User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions
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=== Hypothesis === | === Hypothesis === | ||
# DHA may potentiate synaptic plasticity (and cognition) via [http://www.nature.com/mp/journal/v7/n3/full/4000999a.html retrograde CB1 signaling]. | # DHA may potentiate synaptic plasticity (and cognition) via [http://www.nature.com/mp/journal/v7/n3/full/4000999a.html retrograde CB1 signaling]. | ||
## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA receptor] and upregulate the release of glutamate. | ## DHA activate the (presynaptic?) [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA receptor] and upregulate the release of glutamate. <cite>ref1</cite> | ||
## | ### DHA-induced synapses (CA3) enhance synaptic plasticity, thus learning is enhanced. <cite>ref2</cite> | ||
### Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway]) | ### Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway]) | ||
# | ## Activation of inhibitory GABAergic synapse (GABA(B) receptor ?) by endocannabinoids (DHA) may promote synaptic function and learning. <cite>GABA-2013</cite> | ||
### TrkB receptor regulate activity-dependent synaptogenesis and BDNF expression <cite>TrkB-2009</cite> | |||
=== Model === | === Model === | ||
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# The Wet Blanket: | # The Wet Blanket: | ||
## Role: Protect the hippocampus and neurons from [http://www.alzforum.org/news/research-news/endocannabinoids-wet-blanket-hippocampus-excitement glutamate excitoxicity]. | ## Role: Protect the hippocampus and neurons from [http://www.alzforum.org/news/research-news/endocannabinoids-wet-blanket-hippocampus-excitement glutamate excitoxicity]. | ||
## CB1: A '''synaptogenic''' receptor? (most likely) | ## CB1: A '''synaptogenic''' receptor? (most likely) | ||
# The | # The Milestone: | ||
## FAAH | ## FAAH hydrolysis of DHEA (a endocannabinoid like molecule) | ||
## | ## [http://www.kegg.jp/dbget-bin/www_bget?ko:K04360 TrkB] (2.7.10.1) potentiate GABAergic synaptic activation: | ||
### BDNF expression is Ca2+ and CREB dependent | |||
=== Documentation === | === Documentation === | ||
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* http://www.ncbi.nlm.nih.gov/pubmed/23426383 | * http://www.ncbi.nlm.nih.gov/pubmed/23426383 | ||
* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574086/ | * http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574086/ | ||
* http://www.ncbi.nlm.nih.gov/pubmed/17525344 | |||
Cannabinoids and hippocampal neurogenesis: | Cannabinoids and hippocampal neurogenesis: | ||
* http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/ | * http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/ | ||
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=== Keywords === | === Keywords === | ||
hippocampus, anandamide, FAAH, DHA, THC, neurogenesis, synaptogenesis, GABA, synaptamide | hippocampus, anandamide, FAAH, DHA, THC, neurogenesis, synaptogenesis, GABA, synaptamide, BDNF, LTP | ||
== References == | == References == | ||
Line 58: | Line 61: | ||
#ref1 pmid=19682204 | #ref1 pmid=19682204 | ||
#ref2 pmid=21493717 | #ref2 pmid=21493717 | ||
# | #GABA-2013 pmid=24282395 | ||
#ref4 pmid= | #ref4 pmid=21810478 | ||
#ref5 pmid= | #ref5 pmid=21414899 | ||
#TrkB-2009 pmid=19188247 | |||
</biblio> | </biblio> |
Revision as of 15:09, 25 October 2014
Introduction
Notes
Hypothesis
- DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
- DHA activate the (presynaptic?) NMDA receptor and upregulate the release of glutamate. [1]
- Activation of inhibitory GABAergic synapse (GABA(B) receptor ?) by endocannabinoids (DHA) may promote synaptic function and learning. [3]
- TrkB receptor regulate activity-dependent synaptogenesis and BDNF expression [4]
Model
- The Promoter: omega 3 (fish oil supplement) fatty acids
- DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
- The Wet Blanket:
- Role: Protect the hippocampus and neurons from glutamate excitoxicity.
- CB1: A synaptogenic receptor? (most likely)
- The Milestone:
- FAAH hydrolysis of DHEA (a endocannabinoid like molecule)
- TrkB (2.7.10.1) potentiate GABAergic synaptic activation:
- BDNF expression is Ca2+ and CREB dependent
Documentation
Protocol:
- http://www.ncbi.nlm.nih.gov/pubmed/23103355
- http://www.ncbi.nlm.nih.gov/pubmed/11470906
- http://www.ncbi.nlm.nih.gov/pubmed/9842734/
- http://www.ncbi.nlm.nih.gov/pubmed/15111006/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035504/
- http://www.ncbi.nlm.nih.gov/pubmed/22959887
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
- http://www.ncbi.nlm.nih.gov/pubmed/21288475
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661034/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773444/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687658/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160357/
- http://www.ncbi.nlm.nih.gov/pubmed/23426383
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574086/
- http://www.ncbi.nlm.nih.gov/pubmed/17525344
Cannabinoids and hippocampal neurogenesis:
- http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/
DHA:
Anandamide signaling:
FAAH (fatty acid amide hydrolase):
Introduction to fatty amides:
Synaptic Plasticity:
Keywords
hippocampus, anandamide, FAAH, DHA, THC, neurogenesis, synaptogenesis, GABA, synaptamide, BDNF, LTP
References
- Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, and Kim HY. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem. 2009 Oct;111(2):510-21. DOI:10.1111/j.1471-4159.2009.06335.x |
- Hagena H and Manahan-Vaughan D. Learning-facilitated synaptic plasticity at CA3 mossy fiber and commissural-associational synapses reveals different roles in information processing. Cereb Cortex. 2011 Nov;21(11):2442-9. DOI:10.1093/cercor/bhq271 |
- Gaiarsa JL and Porcher C. Emerging neurotrophic role of GABAB receptors in neuronal circuit development. Front Cell Neurosci. 2013;7:206. DOI:10.3389/fncel.2013.00206 |
- Huang ZJ. Activity-dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond. J Physiol. 2009 May 1;587(Pt 9):1881-8. DOI:10.1113/jphysiol.2008.168211 |
- Kim HY, Spector AA, and Xiong ZM. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):114-20. DOI:10.1016/j.prostaglandins.2011.07.002 |
- Chen AI, Nguyen CN, Copenhagen DR, Badurek S, Minichiello L, Ranscht B, and Reichardt LF. TrkB (tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex. J Neurosci. 2011 Feb 23;31(8):2769-80. DOI:10.1523/JNEUROSCI.4991-10.2011 |