User:Tkadm30/Notebook/Endocannabinoids: Difference between revisions

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# DHA may potentiate synaptic plasticity (and cognition) via [http://www.nature.com/mp/journal/v7/n3/full/4000999a.html retrograde CB1 signaling].
# DHA may potentiate synaptic plasticity (and cognition) via [http://www.nature.com/mp/journal/v7/n3/full/4000999a.html retrograde CB1 signaling].
## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA  receptor] and upregulate the release of glutamate. [http://www.ncbi.nlm.nih.gov/pubmed/19682204 1]  
## DHA activate the [http://www.genome.jp/dbget-bin/www_bget?hsa:2902+hsa:2903+hsa:2904+hsa:2905+hsa:2906 NMDA  receptor] and upregulate the release of glutamate. [http://www.ncbi.nlm.nih.gov/pubmed/19682204 1]  
## Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. [http://cercor.oxfordjournals.org/content/21/11/2442.full 1]
## Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. [http://cercor.oxfordjournals.org/content/21/11/2442.full 2]
### Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway])
### Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). ([http://www.genome.jp/kegg-bin/show_pathway?hsa04720+2902 Pathway])
# Synaptic activation of GABA(B) receptor by endocannabinoids promotes synaptic function and learning. (activity-dependent synaptogenesis)
# Synaptic activation of neurotrophic GABA(B) receptor by endocannabinoids (CB1) promote synaptic function and learning. (Is activity-dependent synaptogenesis dependent on BDNF?) [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661034/ 3] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824957/ 4]


=== Model ===
=== Model ===
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# The Wet Blanket:  
# The Wet Blanket:  
## Role: Protect the hippocampus and neurons from [http://www.alzforum.org/news/research-news/endocannabinoids-wet-blanket-hippocampus-excitement glutamate excitoxicity].   
## Role: Protect the hippocampus and neurons from [http://www.alzforum.org/news/research-news/endocannabinoids-wet-blanket-hippocampus-excitement glutamate excitoxicity].   
## CB1: A '''synaptogenic''' receptor? (most likely) [http://www.ncbi.nlm.nih.gov/pubmed/16908411 1] [http://www.ncbi.nlm.nih.gov/pubmed/23570577 2] [http://www.ncbi.nlm.nih.gov/pubmed/21810478 3]
## CB1: A '''synaptogenic''' receptor? (most likely) [http://www.ncbi.nlm.nih.gov/pubmed/21810478 5]
# The Vector:
# The Vector:
## FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
## FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
## Activation of Ca2+ dependent BDNF via the [http://www.kegg.jp/dbget-bin/www_bget?ko:K04360 TrkB] pathway


=== Documentation ===
=== Documentation ===
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* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160357/
* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160357/
* http://www.ncbi.nlm.nih.gov/pubmed/23426383
* http://www.ncbi.nlm.nih.gov/pubmed/23426383
* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574086/
Cannabinoids and hippocampal neurogenesis:  
Cannabinoids and hippocampal neurogenesis:  
* http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/
* http://www.truthonpot.com/2013/07/13/scientists-discover-another-way-marijuana-helps-the-brain-grow/
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=== Keywords ===
=== Keywords ===
hippocampus, anandamide, FAAH, fatty acids, THC, neurogenesis, synaptogenesis
hippocampus, anandamide, FAAH, DHA, THC, neurogenesis, synaptogenesis, GABA, synaptamide


== References ==
== References ==
<biblio>
#ref1 pmid=19682204
#ref2 pmid=21493717
#ref3 pmid=19120438
#ref4 pmid=24282395
#ref5 pmid=21810478
</biblio>

Revision as of 06:29, 23 October 2014

Introduction

Notes

Hypothesis

  1. DHA may potentiate synaptic plasticity (and cognition) via retrograde CB1 signaling.
    1. DHA activate the NMDA receptor and upregulate the release of glutamate. 1
    2. Hippocampal CA3 synapses facilitate synaptic plasticity, thus learning is enhanced. 2
      1. Induction of Long-Term Potentiation/Persistent synaptic plasticity (LTP). (Pathway)
  2. Synaptic activation of neurotrophic GABA(B) receptor by endocannabinoids (CB1) promote synaptic function and learning. (Is activity-dependent synaptogenesis dependent on BDNF?) 3 4

Model

  1. The Promoter: omega 3 (fish oil supplement) fatty acids
    1. DHA (docosahexaenoic acid) conjugate (in the hippocampus?) is docosahexaenoyl ethanolamide (DHEA).
  2. The Wet Blanket:
    1. Role: Protect the hippocampus and neurons from glutamate excitoxicity.
    2. CB1: A synaptogenic receptor? (most likely) 5
  3. The Vector:
    1. FAAH/anandamide hydrolysis of DHEA (a endocannabinoid like molecule)
    2. Activation of Ca2+ dependent BDNF via the TrkB pathway

Documentation

Protocol:

Cannabinoids and hippocampal neurogenesis:

DHA:

Anandamide signaling:

FAAH (fatty acid amide hydrolase):

Introduction to fatty amides:

Synaptic Plasticity:

Keywords

hippocampus, anandamide, FAAH, DHA, THC, neurogenesis, synaptogenesis, GABA, synaptamide

References

  1. Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, and Kim HY. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem. 2009 Oct;111(2):510-21. DOI:10.1111/j.1471-4159.2009.06335.x | PubMed ID:19682204 | HubMed [ref1]
  2. Hagena H and Manahan-Vaughan D. Learning-facilitated synaptic plasticity at CA3 mossy fiber and commissural-associational synapses reveals different roles in information processing. Cereb Cortex. 2011 Nov;21(11):2442-9. DOI:10.1093/cercor/bhq271 | PubMed ID:21493717 | HubMed [ref2]
  3. Adermark L, Talani G, and Lovinger DM. Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity. Eur J Neurosci. 2009 Jan;29(1):32-41. DOI:10.1111/j.1460-9568.2008.06551.x | PubMed ID:19120438 | HubMed [ref3]
  4. Gaiarsa JL and Porcher C. Emerging neurotrophic role of GABAB receptors in neuronal circuit development. Front Cell Neurosci. 2013;7:206. DOI:10.3389/fncel.2013.00206 | PubMed ID:24282395 | HubMed [ref4]
  5. Kim HY, Spector AA, and Xiong ZM. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):114-20. DOI:10.1016/j.prostaglandins.2011.07.002 | PubMed ID:21810478 | HubMed [ref5]

All Medline abstracts: PubMed | HubMed

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