User:Tkadm30/Notebook/EGFR

Useful links on EGF(R)-mediated drug delivery

• http://nrresource.org/Pathways/VDR%20Targets/92391.html

Case studies

• Breast cancer epithelial stem cells switching and the risks of EGF(R)-targeted phosphorylation:
  • Epithelial Stem Cells: Turning over New Leaves (Rockefeller University)
• Receptor-associated tyrosine kinase signaling (SH1/SH2 ?) for targeted drug delivery to epithelial stem cells membranes?

TODO

• Is programmed cell-death from cell-specific DNA based gene regulation via p53 gene/protein is leading to cell apoptosis? If so, could DNA programmed apoptosis result from aggregated nanoparticles to epithelial/endothelial stem cells membranes (ie: immunoglobin-like domain receptor) ?
• Glycoproteins role in programmed cell division acting as a master toll-like switch for receptor-associated drug delivery? (ie: EGFR)
• On lipid rafts: "Plasma membranes are heterogeneous and contain microdomains for lipid composition and receptors, especially in T and B lymphocytes and mast cells. Rafts are a way of concentrating receptors, the lipids and lipid tethered proteins together to provide the elements needed to activate secondary signals." (http://bioweb.wku.edu/courses/biol566/L19SignalPathnonRPTK.html)

Keywords

Src homology domains, SH1, SH2, PH (Pleckstrin Homology domain), cyclosporamide (a alkylating agent used in cancer therapy)

References

1. C. Branden, J. Tooze, "Introduction to protein structure", [270-279]