. DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
  2. The Wet Blanket:
    1. Role: Protect the hippocampus and neurons from glutamate excitoxicity.
    2. CB1: A synaptogenic receptor? (most likely) 1 2 3
  3. The Vector:
    1. FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)

Documentation

Protocol:

Cannabinoids and hippocampal neurogenesis:

DHA:

Anandamide signaling:

FAAH (fatty acid amide hydrolase):

Introduction to fatty amides:

Synaptic Plasticity:

Keywords

hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis

References

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